François Bénard1, Stefan K Zeisler2, Milan Vuckovic3, Kuo-Shyan Lin4, Zhengxing Zhang3, Nadine Colpo3, Xinchi Hou5, Thomas J Ruth6, Paul Schaffer7. 1. BC Cancer Agency, Vancouver, British Columbia, Canada Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada fbenard@bccrc.ca. 2. TRIUMF, Vancouver, British Columbia, Canada; and. 3. BC Cancer Agency, Vancouver, British Columbia, Canada. 4. BC Cancer Agency, Vancouver, British Columbia, Canada Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada. 5. Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada. 6. BC Cancer Agency, Vancouver, British Columbia, Canada TRIUMF, Vancouver, British Columbia, Canada; and. 7. Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada TRIUMF, Vancouver, British Columbia, Canada; and.
Abstract
UNLABELLED: We report a kit-based approach for the purification of sodium pertechnetate ((99m)TcO4 (-)) from solutions with high MoO4 (2-) content. METHODS: Cross-linked polyethylene glycol resins (ChemMatrix) were used to separate (99m)Tc and molybdenum in 4N NaOH. The resins were loaded at various flow rates and eluted with water to release (99m)Tc. The (99m)Tc solution was passed through a cation exchange resin and an alumina cartridge, followed by saline elution. This process was tested with cyclotron-produced (99m)Tc using an automated system and disposable kits. RESULTS: Optimal results were obtained by loading 500 mg of resin at flow rates of up to 3.1 mL/min, with quantitative extraction of (99m)Tc from the molybdate solution and complete release of (99m)Tc after elution with water. The automated system was highly efficient at isolating Na(99m)TcO4 within minutes, with a recovery rate of 92.7% ± 1.1% (mean ± SD) using cyclotron-produced (99m)Tc. CONCLUSION: ChemMatrix resins were highly effective at separating (99m)TcO4 (-) from molybdate solutions.
UNLABELLED: We report a kit-based approach for the purification of sodium pertechnetate ((99m)TcO4 (-)) from solutions with high MoO4 (2-) content. METHODS: Cross-linked polyethylene glycol resins (ChemMatrix) were used to separate (99m)Tc and molybdenum in 4N NaOH. The resins were loaded at various flow rates and eluted with water to release (99m)Tc. The (99m)Tc solution was passed through a cation exchange resin and an alumina cartridge, followed by saline elution. This process was tested with cyclotron-produced (99m)Tc using an automated system and disposable kits. RESULTS: Optimal results were obtained by loading 500 mg of resin at flow rates of up to 3.1 mL/min, with quantitative extraction of (99m)Tc from the molybdate solution and complete release of (99m)Tc after elution with water. The automated system was highly efficient at isolating Na(99m)TcO4 within minutes, with a recovery rate of 92.7% ± 1.1% (mean ± SD) using cyclotron-produced (99m)Tc. CONCLUSION: ChemMatrix resins were highly effective at separating (99m)TcO4 (-) from molybdate solutions.