Marie Tisserand1, Pierre Seners1, Guillaume Turc1, Laurence Legrand1, Marc-Antoine Labeyrie1, Sylvain Charron1, Jean-François Méder1, Jean-Louis Mas1, Catherine Oppenheim1, Jean-Claude Baron2. 1. From the INSERM UMR S894, Sorbonne Paris Cité, Service de Neuroradiologie (M.T., L.L., M.-A.L., S.C., J.-F.M., C.O.) and INSERM UMR S894, Sorbonne Paris Cité, Service de Neurologie (P.S., G.T., J.-L.M., J.-C.B.), Centre Hospitalier Sainte-Anne, Paris, France. 2. From the INSERM UMR S894, Sorbonne Paris Cité, Service de Neuroradiologie (M.T., L.L., M.-A.L., S.C., J.-F.M., C.O.) and INSERM UMR S894, Sorbonne Paris Cité, Service de Neurologie (P.S., G.T., J.-L.M., J.-C.B.), Centre Hospitalier Sainte-Anne, Paris, France. jean-claude.baron@inserm.fr.
Abstract
BACKGROUND AND PURPOSE: Unstable clinical course characterizes the first 24 hours after thrombolysis for anterior circulation stroke, including early neurological deterioration (END), a secondary complication consistently predictive of poor outcome. Apart from straightforward causes, such as intracerebral hemorrhage and malignant edema, the mechanism of END remains unclear in the majority of cases (ENDunexplained). Based on the core/penumbra model, we tested the hypothesis that ENDunexplained is caused by infarct growth beyond the initial penumbra and assessed the associated vascular patterns. METHODS: From our database of consecutive thrombolyzed patients (n=309), we identified 10 ENDunexplained cases who had undergone both admission and 24-hour MRI. Diffusion-weighted imaging lesion growth both within and beyond the acute penumbra (Tmax>6 seconds) was mapped voxelwise. These 10 cases were compared with 30 no-END controls extracted from the database blinded to 24-hour diffusion-weighted imaging to individually match cases (3/case) according to 4 previously identified clinical and imaging variables. RESULTS: As predicted, lesion growth beyond initial penumbra was present in 9 of 10 ENDunexplained patients (substantial in 8) and its volume was significantly larger in cases than controls (2P=0.047). All ENDunexplained cases had proximal arterial occlusion initially, of which only 2 had recanalized at 24 hours. CONCLUSIONS: In this exploratory study, most instances of ENDunexplained were related to diffusion-weighted imaging growth beyond acute penumbra. Consistent presence of proximal occlusion at admission and lack of recanalization at 24 hours in most cases suggest that hemodynamic factors played a key role, via for instance systemic instability/collateral failure or secondary thromboembolic processes. Preventing END after tissue-type plasminogen activator using, eg, early antithrombotics may therefore be feasible.
BACKGROUND AND PURPOSE: Unstable clinical course characterizes the first 24 hours after thrombolysis for anterior circulation stroke, including early neurological deterioration (END), a secondary complication consistently predictive of poor outcome. Apart from straightforward causes, such as intracerebral hemorrhage and malignant edema, the mechanism of END remains unclear in the majority of cases (ENDunexplained). Based on the core/penumbra model, we tested the hypothesis that ENDunexplained is caused by infarct growth beyond the initial penumbra and assessed the associated vascular patterns. METHODS: From our database of consecutive thrombolyzed patients (n=309), we identified 10 ENDunexplained cases who had undergone both admission and 24-hour MRI. Diffusion-weighted imaging lesion growth both within and beyond the acute penumbra (Tmax>6 seconds) was mapped voxelwise. These 10 cases were compared with 30 no-END controls extracted from the database blinded to 24-hour diffusion-weighted imaging to individually match cases (3/case) according to 4 previously identified clinical and imaging variables. RESULTS: As predicted, lesion growth beyond initial penumbra was present in 9 of 10 ENDunexplained patients (substantial in 8) and its volume was significantly larger in cases than controls (2P=0.047). All ENDunexplained cases had proximal arterial occlusion initially, of which only 2 had recanalized at 24 hours. CONCLUSIONS: In this exploratory study, most instances of ENDunexplained were related to diffusion-weighted imaging growth beyond acute penumbra. Consistent presence of proximal occlusion at admission and lack of recanalization at 24 hours in most cases suggest that hemodynamic factors played a key role, via for instance systemic instability/collateral failure or secondary thromboembolic processes. Preventing END after tissue-type plasminogen activator using, eg, early antithrombotics may therefore be feasible.
Authors: M P Messer; S Schönenberger; M A Möhlenbruch; J Pfaff; C Herweh; P A Ringleb; S Nagel Journal: AJNR Am J Neuroradiol Date: 2017-04-13 Impact factor: 3.825
Authors: Latisha K Ali; Julius K Weng; Sidney Starkman; Jeffrey L Saver; Doojin Kim; Bruce Ovbiagele; Brian H Buck; Nerses Sanossian; Paul Vespa; Oh Young Bang; Reza Jahan; Gary R Duckwiler; Fernando Viñuela; David S Liebeskind Journal: Interv Neurol Date: 2016-09-30
Authors: Michael V Mazya; Charith Cooray; Kennedy R Lees; Danilo Toni; Gary A Ford; Michal Bar; Senta Frol; Tiago Moreira; Lakshmanan Sekaran; Viktor Švigelj; Nils Wahlgren; Niaz Ahmed Journal: Eur Stroke J Date: 2017-11-29