Literature DB >> 2533663

ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane.

Y C Awasthi1, S V Singh, H Ahmad, L W Wronski, S K Srivastava, E F LaBelle.   

Abstract

We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione-xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.

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Year:  1989        PMID： 2533663     DOI： 10.1007/bf00228088

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  19 in total

1.  Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown.

Authors:  G C MILLS
Journal:  J Biol Chem       Date:  1957-11       Impact factor: 5.157

2.  Evidence for different transport systems for oxidized glutathione and S-dinitrophenyl glutathione in human erythrocytes.

Authors:  E F LaBelle; S V Singh; S K Srivastava; Y C Awasthi
Journal:  Biochem Biophys Res Commun       Date:  1986-09-14       Impact factor: 3.575

Review 3.  The glutathione S-transferases: a group of multifunctional detoxification proteins.

Authors:  W B Jakoby
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1978

4.  The transport of oxidized glutathione from human erythrocytes.

Authors:  S K Srivastava; E Beutler
Journal:  J Biol Chem       Date:  1969-01-10       Impact factor: 5.157

5.  Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

Authors:  H S Penefsky
Journal:  J Biol Chem       Date:  1977-05-10       Impact factor: 5.157

6.  Mercapturic acid pathway enzymes in bovine ocular lens, cornea, retina and retinal pigmented epithelium.

Authors:  R P Saneto; Y C Awasthi; S K Srivastava
Journal:  Exp Eye Res       Date:  1982-08       Impact factor: 3.467

7.  Enzymatic conjugation of erythrocyte glutathione with 1-chloro-2,4-dinitrobenzene: the fate of glutathione conjugate in erythrocytes and the effect of glutathione depletion on hemoglobin.

Authors:  Y C Awasthi; H S Garg; D D Dao; C A Partridge; S K Srivastava
Journal:  Blood       Date:  1981-10       Impact factor: 22.113

Review 8.  Subunit structure of human and rat glutathione S-transferases.

Authors:  Y C Awasthi; S V Singh
Journal:  Comp Biochem Physiol B       Date:  1985

9.  Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

Authors:  B Mannervik; P Alin; C Guthenberg; H Jensson; M K Tahir; M Warholm; H Jörnvall
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

10.  Detoxification of xenobiotics by glutathione S-transferases in erythrocytes: the transport of the conjugate of glutathione and 1-chloro-2,4-dinitrobenzene.

Authors:  Y C Awasthi; G Misra; D K Rassin; S K Srivastava
Journal:  Br J Haematol       Date:  1983-11       Impact factor: 6.998
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  1 in total

Review 1.  Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization.

Authors:  Jasleen K Sodhi; Leslie Z Benet
Journal:  J Med Chem       Date:  2021-03-25       Impact factor: 7.446
  1 in total

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