| Literature DB >> 25332627 |
Suganya K Reddy1, Jinkala Sree Rekha1, Sajini Elizabeth Jacob1, Debdatta Basu1.
Abstract
Castleman disease (CD) is a benign heterogenous lymphoproliferative disorder presenting with varied clinical manifestations. Histomorphologically, two distinct variants are known, hyaline vascular type and plasma cell type. CD is reported to be associated with lymphomas. Though Non Hodgkin lymphoma is more commonly associated with CD, its association with Hodgkin lymphoma (HL) is also well known and documented. Many a times, CD obscures or masks the underlying lymphomas thus delaying the diagnosis. There are also reports of HL showing Castleman like features. We report a case of HL with Castleman like features which posed diagnostic difficulty owing to the fragmented nature and tiny size of the initial lymph node biopsy. Striking peripheral blood rouleaux formation which was seen in our case along with bone marrow plasmacytosis has not been described in the previously diagnosed cases.Entities:
Keywords: Castleman disease; Hodgkin lymphoma; Immunohistochemistry
Year: 2014 PMID: 25332627 PMCID: PMC4192259 DOI: 10.1007/s12288-014-0429-6
Source DB: PubMed Journal: Indian J Hematol Blood Transfus ISSN: 0971-4502 Impact factor: 0.900