Literature DB >> 25332565

Myelodysplasia in children: report of 2 cases.

M C Savithri1, K P Kavitha2, Vanesa John2.   

Abstract

Myelodysplasia in children is rare. We report two cases presenting with pancytopaenia and macrocytosis with additional features suggestive of Fanconi anemia which is an autosomal recessive disorder in which there is progressive bone marrow failure and increased predisposition to malignancies especially AML. Hypersensitivity of FA cells to the chromosome-breaking effect of cross-linking agents provides a reliable cellular marker for the diagnosis of this disorder.

Entities:  

Keywords:  Fanconi anemia; Pancytopenia; Pediatric myelodysplasia

Year:  2013        PMID： 25332565      PMCID： PMC4192201          DOI： 10.1007/s12288-013-0304-x

Source DB:  PubMed          Journal:  Indian J Hematol Blood Transfus        ISSN： 0971-4502            Impact factor:   0.900


  5 in total

1.  Fanconi anemia: myelodysplasia as a predictor of outcome.

Authors:  B P Alter; J P Caruso; R A Drachtman; T Uchida; G V Velagaleti; M T Elghetany
Journal:  Cancer Genet Cytogenet       Date:  2000-03

Review 2.  Myelodysplasia and myeloproliferative disorders in children.

Authors:  Robert W McKenna
Journal:  Am J Clin Pathol       Date:  2004-12       Impact factor: 2.493

Review 3.  Fanconi anemia and its diagnosis.

Authors:  Arleen D Auerbach
Journal:  Mutat Res       Date:  2009-02-28       Impact factor: 2.433

4.  Diagnosis of Fanconi anemia in patients with bone marrow failure.

Authors:  Fernando O Pinto; Thierry Leblanc; Delphine Chamousset; Gwenaelle Le Roux; Benoit Brethon; Bruno Cassinat; Jérôme Larghero; Jean-Pierre de Villartay; Dominique Stoppa-Lyonnet; André Baruchel; Gérard Socié; Eliane Gluckman; Jean Soulier
Journal:  Haematologica       Date:  2009-03-10       Impact factor: 9.941

5.  Spectrum of anomalies in Fanconi anaemia.

Authors:  A Glanz; F C Fraser
Journal:  J Med Genet       Date:  1982-12       Impact factor: 6.318
  5 in total

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