OBJECTIVE: The prevalence of breast cancer susceptibility gene 1 mutation in breast cancer patients of south China has not been well revealed. This study was to invest the prevalence of BRCA1 gene mutation in breast cancer patients in Guangxi, China, and to try reflecting its relevance in genetic counseling of breast cancer. METHODS: In this study, 463 breast cancer patients and 30 healthy women (control group) were involved. Entire sequence and splicing sites of BRCA1 genes were detected by PCR-DNA sequencing. RESULTS: About 8.9% (41/463) patients were with 22 BRCA1 mutations (all in exon 10). The average hospitalized age of BRCA1-associated breast cancer cases was significantly younger (t = -2.965, P = 0.003). The nuclear grade (U = 2321.0, P = 0.030), ER (U = 4343.5, P = 0.041) and CerbB-2 (U = 3894.0, P = 0.038) expression levels, and triple negative breast cancer diagnosing rate (χ(2) = 4.719, P = 0.03) were disclosed more in BRCA1-associated patients. CONCLUSIONS: The four most frequent BRCA1 mutation (2798 T > C, 3971 G > A, 3971 G > A and 624 C > T) found in female breast cancer cases in Guangxi are all located in exon 10. BRCA1-associated breast cancer cases have earlier onset age, higher nuclear grade and negative ER and CerbB-2 expression.
OBJECTIVE: The prevalence of breast cancer susceptibility gene 1 mutation in breast cancerpatients of south China has not been well revealed. This study was to invest the prevalence of BRCA1 gene mutation in breast cancerpatients in Guangxi, China, and to try reflecting its relevance in genetic counseling of breast cancer. METHODS: In this study, 463 breast cancerpatients and 30 healthy women (control group) were involved. Entire sequence and splicing sites of BRCA1 genes were detected by PCR-DNA sequencing. RESULTS: About 8.9% (41/463) patients were with 22 BRCA1 mutations (all in exon 10). The average hospitalized age of BRCA1-associated breast cancer cases was significantly younger (t = -2.965, P = 0.003). The nuclear grade (U = 2321.0, P = 0.030), ER (U = 4343.5, P = 0.041) and CerbB-2 (U = 3894.0, P = 0.038) expression levels, and triple negative breast cancer diagnosing rate (χ(2) = 4.719, P = 0.03) were disclosed more in BRCA1-associated patients. CONCLUSIONS: The four most frequent BRCA1 mutation (2798 T > C, 3971 G > A, 3971 G > A and 624 C > T) found in female breast cancer cases in Guangxi are all located in exon 10. BRCA1-associated breast cancer cases have earlier onset age, higher nuclear grade and negative ER and CerbB-2 expression.
Entities:
Keywords:
BRCA1 gene mutation; Breast cancer; histopathology; pathology
Authors: Liyu Jiang; Tingting Ma; Meena S Moran; Xiaoli Kong; Xiaoyan Li; Bruce G Haffty; Qifeng Yang Journal: Anticancer Res Date: 2011-06 Impact factor: 2.480
Authors: Deann P Atchley; Constance T Albarracin; Adriana Lopez; Vicente Valero; Christopher I Amos; Ana Maria Gonzalez-Angulo; Gabriel N Hortobagyi; Banu K Arun Journal: J Clin Oncol Date: 2008-09-10 Impact factor: 44.544
Authors: Michael J Hall; Julia E Reid; Lynn A Burbidge; Dmitry Pruss; Amie M Deffenbaugh; Cynthia Frye; Richard J Wenstrup; Brian E Ward; Thomas A Scholl; Walter W Noll Journal: Cancer Date: 2009-05-15 Impact factor: 6.860
Authors: Klaudia Holeckova; Katarina Baluchova; Mark Hives; Ludovit Musak; Jan Kliment; Maria Skerenova Journal: In Vivo Date: 2020 Jul-Aug Impact factor: 2.155