Literature DB >> 25338004

Convenient detection of metal-DNA, metal-RNA, and metal-protein adducts with a click-modified Pt(II) complex.

Alan D Moghaddam1, Jonathan D White, Rachael M Cunningham, Andrea N Loes, Michael M Haley, Victoria J DeRose.   

Abstract

cis-[Pt(2-azido-1,3-propanediamine)Cl2] is a reagent for high-yield post-treatment fluorescent labelling of Pt(II) biomolecular targets using click chemistry and exhibits a bias in conformational isomers in the context of duplex DNA. Pt-protein adducts are detected using BSA as a model. Following in vivo treatment, long-lived Pt-RNA adducts are detected on ribosomal RNA.

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Year:  2015        PMID： 25338004     DOI： 10.1039/c4dt02649g

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  5 in total

Review 1.  Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.

Authors:  Jessica L Childs-Disney; Matthew D Disney
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-10-22       Impact factor: 13.820

2.  Spectroscopy, Structure, Biomacromolecular Interactions, and Antiproliferation Activity of a Fe(II) Complex With DPA-Bpy as Pentadentate Ligand.

Authors:  Hehe Bai; Jia Shi; Qingyu Guo; Wenming Wang; Zhigang Zhang; Yafeng Li; Manohar Vennampalli; Xuan Zhao; Hongfei Wang
Journal:  Front Chem       Date:  2022-04-25       Impact factor: 5.545

Review 3.  Post-transcriptional diversity in riboproteins and RNAs in aging and cancer.

Authors:  Jurandir Cruz; Bernardo Lemos
Journal:  Semin Cancer Biol       Date:  2021-08-30       Impact factor: 15.707

4.  A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II)-Modified Triplex-Forming Oligonucleotides.

Authors:  Joseph Hennessy; Bríonna McGorman; Zara Molphy; Nicholas P Farrell; Daniel Singleton; Tom Brown; Andrew Kellett
Journal:  Angew Chem Int Ed Engl       Date:  2021-12-03       Impact factor: 16.823

Review 5.  Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes.

Authors:  Nicola J Farrer; Darren M Griffith
Journal:  Curr Opin Chem Biol       Date:  2020-01-13       Impact factor: 8.822
  5 in total

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