Kevin Phan1, Ashleigh Xie2, Yi-Chin Tsai3, Narendra Kumar4, Mark La Meir5, Tristan D Yan6. 1. The Collaborative Research (CORE) Group, Macquarie University Hospital, Macquarie University, 2 Technology Place, Sydney, Australia Sydney Medical School, The University of Sydney, Sydney, Australia. 2. The Collaborative Research (CORE) Group, Macquarie University Hospital, Macquarie University, 2 Technology Place, Sydney, Australia. 3. The Prince Charles Hospital, Chermside, Australia. 4. Department of Cardiothoracic Surgery and Cardiology, Academic Hospital Maastricht and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands. 5. Department of Cardiothoracic Surgery and Cardiology, Academic Hospital Maastricht and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands University Hospital Brussels, Brussels, Belgium. 6. The Collaborative Research (CORE) Group, Macquarie University Hospital, Macquarie University, 2 Technology Place, Sydney, Australia Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia tristanyan@annalscts.com.
Abstract
AIMS: Surgical ablation performed concomitantly with cardiac surgery has emerged as an effective curative strategy for atrial fibrillation (AF). Left atrial (LA) lesion sets for ablation have been suggested to reduce procedural times and post-surgical bradycardia compared with biatrial (BA) lesions. Given the inconclusive literature regarding BA vs. LA ablation, the present meta-analysis sought to assess the current evidence. METHODS AND RESULTS: Electronic searches were performed using six databases from their inception to December 2013, identifying all relevant randomized trials and observational studies comparing BA vs. LA surgical ablation AF patients undertaking cardiac surgery. In 10 included studies, 2225 patient results were available for analysis to compare BA (n = 888) vs. LA (n = 1337) ablation. Sinus rhythm prevalence was higher in the BA cohort compared with the LA cohort at 6-month and 12-month follow-up, but similar beyond 1 year. Permanent pacemaker implantations were higher in the BA cohort, but 30-day and late mortality, neurological events, and reoperation for bleeding were similar between BA and LA groups. CONCLUSIONS: Biatrial and LA ablations produced comparable 30-day and late mortality but LA was associated with significantly reduced permanent pacemaker implantation rates. Biatrial ablation appeared to be more efficacious than LA ablation in achieving SR at 1 year, but this difference was not maintained beyond 1 year. Trends appear to be driven by the preferential selection of long-standing and persistent AF patients for the BA approach. Future randomized studies of adequate follow-up are required to validate risks and benefits of BA vs. LA surgical ablation. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: Surgical ablation performed concomitantly with cardiac surgery has emerged as an effective curative strategy for atrial fibrillation (AF). Left atrial (LA) lesion sets for ablation have been suggested to reduce procedural times and post-surgical bradycardia compared with biatrial (BA) lesions. Given the inconclusive literature regarding BA vs. LA ablation, the present meta-analysis sought to assess the current evidence. METHODS AND RESULTS: Electronic searches were performed using six databases from their inception to December 2013, identifying all relevant randomized trials and observational studies comparing BA vs. LA surgical ablation AFpatients undertaking cardiac surgery. In 10 included studies, 2225 patient results were available for analysis to compare BA (n = 888) vs. LA (n = 1337) ablation. Sinus rhythm prevalence was higher in the BA cohort compared with the LA cohort at 6-month and 12-month follow-up, but similar beyond 1 year. Permanent pacemaker implantations were higher in the BA cohort, but 30-day and late mortality, neurological events, and reoperation for bleeding were similar between BA and LA groups. CONCLUSIONS: Biatrial and LA ablations produced comparable 30-day and late mortality but LA was associated with significantly reduced permanent pacemaker implantation rates. Biatrial ablation appeared to be more efficacious than LA ablation in achieving SR at 1 year, but this difference was not maintained beyond 1 year. Trends appear to be driven by the preferential selection of long-standing and persistent AFpatients for the BA approach. Future randomized studies of adequate follow-up are required to validate risks and benefits of BA vs. LA surgical ablation. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Kevin Phan; Laurent Pison; Nelson Wang; Aran Kanagaratnam; Tristan D Yan; Bart Maesen; Jos G Maessen; Harry J Crijns; Mark La Meir Journal: J Thorac Dis Date: 2017-09 Impact factor: 2.895
Authors: Maciej Rachwalik; Dorota Zyśko; Grzegorz Bielicki; Marta Obremska; Anna Goździk; Wojciech Kustrzycki Journal: Kardiochir Torakochirurgia Pol Date: 2015-12-30