Literature DB >> 25329175

Synthesis aided structural determination of amyloid-β(1-15) glycopeptides, new biomarkers for Alzheimer's disease.

Peng Wang1, Jonas Nilsson, Gunnar Brinkmalm, Göran Larson, Xuefei Huang.   

Abstract

Unique tyrosine glycosylated amyloid-β(1-15) glycopeptides were synthesized with well-defined stereochemistry at the glycosidic linkages. Aided by these glycopeptides and tandem mass spectrometry analysis, the naturally existing amyloid-β glycopeptides, isolated from Alzheimer's disease patients, were determined to contain an α-linked N-acetyl galactosamine at the modified tyrosine 10 residue. Glycosylation can significantly impact the properties of amyloid-β as the glycopeptide has much lower affinity for Cu(+) ions.

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Year:  2014        PMID： 25329175      PMCID： PMC4221429          DOI： 10.1039/c4cc05085a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

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5.  Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.

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Journal:  Lancet Neurol       Date:  2014-06       Impact factor: 44.182

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Journal:  Nat Rev Neurol       Date:  2010-02-16       Impact factor: 42.937

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Journal:  J Am Chem Soc       Date:  2007-03-06       Impact factor: 15.419

Review 9.  Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.

Authors:  Peter Faller; Christelle Hureau; Olivia Berthoumieu
Journal:  Inorg Chem       Date:  2013-04-22       Impact factor: 5.165

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Journal:  ACS Chem Biol       Date:  2013-03-18       Impact factor: 5.100
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  7 in total

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Authors:  Jonas Nilsson
Journal:  Glycoconj J       Date:  2016-01-18       Impact factor: 2.916

2.  GalNAc-Tyrosine Is a Ligand of Plant Lectins, Antibodies, and Human and Murine Macrophage Galactose-Type Lectins.

Authors:  Ruslan Gibadullin; David Wayne Farnsworth; Joseph J Barchi; Jeffrey C Gildersleeve
Journal:  ACS Chem Biol       Date:  2017-07-14       Impact factor: 5.100

3.  Rapid phenolic O-glycosylation of small molecules and complex unprotected peptides in aqueous solvent.

Authors:  Tyler J Wadzinski; Angela Steinauer; Liana Hie; Guillaume Pelletier; Alanna Schepartz; Scott J Miller
Journal:  Nat Chem       Date:  2018-04-30       Impact factor: 24.427

4.  Enhanced Binding and Reduced Immunogenicity of Glycoconjugates Prepared via Solid-State Photoactivation of Aliphatic Diazirine Carbohydrates.

Authors:  Molly D Congdon; Jeffrey C Gildersleeve
Journal:  Bioconjug Chem       Date:  2020-12-16       Impact factor: 6.069

5.  Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer's disease patients.

Authors:  Jonas Nilsson; Gunnar Brinkmalm; Sherif Ramadan; Lisa Gilborne; Fredrik Noborn; Kaj Blennow; Anders Wallin; Johan Svensson; Mohamed A Abo-Riya; Xuefei Huang; Göran Larson
Journal:  Sci Rep       Date:  2019-04-02       Impact factor: 4.379

Review 6.  Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN, Langerin, MGL, and L-Sectin.

Authors:  Pablo Valverde; J Daniel Martínez; F Javier Cañada; Ana Ardá; Jesús Jiménez-Barbero
Journal:  Chembiochem       Date:  2020-07-02       Impact factor: 3.461

Review 7.  Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis.

Authors:  Stuart P Moon; Aaron T Balana; Matthew R Pratt
Journal:  Curr Opin Chem Biol       Date:  2021-06-25       Impact factor: 8.972
  7 in total

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