Literature DB >> 25333923

N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes.

Y Wang1, S R McAlpine.   

Abstract

Classic oncogenic heat shock protein 90 (Hsp90) inhibitors target the N-terminus of the protein, triggering a survival mechanism in cancer cells referred to as the heat shock response (HSR). Inhibiting Hsp90 by modulating the C-terminus does not trigger a HSR, making it a highly attractive chemotherapeutic approach.

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Year:  2015        PMID： 25333923     DOI： 10.1039/c4cc07284g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  16 in total

Review 1.  The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis.

Authors:  Kristoffer R Brandvold; Richard I Morimoto
Journal:  J Mol Biol       Date:  2015-05-21       Impact factor: 5.469

2.  Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System.

Authors:  Jongmin Park; Hyungsoon Im; Seonki Hong; Cesar M Castro; Ralph Weissleder; Hakho Lee
Journal:  ACS Photonics       Date:  2017-11-03       Impact factor: 7.529

Review 3.  Inhibitors and chemical probes for molecular chaperone networks.

Authors:  Jason E Gestwicki; Hao Shao
Journal:  J Biol Chem       Date:  2018-09-13       Impact factor: 5.157

Review 4.  Strategies to Enhance Radiosensitivity to Heavy Ion Radiation Therapy.

Authors:  Younghyun Lee; Ryuichi Okayasu
Journal:  Int J Part Ther       Date:  2018-09-21

5.  Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.

Authors:  Sanil Bhatia; Daniela Diedrich; Benedikt Frieg; Heinz Ahlert; Stefan Stein; Bertan Bopp; Franziska Lang; Tao Zang; Tobias Kröger; Thomas Ernst; Gesine Kögler; Andreas Krieg; Steffen Lüdeke; Hana Kunkel; Ana J Rodrigues Moita; Matthias U Kassack; Viktoria Marquardt; Friederike V Opitz; Marina Oldenburg; Marc Remke; Florian Babor; Manuel Grez; Andreas Hochhaus; Arndt Borkhardt; Georg Groth; Luitgard Nagel-Steger; Joachim Jose; Thomas Kurz; Holger Gohlke; Finn K Hansen; Julia Hauer
Journal:  Blood       Date:  2018-05-03       Impact factor: 22.113

6.  Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors.

Authors:  Katherine M Byrd; Chitra Subramanian; Jacqueline Sanchez; Hashim F Motiwala; Weiya Liu; Mark S Cohen; Jeffrey Holzbeierlein; Brian S J Blagg
Journal:  Chemistry       Date:  2016-04-01       Impact factor: 5.236

7.  Synthesis and Biological Evaluation of Stilbene Analogues as Hsp90 C-Terminal Inhibitors.

Authors:  Katherine M Byrd; Caitlin N Kent; Brian S J Blagg
Journal:  ChemMedChem       Date:  2017-11-30       Impact factor: 3.466

8.  Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains.

Authors:  Jeanette R McConnell; H Jane Dyson; Shelli R McAlpine
Journal:  RSC Med Chem       Date:  2021-02-15

9.  X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response.

Authors:  Zhixin Zhao; Jianming Zhu; Haitian Quan; Guimin Wang; Bo Li; Weiliang Zhu; Chengying Xie; Liguang Lou
Journal:  Oncotarget       Date:  2016-05-17

10.  CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.

Authors:  Xiao-Li Xu; Qi-chao Bao; Jian-Min Jia; Fang Liu; Xiao-Ke Guo; Ming-ye Zhang; Jin-lian Wei; Meng-chen Lu; Li-li Xu; Xiao-Jin Zhang; Qi-Dong You; Hao-Peng Sun
Journal:  Sci Rep       Date:  2016-01-08       Impact factor: 4.379
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