Alexandra D Frolkis1, Debra S Lipton2, Kirsten M Fiest3, María E Negrón4, Jonathan Dykeman3, Jennifer deBruyn2, Nathalie Jette3, Talia Frolkis2, Ali Rezaie1, Cynthia H Seow1, Remo Panaccione2, Subrata Ghosh2, Gilaad G Kaplan1. 1. 1] Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada [2] Department of Community Health Sciences and Institute for Public Health, University of Calgary, Calgary, Alberta, Canada. 2. Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. 3. 1] Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada [2] Department of Community Health Sciences and Institute for Public Health, University of Calgary, Calgary, Alberta, Canada [3] Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. 4. 1] Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada [2] Department of Production Animal Health, University of Calgary, Calgary, Alberta, Canada.
Abstract
OBJECTIVES: Approximately 50% of Crohn's disease patients undergo an intestinal resection within 10 years of diagnosis. The risk of second surgery in Crohn's disease and the influence of time are not well characterized. We performed a systematic review and meta-analysis to establish the risk of second abdominal surgery in patients with Crohn's disease among patients who had a previous surgery. METHODS: We searched Medline, EMBASE, PubMed (March 2014), and conference proceedings for terms related to Crohn's disease and intestinal surgery. We included population-based articles (n=11) and an abstract (n=1) reporting surgical risk for the overall study period and for 5 and 10 years after the first surgery for Crohn's disease. We stratified studies by year (start year before vs. after 1980) to explore the role of time. RESULTS: For all population-based studies, the overall risk of second surgery was 28.7% (95% confidence interval (CI): 22.6-36.6%). The 5-year risk of second surgery was 24.2% (95% CI: 22.3-26.4%). The 10-year risk of second surgery was 35.0% (95% CI: 31.8-38.6%). A significant difference in the 10-year risk of second surgery was observed over time such that studies conducted after 1980 had a lower risk of second surgery (33.2%; 95% CI: 31.2-35.4%) compared with those that started before 1980 (44.6%; 95% CI: 37.7-52.7%). CONCLUSIONS: Approximately one-quarter of Crohn's disease patients who have a first surgery also have a second, and the majority of these surgeries occur within 5 years of the first surgery. The 10-year risk of second surgery is significantly decreasing over time.
OBJECTIVES: Approximately 50% of Crohn's diseasepatients undergo an intestinal resection within 10 years of diagnosis. The risk of second surgery in Crohn's disease and the influence of time are not well characterized. We performed a systematic review and meta-analysis to establish the risk of second abdominal surgery in patients with Crohn's disease among patients who had a previous surgery. METHODS: We searched Medline, EMBASE, PubMed (March 2014), and conference proceedings for terms related to Crohn's disease and intestinal surgery. We included population-based articles (n=11) and an abstract (n=1) reporting surgical risk for the overall study period and for 5 and 10 years after the first surgery for Crohn's disease. We stratified studies by year (start year before vs. after 1980) to explore the role of time. RESULTS: For all population-based studies, the overall risk of second surgery was 28.7% (95% confidence interval (CI): 22.6-36.6%). The 5-year risk of second surgery was 24.2% (95% CI: 22.3-26.4%). The 10-year risk of second surgery was 35.0% (95% CI: 31.8-38.6%). A significant difference in the 10-year risk of second surgery was observed over time such that studies conducted after 1980 had a lower risk of second surgery (33.2%; 95% CI: 31.2-35.4%) compared with those that started before 1980 (44.6%; 95% CI: 37.7-52.7%). CONCLUSIONS: Approximately one-quarter of Crohn's diseasepatients who have a first surgery also have a second, and the majority of these surgeries occur within 5 years of the first surgery. The 10-year risk of second surgery is significantly decreasing over time.
Authors: P Bayart; N Duveau; M Nachury; P Zerbib; R Gerard; J Branche; V Maunoury; Pauline Wils; A Boruchowicz; M Boualit; J-E Laberenne; O Manolache; P Desreumaux; G Pineton de Chambrun; B Pariente Journal: Dig Dis Sci Date: 2016-07-11 Impact factor: 3.199
Authors: G Pellino; D S Keller; G M Sampietro; I Angriman; M Carvello; V Celentano; F Colombo; F Di Candido; S Laureti; G Luglio; G Poggioli; M Rottoli; S Scaringi; G Sciaudone; G Sica; L Sofo; S Leone; S Danese; A Spinelli; G Delaini; F Selvaggi Journal: Tech Coloproctol Date: 2020-03-14 Impact factor: 3.781
Authors: M Rottoli; M Tanzanu; C A Manzo; M L Bacchi Reggiani; P Gionchetti; F Rizzello; L Boschi; G Poggioli Journal: Tech Coloproctol Date: 2020-04-18 Impact factor: 3.781