Literature DB >> 25332906

MicroRNAs in lung cancer.

Pooja Joshi1, Justin Middleton1, Young-Jun Jeon1, Michela Garofalo1.   

Abstract

MicroRNAs have become recognized as key players in the development of cancer. They are a family of small non-coding RNAs that can negatively regulate the expression of cancer-related genes by sequence-selective targeting of mRNAs, leading to either mRNA degradation or translational repression. Lung cancer is the leading cause of cancer-related death worldwide with a substantially low survival rate. MicroRNAs have been confirmed to play roles in lung cancer development, epithelial-mesenchymal transition and response to therapy. They are also being studied for their future use as diagnostic and prognostic biomarkers and as potential therapeutic targets. In this review we focus on the role of dysregulated microRNA expression in lung tumorigenesis. We also discuss the role of microRNAs in therapeutic resistance and as biomarkers. We further look into the progress made and challenges remaining in using microRNAs for therapy in lung cancer.

Entities:  

Keywords:  Lung cancer; MiRNA; MicroRNA

Year:  2014        PMID： 25332906      PMCID： PMC4202482          DOI： 10.5662/wjm.v4.i2.59

Source DB:  PubMed          Journal:  World J Methodol        ISSN： 2222-0682


  145 in total

1.  miRNA expression profiling of lung adenocarcinomas: correlation with mutational status.

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Journal:  Mod Pathol       Date:  2010-09-03       Impact factor: 7.842

2.  Effect of miR-34b overexpression on the radiosensitivity of non-small cell lung cancer cell lines.

Authors:  Joana Balça-Silva; Sílvia Sousa Neves; Ana Cristina Gonçalves; Ana Margarida Abrantes; João Casalta-Lopes; Maria Filomena Botelho; Ana Bela Sarmento-Ribeiro; Henriqueta Coimbra Silva
Journal:  Anticancer Res       Date:  2012-05       Impact factor: 2.480

3.  Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells.

Authors:  Leina Ma; Jia Liu; Junjie Shen; Li Liu; Jia Wu; Wei Li; Jingjing Luo; Qing Chen; Cheng Qian
Journal:  Cancer Biol Ther       Date:  2010-04-01       Impact factor: 4.742

4.  Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.

Authors:  Nozomu Yanaihara; Natasha Caplen; Elise Bowman; Masahiro Seike; Kensuke Kumamoto; Ming Yi; Robert M Stephens; Aikou Okamoto; Jun Yokota; Tadao Tanaka; George Adrian Calin; Chang-Gong Liu; Carlo M Croce; Curtis C Harris
Journal:  Cancer Cell       Date:  2006-03       Impact factor: 31.743

5.  miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma.

Authors:  Andrea L Kasinski; Frank J Slack
Journal:  Cancer Res       Date:  2012-09-10       Impact factor: 12.701

6.  Sputum microRNA profiling: a novel approach for the early detection of non-small cell lung cancer.

Authors:  Wilson H Roa; Julian O Kim; Rene Razzak; Hongfei Du; Linghong Guo; Ravinder Singh; Sayf Gazala; Sunita Ghosh; Eric Wong; Anil A Joy; James Z Xing; Eric L Bedard
Journal:  Clin Invest Med       Date:  2012-10-06       Impact factor: 0.825

7.  Suppression of non-small cell lung tumor development by the let-7 microRNA family.

Authors:  Madhu S Kumar; Stefan J Erkeland; Ryan E Pester; Cindy Y Chen; Margaret S Ebert; Phillip A Sharp; Tyler Jacks
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-28       Impact factor: 11.205

8.  A gold nanoparticle platform for the delivery of functional microRNAs into cancer cells.

Authors:  Rajib Ghosh; Lalithya C Singh; Jason M Shohet; Preethi H Gunaratne
Journal:  Biomaterials       Date:  2012-10-27       Impact factor: 12.479

9.  Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles.

Authors:  Amanda Tivnan; Wayne Shannon Orr; Vladimir Gubala; Robert Nooney; David E Williams; Colette McDonagh; Suzanne Prenter; Harry Harvey; Raquel Domingo-Fernández; Isabella M Bray; Olga Piskareva; Catherine Y Ng; Holger N Lode; Andrew M Davidoff; Raymond L Stallings
Journal:  PLoS One       Date:  2012-05-25       Impact factor: 3.240

10.  MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer.

Authors:  Michela Garofalo; Young-Jun Jeon; Gerard J Nuovo; Justin Middleton; Paola Secchiero; Pooja Joshi; Hansjuerg Alder; Natalya Nazaryan; Gianpiero Di Leva; Giulia Romano; Melissa Crawford; Patrick Nana-Sinkam; Carlo M Croce
Journal:  PLoS One       Date:  2013-06-21       Impact factor: 3.240
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  29 in total

1.  miR-15a enhances the anticancer effects of cisplatin in the resistant non-small cell lung cancer cells.

Authors:  Vildan Bozok Çetintaş; Aslı Tetik Vardarlı; Zekeriya Düzgün; Burçin Tezcanlı Kaymaz; Eda Açıkgöz; Hüseyin Aktuğ; Buket Kosova Can; Cumhur Gündüz; Zuhal Eroğlu
Journal:  Tumour Biol       Date:  2015-08-28

2.  MiR-101 inhibits the proliferation and metastasis of lung cancer by targeting zinc finger E-box binding homeobox 1.

Authors:  Le Han; Wenjuan Chen; Yanmin Xia; Yangrong Song; Zheng Zhao; Hao Cheng; Tao Jiang
Journal:  Am J Transl Res       Date:  2018-04-15       Impact factor: 4.060

3.  [Specific microRNA expression profiles of lung adenocarcinoma in Xuanwei region and bioinformatic analysis for predicting their target genes and related signaling pathways].

Authors:  Shuai Chen; Yong-Chun Zhou; Ying Chen; Xiao-Bo Chen; Guang-Jian Li; Jia-Peng Yang; Yu-Jie Lei; Guang-Qiang Zhao; Qiu-Bo Huang; Chang-Shao Yang; Ya-Xi DU; Yun-Chao Huang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2016-02-20

4.  [Expression profile of miR-501-5p in lung adenocarcinoma patients from Xuanwei area].

Authors:  Shuai Chen; Yong-Chun Zhou; Ying Chen; Xiao-Bo Chen; Guang-Jian Li; Yu-Jie Lei; Lin-Wei Tian; Guang-Qiang Zhao; Qiubo Huang; Yunc-Hao Huang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2017-03-20

5.  miR-126/VCAM-1 regulation by naringin suppresses cell growth of human non-small cell lung cancer.

Authors:  Mingjiu Chen; Weilin Peng; Shifeng Hu; Jie Deng
Journal:  Oncol Lett       Date:  2018-07-24       Impact factor: 2.967

6.  MicroRNA-146a-5p enhances ginsenoside Rh2-induced anti-proliferation and the apoptosis of the human liver cancer cell line HepG2.

Authors:  Weiwen Chen; Shuai Chu; Haixia Li; Yurong Qiu
Journal:  Oncol Lett       Date:  2018-07-31       Impact factor: 2.967

7.  Role of plasma MicroRNAs in the early diagnosis of non-small-cell lung cancers: a case-control study.

Authors:  Xin Wang; Xiuyi Zhi; Yi Zhang; Guangyu An; Guosheng Feng
Journal:  J Thorac Dis       Date:  2016-07       Impact factor: 2.895

8.  MiR-302a-5p suppresses cell proliferation and invasion in non-small cell lung carcinoma by targeting ITGA6.

Authors:  Wei Chen; Xibing Zhuang; Ruixue Qi; Tiankui Qiao
Journal:  Am J Transl Res       Date:  2019-07-15       Impact factor: 4.060

9.  MiR-374a suppresses lung adenocarcinoma cell proliferation and invasion by targeting TGFA gene expression.

Authors:  Haijian Wu; Yan Liu; Xiao Ou Shu; Qiuyin Cai
Journal:  Carcinogenesis       Date:  2016-03-31       Impact factor: 4.944

10.  miRNA-296-3p modulates chemosensitivity of lung cancer cells by targeting CX3CR1.

Authors:  Wen Luo; Yuanlong Lin; Shanshan Meng; Yuening Guo; Jiawen Zhang; Wei Zhang
Journal:  Am J Transl Res       Date:  2016-04-15       Impact factor: 4.060
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