| Literature DB >> 25332973 |
Syeda Afroze1, Fanyin Meng1, Kendal Jensen1, Kelly McDaniel1, Kinan Rahal1, Paolo Onori1, Eugenio Gaudio1, Gianfranco Alpini1, Shannon S Glaser1.
Abstract
Secretin is secreted by S cells in the small intestine and affects the function of a number of organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. In addition to regulating the secretion of a number of epithelia (e.g., in the pancreas and biliary epithelium in the liver), secretin exerts trophic effects in several cell types. In this article, we will provide a comprehensive review on the multiple roles of secretin and SR signaling in the regulation of epithelial functions in various organ systems with particular emphasis in the liver. We will discuss the role of secretin and its receptor in health and biliary disease pathogenesis. Finally, we propose future areas of research for the further evaluation of the secretin/secretin receptor axis in liver pathophysiology.Entities:
Keywords: Secretin; Secretin receptors
Year: 2013 PMID： 25332973 PMCID： PMC4200670 DOI： 10.3978/j.issn.2305-5839.2012.12.01
Source DB: PubMed Journal: Ann Transl Med ISSN： 2305-5839