Ilma Cely de Amorim Ribeiro1, Carlos Alberto Soares da Costa2, Vivian Alves Pereira3, Gilson Teles Boaventura4, Mauricio Alves Chagas5. 1. Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University. Brasil.. ilmavetuff@gmail.com. 2. Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University. Brasil.. carlosnut@ibest.com.br. 3. Department of Nutrition and Dietetics, Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Rio de Janeiro, Brazil.. ap_vivian@hotmail.com. 4. Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University. Brasil.. gilsontb@gmail.com. 5. Department of Nutrition and Dietetics, Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Rio de Janeiro, Brazil.. chagas.m@gmail.com.
Abstract
BACKGROUND: The chronic use of steroid hormones can lead to alterations in the lipid profile such as an increase in LDL and decrease in HDL levels . The effect of flaxseed on lipid profiles has been widely investigated. AIM: Evaluate the lipid profile of adult male Wistar rats fed with flax based meals and submitted to androgenic hyperstimulation. MATERIAL AND METHODS: Forty Wistar rats were divided into 4 groups of 10 animals: the Control group (CG); Flax group (FG) fed a flaxseed flour-based meal; Induced group (IG); and the Induced group (IGF) that was fed a flaxseed flour-based meal. The induction was done by using silicone pellets filled with testosterone propionate (1mg), sealed with a surgical adhesive and substituted every 4 weeks. RESULTS: Triglycerides (FG: 71.16 ± 21.95; IG: 99.16 ± 26.00 and IGF: 86.33 ± 27.16 mg/dL) and HDL-cholesterol (FG: 23.05 ± 1.67; IG: 29.06 ± 7.24 and IGF: 26.06 ± 3.56 mg/dL) were significantly lower in the experimental groups. The FG and IGF (41.16 ± 3.97 and 49.66 ± 11.25 mg/dL, respectively) showed significantly lower levels of cholesterol than the other groups(CG: 78,85 ± 11.58 and IG: 70,83 ± 14.85 mg/dL). Regarding LDL levels, the IG showed significantly higher concentrations (21,93 ± 8,84 mg/dL) than the others groups (CG: 7,81 ± 5,37; FG: 3,88 ± 1,32 and IGF: 6,66 ± 7,24 mg/dL). CONCLUSIONS: The flaxseed has a relevant effect on the lipid profile of animals submitted to androgenic hyperstimulation. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
BACKGROUND: The chronic use of steroid hormones can lead to alterations in the lipid profile such as an increase in LDL and decrease in HDL levels . The effect of flaxseed on lipid profiles has been widely investigated. AIM: Evaluate the lipid profile of adult male Wistar rats fed with flax based meals and submitted to androgenic hyperstimulation. MATERIAL AND METHODS: Forty Wistar rats were divided into 4 groups of 10 animals: the Control group (CG); Flax group (FG) fed a flaxseed flour-based meal; Induced group (IG); and the Induced group (IGF) that was fed a flaxseed flour-based meal. The induction was done by using silicone pellets filled with testosterone propionate (1mg), sealed with a surgical adhesive and substituted every 4 weeks. RESULTS:Triglycerides (FG: 71.16 ± 21.95; IG: 99.16 ± 26.00 and IGF: 86.33 ± 27.16 mg/dL) and HDL-cholesterol (FG: 23.05 ± 1.67; IG: 29.06 ± 7.24 and IGF: 26.06 ± 3.56 mg/dL) were significantly lower in the experimental groups. The FG and IGF (41.16 ± 3.97 and 49.66 ± 11.25 mg/dL, respectively) showed significantly lower levels of cholesterol than the other groups(CG: 78,85 ± 11.58 and IG: 70,83 ± 14.85 mg/dL). Regarding LDL levels, the IG showed significantly higher concentrations (21,93 ± 8,84 mg/dL) than the others groups (CG: 7,81 ± 5,37; FG: 3,88 ± 1,32 and IGF: 6,66 ± 7,24 mg/dL). CONCLUSIONS: The flaxseed has a relevant effect on the lipid profile of animals submitted to androgenic hyperstimulation. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Waseem Khalid; Muhammad Sajid Arshad; Muhammad Modassar Ali Nawaz Ranjha; Maria Barbara Różańska; Shafeeqa Irfan; Bakhtawar Shafique; Muhammad Abdul Rahim; Muhammad Zubair Khalid; Gholamreza Abdi; Przemysław Łukasz Kowalczewski Journal: Open Life Sci Date: 2022-09-08 Impact factor: 1.311