Literature DB >> 25335841

Microbicides and their potential as a catalyst for multipurpose sexual and reproductive health technologies.

Q Abdool Karim1, C Baxter, S Abdool Karim.   

Abstract

There is an urgent need for technologies to prevent sexual acquisition of HIV infection in young women in sub-Saharan Africa. After two decades of 11 pivotal trials of seven products, anti-retroviral-based topical microbicides are showing promise. Building on the CAPRISA 004 trial findings, several trials of new anti-viral agents, novel delivery mechanisms and combination/multipurpose products that address challenges of adherence and meet the sexual and reproductive health needs of men and women, including preventing HIV infection, are underway.
© 2014 Royal College of Obstetricians and Gynaecologists.

Entities:  

Keywords:  HIV prevention; microbicide; tenofovir gel; women

Mesh：

Substances：

Year:  2014        PMID： 25335841      PMCID： PMC4206831          DOI： 10.1111/1471-0528.12843

Source DB:  PubMed          Journal:  BJOG        ISSN： 1470-0328            Impact factor:   6.531


  44 in total

1.  Anal and dry sex in commercial sex work, and relation to risk for sexually transmitted infections and HIV in Meru, Kenya.

Authors:  M Schwandt; C Morris; A Ferguson; E Ngugi; S Moses
Journal:  Sex Transm Infect       Date:  2006-06-21       Impact factor: 3.519

2.  Discrepancies between self-report and objective measures for stimulant drug use in HIV: cognitive, medication adherence and psychological correlates.

Authors:  M J Reinhard; C H Hinkin; T R Barclay; A J Levine; S Marion; S A Castellon; D Longshore; T Newton; R S Durvasula; M N Lam; H Myers
Journal:  Addict Behav       Date:  2007-04-14       Impact factor: 3.913

3.  Prospective study of hormonal contraception and women's risk of HIV infection in South Africa.

Authors:  Landon Myer; Lynette Denny; Thomas C Wright; Louise Kuhn
Journal:  Int J Epidemiol       Date:  2006-12-14       Impact factor: 7.196

Review 4.  Heterosexual anal intercourse: prevalence, cultural factors, and HIV infection and other health risks, Part I.

Authors:  D T Halperin
Journal:  AIDS Patient Care STDS       Date:  1999-12       Impact factor: 5.078

5.  Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial.

Authors:  Lut Van Damme; Gita Ramjee; Michel Alary; Bea Vuylsteke; Verapol Chandeying; Helen Rees; Pachara Sirivongrangson; Léonard Mukenge-Tshibaka; Virginie Ettiègne-Traoré; Charn Uaheowitchai; Salim S Abdool Karim; Benoît Mâsse; Jos Perriëns; Marie Laga
Journal:  Lancet       Date:  2002-09-28       Impact factor: 79.321

6.  Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges.

Authors:  James M Smith; Rachna Rastogi; Ryan S Teller; Priya Srinivasan; Pedro M M Mesquita; Umadevi Nagaraja; Janet M McNicholl; R Michael Hendry; Chuong T Dinh; Amy Martin; Betsy C Herold; Patrick F Kiser
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

7.  A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases.

Authors:  R E Roddy; L Zekeng; K A Ryan; U Tamoufé; S S Weir; E L Wong
Journal:  N Engl J Med       Date:  1998-08-20       Impact factor: 91.245

8.  Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes.

Authors:  J Kreiss; E Ngugi; K Holmes; J Ndinya-Achola; P Waiyaki; P L Roberts; I Ruminjo; R Sajabi; J Kimata; T R Fleming
Journal:  JAMA       Date:  1992 Jul 22-29       Impact factor: 56.272

9.  Seroprevalence of HIV infection in rural South Africa.

Authors:  Q Abdool Karim; S S Abdool Karim; B Singh; R Short; S Ngxongo
Journal:  AIDS       Date:  1992-12       Impact factor: 4.177

10.  Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women.

Authors:  Jared M Baeten; Sarah Benki; Vrasha Chohan; Ludo Lavreys; R Scott McClelland; Kishorchandra Mandaliya; Jeckoniah O Ndinya-Achola; Walter Jaoko; Julie Overbaugh
Journal:  AIDS       Date:  2007-08-20       Impact factor: 4.177
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  2 in total

1.  How Presentation of Drug Detection Results Changed Reports of Product Adherence in South Africa, Uganda and Zimbabwe.

Authors:  Petina Musara; Elizabeth T Montgomery; Nyaradzo M Mgodi; Kubashni Woeber; Carolyne A Akello; Miriam Hartmann; Helen Cheng; Lisa Levy; Ariana Katz; Cynthia I Grossman; Z Mike Chirenje; Ariane van der Straten; Barbara Mensch
Journal:  AIDS Behav       Date:  2018-03

2.  Understanding women's motivations to participate in MTN-003/VOICE, a phase 2b HIV prevention trial with low adherence.

Authors:  Ariana W K Katz; Barbara S Mensch; Kubashni Woeber; Petina Musara; Juliane Etima; Ariane van der Straten
Journal:  BMC Womens Health       Date:  2019-01-25       Impact factor: 2.809
  2 in total

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