Literature DB >> 25339773

Virulence determinants in the PB2 gene of a mouse-adapted H9N2 virus.

Qingtao Liu1, Junqing Huang1, Yuxin Chen1, Hongzhi Chen1, Qunhui Li1, Liang He1, Xiaoli Hao1, Jingjing Liu1, Min Gu1, Jiao Hu1, Xiaoquan Wang1, Shunlin Hu1, Xiaowen Liu1, Xiufan Liu2.   

Abstract

The molecular bases of adaptation and pathogenicity of H9N2 influenza virus in mammals are largely unknown. Here, we show that a mouse-adapted PB2 gene with a phenylalanine-to-leucine mutation (F404L) mainly contributes to enhanced polymerase activity, replication, and pathogenicity of H9N2 in mice and also increases the virulence of the H5N1 and 2009 pandemic H1N1 influenza viruses. Therefore, we defined a novel pathogenic determinant, providing further insights into the pathogenesis of influenza viruses in mammals.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25339773      PMCID： PMC4301167          DOI： 10.1128/JVI.01775-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

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Journal:  Cell Host Microbe       Date:  2013-09-19       Impact factor: 21.023

2.  Genetic diversity of H9N2 influenza viruses from pigs in China: a potential threat to human health?

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Journal:  Vet Microbiol       Date:  2010-11-09       Impact factor: 3.293

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4.  Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic.

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Journal:  Nature       Date:  2009-06-25       Impact factor: 49.962

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Journal:  PLoS One       Date:  2010-09-29       Impact factor: 3.240

6.  Avian influenza A (H9N2): computational molecular analysis and phylogenetic characterization of viral surface proteins isolated between 1997 and 2009 from the human population.

Authors:  Azeem M Butt; Samerene Siddique; Muhammad Idrees; Yigang Tong
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7.  Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013.

Authors:  T Kageyama; S Fujisaki; E Takashita; H Xu; S Yamada; Y Uchida; G Neumann; T Saito; Y Kawaoka; M Tashiro
Journal:  Euro Surveill       Date:  2013-04-11

8.  Differences in transmissibility and pathogenicity of reassortants between H9N2 and 2009 pandemic H1N1 influenza A viruses from humans and swine.

Authors:  Liang He; Qiwen Wu; Kaijun Jiang; Zhiqiang Duan; Jingjing Liu; Haixu Xu; Zhu Cui; Min Gu; Xiaoquan Wang; Xiaowen Liu; Xiufan Liu
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Journal:  J Virol       Date:  2009-06-24       Impact factor: 5.103

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Authors:  Yanfang Li; Sujuan Chen; Xiaojian Zhang; Qiang Fu; Zhiye Zhang; Shaohua Shi; Yinbiao Zhu; Min Gu; Daxin Peng; Xiufan Liu
Journal:  PLoS One       Date:  2014-04-17       Impact factor: 3.240
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  11 in total

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Journal:  Cold Spring Harb Perspect Med       Date:  2020-06-01       Impact factor: 6.915

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Journal:  J Virol       Date:  2015-12-09       Impact factor: 5.103

4.  Two Genetically Similar H9N2 Influenza A Viruses Show Different Pathogenicity in Mice.

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Journal:  Clin Exp Vaccine Res       Date:  2017-07-26

6.  The molecular evolutionary characteristics of new isolated H9N2 AIV from East China and the function of vimentin on virus replication in MDCK cells.

Authors:  Yuan Nan Yu; Yang Zheng; Shan Shan Hao; Ze Zhang; Jia Xi Cai; Man Man Zong; Xiu Li Feng; Qing Tao Liu
Journal:  Virol J       Date:  2020-06-17       Impact factor: 4.099

7.  Adaptive amino acid substitutions enable transmission of an H9N2 avian influenza virus in guinea pigs.

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Journal:  Sci Rep       Date:  2019-12-24       Impact factor: 4.379

8.  Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China.

Authors:  Libin Liang; Guohua Deng; Jianzhong Shi; Shuai Wang; Qianyi Zhang; Huihui Kong; Chunyang Gu; Yuntao Guan; Yasuo Suzuki; Yanbing Li; Yongping Jiang; Guobin Tian; Liling Liu; Chengjun Li; Hualan Chen
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9.  Mouse adaptation of influenza B virus increases replication in the upper respiratory tract and results in droplet transmissibility in ferrets.

Authors:  Eun-Ha Kim; Su-Jin Park; Hyeok-Il Kwon; Se Mi Kim; Young-il Kim; Min-Suk Song; Eun-Ji Choi; Philippe Noriel Q Pascua; Young-Ki Choi
Journal:  Sci Rep       Date:  2015-11-03       Impact factor: 4.379

10.  Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.

Authors:  Chung-Young Lee; Se-Hee An; Ilhwan Kim; Du-Min Go; Dae-Yong Kim; Jun-Gu Choi; Youn-Jeong Lee; Jae-Hong Kim; Hyuk-Joon Kwon
Journal:  Sci Rep       Date:  2017-08-31       Impact factor: 4.379
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