M S Rifouna1, A D Reus2, A H J Koning3, P J van der Spek3, N Exalto1, E A P Steegers1, J S E Laven4. 1. Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, 3000 CA, The Netherlands. 2. Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, 3000 CA, The Netherlands a.reus@erasmusmc.nl. 3. Department of Bioinformatics, Erasmus MC, University Medical Center, Room Na-1523, PO Box 2040, Rotterdam, 3000 CA, The Netherlands. 4. Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Erasmus MC, University Medical Center, Rotterdam, 3000 CA, The Netherlands.
Abstract
STUDY QUESTION: Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies? SUMMARY ANSWER: Any possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies is not detected by a difference in PBVV or TV at an early gestational age (GA). WHAT IS KNOWN ALREADY: Assisted reproductive technology pregnancies have been associated with an increased risk of placenta-related adverse pregnancy outcomes. It is unclear whether these effects originate from infertility or from the technique itself. STUDY DESIGN, SIZE, DURATION: We performed a retrospective cohort study in which 154 pregnant patients qualified for participation. PARTICIPANTS/MATERIALS, SETTING, METHODS: Out of 154 pregnant patients, 84 conceived spontaneously and 70 conceived after IVF or IVF/ICSI. We determined the TV at 10 weeks GA by Virtual Organ Computer-aided AnaLysis measuring application and the PBVV at 12 weeks GA by the virtual reality operating system of BARCO I-Space in both subgroups. The investigators were blinded to the mode of conception during the measurements. Analysis was limited to singleton pregnancies with only one sac ever detectable. MAIN RESULTS AND THE ROLE OF CHANCE: There were no differences in TV (mean 42.7, SD 15.9 versus mean 41.2, SD 13.9, P = 0.70) and PBVV (mean 27.6, SD 16.9 versus mean 24.8, SD 19.9, P = 0.20) between IVF or IVF/ICSI pregnancies and spontaneously conceived pregnancies. There was a significant correlation between TV and PBVV (rs = 0.283, P = 0.004). LIMITATIONS, REASONS FOR CAUTION: The limitations of the present study concern the small size of the study groups. WIDER IMPLICATIONS OF THE FINDINGS: IVF or IVF/ICSI does not seem to be associated with abnormal placentation. STUDY FUNDING/COMPETING INTERESTS: This study was financially supported by the Erasmus Trustfonds, the Meindert de Hoop foundation and the Fonds NutsOhra. No competing interests are declared.
STUDY QUESTION: Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies? SUMMARY ANSWER: Any possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies is not detected by a difference in PBVV or TV at an early gestational age (GA). WHAT IS KNOWN ALREADY: Assisted reproductive technology pregnancies have been associated with an increased risk of placenta-related adverse pregnancy outcomes. It is unclear whether these effects originate from infertility or from the technique itself. STUDY DESIGN, SIZE, DURATION: We performed a retrospective cohort study in which 154 pregnant patients qualified for participation. PARTICIPANTS/MATERIALS, SETTING, METHODS: Out of 154 pregnant patients, 84 conceived spontaneously and 70 conceived after IVF or IVF/ICSI. We determined the TV at 10 weeks GA by Virtual Organ Computer-aided AnaLysis measuring application and the PBVV at 12 weeks GA by the virtual reality operating system of BARCO I-Space in both subgroups. The investigators were blinded to the mode of conception during the measurements. Analysis was limited to singleton pregnancies with only one sac ever detectable. MAIN RESULTS AND THE ROLE OF CHANCE: There were no differences in TV (mean 42.7, SD 15.9 versus mean 41.2, SD 13.9, P = 0.70) and PBVV (mean 27.6, SD 16.9 versus mean 24.8, SD 19.9, P = 0.20) between IVF or IVF/ICSI pregnancies and spontaneously conceived pregnancies. There was a significant correlation between TV and PBVV (rs = 0.283, P = 0.004). LIMITATIONS, REASONS FOR CAUTION: The limitations of the present study concern the small size of the study groups. WIDER IMPLICATIONS OF THE FINDINGS:IVF or IVF/ICSI does not seem to be associated with abnormal placentation. STUDY FUNDING/COMPETING INTERESTS: This study was financially supported by the Erasmus Trustfonds, the Meindert de Hoop foundation and the Fonds NutsOhra. No competing interests are declared.
Authors: Sara J Churchill; Erica T Wang; Marcy Akhlaghpour; Ellen H Goldstein; Dina Eschevarria; Naomi Greene; Matthew Macer; Temeka Zore; John Williams; Margareta D Pisarska Journal: Fertil Steril Date: 2017-05-10 Impact factor: 7.329
Authors: Tessa Drijkoningen; Robert Knoter; Emile G Coerkamp; Anton H J Koning; Steven J Rhemrev; Frank J Beeres Journal: Arch Bone Jt Surg Date: 2016-10
Authors: A H Jan Danser; Régine P M Steegers-Theunissen; Rosalieke E Wiegel; Maud J H Karsten; Igna F Reijnders; Lenie van Rossem; Sten P Willemsen; Annemarie G M G J Mulders; Anton H J Koning; Eric A P Steegers Journal: Reprod Biol Endocrinol Date: 2021-11-04 Impact factor: 5.211
Authors: Linette van Duijn; Melek Rousian; Igna F Reijnders; Sten P Willemsen; Esther B Baart; Joop S E Laven; Régine P M Steegers-Theunissen Journal: Hum Reprod Date: 2021-07-19 Impact factor: 6.918
Authors: Melek Rousian; Sam Schoenmakers; Alex J Eggink; Dionne V Gootjes; Anton H J Koning; Maria P H Koster; Annemarie G M G J Mulders; Esther B Baart; Irwin K M Reiss; Joop S E Laven; Eric A P Steegers; Régine P M Steegers-Theunissen Journal: Int J Epidemiol Date: 2021-11-10 Impact factor: 7.196