Literature DB >> 25330928

Emerging treatments in alopecia.

Leyre Falto-Aizpurua1, Sonal Choudhary, Antonella Tosti.   

Abstract

INTRODUCTION: Alopecia is a common concern encountered in the medical practice. Treatment approach varies according to the type and severity of alopecia. However, available treatment options have limited efficacy and several adverse effects. Presently, there are different treatment options being studied to overcome these limitations. Additionally, cellular pathways involved in the pathophysiology of alopecia are further being clarified to potentially target pathogenic molecules. AREAS COVERED: We searched the literature for recently published articles discussing new treatment options as well as mechanisms involved in alopecia. We discuss the use of stem cells, growth factors, cellular pathways and robotic hair transplant, among other emerging therapies used for alopecia. EXPERT OPINION: Future looks very promising and new effective treatments such as janus kinase inhibitors could possibly be available for alopecia areata. The stem-cell technology is advancing and companies involved in hair follicle neogenesis are starting clinical trials on patients with androgenetic alopecia.

Entities:  

Keywords:  IL-2; abatacept; alopecia areata; androgenetic alopecia; bimatoprost; chemotherapy-induced alopecia; dutasteride; excimer laser; finasteride; hair transplant; iron; janus kinase inhibitors; micropigmentation; minoxidil; pioglitazone; platelet-rich plasma; prostaglandin; retinoids; ruxolitinib; scalp cooling; scarring alopecia; stem cells; tofacitinib; trichotillomania; vitamin D; wnt pathway

Mesh:

Substances:

Year:  2014        PMID: 25330928     DOI: 10.1517/14728214.2014.974550

Source DB:  PubMed          Journal:  Expert Opin Emerg Drugs        ISSN: 1472-8214            Impact factor:   4.191


  9 in total

Review 1.  Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?

Authors:  Abdulmaged M Traish; Roberto Cosimo Melcangi; Marco Bortolato; Luis M Garcia-Segura; Michael Zitzmann
Journal:  Rev Endocr Metab Disord       Date:  2015-09       Impact factor: 6.514

Review 2.  Alopecia Areata: a Comprehensive Review of Pathogenesis and Management.

Authors:  Ralph M Trüeb; Maria Fernanda Reis Gavazzoni Dias
Journal:  Clin Rev Allergy Immunol       Date:  2018-02       Impact factor: 8.667

3.  Connarus semidecandrus Jack Exerts Anti-Alopecia Effects by Targeting 5α-Reductase Activity and an Intrinsic Apoptotic Pathway.

Authors:  Won Young Jang; Dong Seon Kim; Sang Hee Park; Ji Hye Yoon; Chae Yun Shin; Lei Huang; Ket Nang; Masphal Kry; Hye-Woo Byun; Byoung-Hee Lee; Sarah Lee; Jongsung Lee; Jae Youl Cho
Journal:  Molecules       Date:  2022-06-24       Impact factor: 4.927

4.  Advances in Stem Cell-Based Therapy for Hair Loss.

Authors:  Andjela Egger; Marjana Tomic-Canic; Antonella Tosti
Journal:  CellR4 Repair Replace Regen Reprogram       Date:  2020-09-02

5.  Bioactives in Chinese Proprietary Medicine Modulates 5α-Reductase Activity and Gene Expression Associated with Androgenetic Alopecia.

Authors:  Justin J Y Tan; Jing Pan; Lihan Sun; Junying Zhang; Chunyong Wu; Lifeng Kang
Journal:  Front Pharmacol       Date:  2017-04-13       Impact factor: 5.810

Review 6.  Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review.

Authors:  Ola Salhab; Luna Khayat; Nada Alaaeddine
Journal:  J Biomed Sci       Date:  2022-10-05       Impact factor: 12.771

7.  Hair disorder in dr. Cipto Mangunkusumo cosmetic dermatology and venereology outpatient clinic of Jakarta, Indonesia: A socio-demographic and clinical evaluation.

Authors:  Lili Legiawati; Lis Surachmiati Suseno; Irma Bernadette S Sitohang; Aditya Indra Pratama
Journal:  Dermatol Reports       Date:  2022-03-17

8.  A Proposal of an Effective Platelet-rich Plasma Protocol for the Treatment of Androgenetic Alopecia.

Authors:  Juan Ferrando; Sandra Cecilia García-García; Ana Cecilia González-de-Cossío; Lola Bou; Esperanza Navarra
Journal:  Int J Trichology       Date:  2017 Oct-Dec

Review 9.  Current advances of Dendrobium officinale polysaccharides in dermatology: a literature review.

Authors:  Linghong Guo; Jinxin Qi; Dan Du; Yin Liu; Xian Jiang
Journal:  Pharm Biol       Date:  2020-12       Impact factor: 3.889

  9 in total

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