Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway.

Literature DB >> 25339611

Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway.

Scott T Baker¹, Shane M Turgeon², Erik D Tulgren³, Jeanne Wigant³, Omeed Rahimi³, Karla J Opperman², Brock Grill⁴.

Abstract

We show that loss-of-function mutations in kinases of the MLK-1 pathway (mlk-1, mek-1, and kgb-1/jnk) function cell-autonomously in neurons to suppress defects in synapse formation and axon termination caused by rpm-1 loss of function. Our genetic analysis also suggests that the phosphatase PPM-1, like RPM-1, is a potential inhibitor of kinases in the MLK-1 pathway.

Entities: Gene Species

Keywords: JNK; MAP kinase; RPM-1; axon; synapse

Mesh：

Substances：

Year: 2014 PMID： 25339611 PMCID： PMC4286679 DOI： 10.1534/genetics.114.170589

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

15 in total

1. rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.

Authors: A M Schaefer; G D Hadwiger; M L Nonet
Journal: Neuron Date: 2000-05 Impact factor: 17.173

2. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.

Authors: Paola Nix; Naoki Hisamoto; Kunihiro Matsumoto; Michael Bastiani
Journal: Proc Natl Acad Sci U S A Date: 2011-06-13 Impact factor: 11.205

3. Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling.

Authors: Susan Klinedinst; Xin Wang; Xin Xiong; Jill M Haenfler; Catherine A Collins
Journal: J Neurosci Date: 2013-07-31 Impact factor: 6.167

4. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.

Authors: Katsunori Nakata; Benjamin Abrams; Brock Grill; Alexandr Goncharov; Xun Huang; Andrew D Chisholm; Yishi Jin
Journal: Cell Date: 2005-02-11 Impact factor: 41.582

5. RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.

Authors: Brock Grill; Lizhen Chen; Erik D Tulgren; Scott T Baker; Willy Bienvenut; Matthew Anderson; Manfredo Quadroni; Yishi Jin; Craig C Garner
Journal: J Neurosci Date: 2012-02-22 Impact factor: 6.167

6. An SCF-like ubiquitin ligase complex that controls presynaptic differentiation.

Authors: Edward H Liao; Wesley Hung; Benjamin Abrams; Mei Zhen
Journal: Nature Date: 2004-06-20 Impact factor: 49.962

7. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.

Authors: Dong Yan; Zilu Wu; Andrew D Chisholm; Yishi Jin
Journal: Cell Date: 2009-09-04 Impact factor: 41.582

8. JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.

Authors: Sarah Huntwork-Rodriguez; Bei Wang; Trent Watkins; Arundhati Sengupta Ghosh; Christine D Pozniak; Daisy Bustos; Kim Newton; Donald S Kirkpatrick; Joseph W Lewcock
Journal: J Cell Biol Date: 2013-08-26 Impact factor: 10.539

9. RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.

Authors: Scott T Baker; Karla J Opperman; Erik D Tulgren; Shane M Turgeon; Willy Bienvenut; Brock Grill
Journal: PLoS Genet Date: 2014-05-08 Impact factor: 5.917

10. The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin.

Authors: Erik D Tulgren; Shane M Turgeon; Karla J Opperman; Brock Grill
Journal: PLoS Genet Date: 2014-07-10 Impact factor: 5.917

8 in total

1. Defining Minimal Binding Regions in Regulator of Presynaptic Morphology 1 (RPM-1) Using Caenorhabditis elegans Neurons Reveals Differential Signaling Complexes.

Authors: Scott T Baker; Brock Grill
Journal: J Biol Chem Date: 2016-12-15 Impact factor: 5.157

Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway.

1. rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.

2. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.

3. Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling.

4. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.

5. RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.

6. An SCF-like ubiquitin ligase complex that controls presynaptic differentiation.

7. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.

8. JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.

9. RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.

10. The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin.

1. Defining Minimal Binding Regions in Regulator of Presynaptic Morphology 1 (RPM-1) Using Caenorhabditis elegans Neurons Reveals Differential Signaling Complexes.

2. RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability.

Review 3. Timing of neuronal plasticity in development and aging.

Review 4. Historical perspective and progress on protein ubiquitination at glutamatergic synapses.

5. Developmental Function of the PHR Protein RPM-1 Is Required for Learning in Caenorhabditis elegans.

6. A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning.

7. Ubiquitin ligase activity inhibits Cdk5 to control axon termination.

Review 8. The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration.