Implementation of pharmacists' interventions and assessment of medication errors in an intensive care unit of a Chinese tertiary hospital.

BACKGROUND: Pharmacist interventions and medication errors potentially differ between the People's Republic of China and other countries. This study aimed to report interventions administered by clinical pharmacists and analyze medication errors in an intensive care unit (ICU) in a tertiary hospital in People's Republic of China.
METHOD: A prospective, noncomparative, 6-month observational study was conducted in a general ICU of a tertiary hospital in the People's Republic of China. Clinical pharmacists performed interventions to prevent or resolve medication errors during daily rounds and documented all of these interventions and medication errors. Such interventions and medication errors were categorized and then analyzed.
RESULTS: During the 6-month observation period, a total of 489 pharmacist interventions were reported. Approximately 407 (83.2%) pharmacist interventions were accepted by ICU physicians. The incidence rate of medication errors was 124.7 per 1,000 patient-days. Improper drug frequency or dosing (n=152, 37.3%), drug omission (n=83, 20.4%), and potential or actual occurrence of adverse drug reaction (n=54, 13.3%) were the three most commonly committed medication errors. Approximately 339 (83.4%) medication errors did not pose any risks to the patients. Antimicrobials (n=171, 35.0%) were the most frequent type of medication associated with errors.
CONCLUSION: Medication errors during prescription frequently occurred in an ICU of a tertiary hospital in the People's Republic of China. Pharmacist interventions were also efficient in preventing medication errors.

Introduction

Medication errors (MEs) are among the most common preventable causes of adverse drug events.1,2 In 21 hospitals in the Netherlands, a retrospective study showed that >15% of adverse events were related to medications, and 21.2% of these events were considered preventable.3 In the Middle East, ME rates varied from 7.1% to 90.5% of prescription errors and from 9.4% to 80% of administration errors.4

Patients admitted in intensive care units (ICUs) are at a high risk of MEs because of critical illness, complex ICU environment, multiple medications, and frequent changes in medication therapy.5–8 Camiré et al9 reviewed data from 205 ICUs in 29 countries and found that the prevalence of MEs in ICUs was approximately 10.5 per 100 patient-days. Such a frequency of MEs was similar between prescription (54%) and administration (46%) phases. However, ME definitions and detection methods vary greatly in different reports.5

MEs may cause inefficient disease management for patients, additional workload for pharmacy personnel, increased cost for pharmacies and patients, frustration among patients and pharmacy staff, and increased patient morbidity and mortality.5,10 However, data regarding MEs in the People’s Republic of China remain limited; no information related to MEs in ICUs of Chinese tertiary hospitals has also been provided. In the United States, 62.2% of ICUs are equipped with clinical pharmacy services.11,12 The presence of clinical pharmacists in ICUs has reduced the number of adverse events, improved cost savings and medications, decreased mortality rates during ICU stay, and shortened the duration of ICU admission.13–15

In the People’s Republic of China, full-time clinical pharmacy services only began in 2005 after the People’s Republic of China Ministry of Health issued a series of documentations regarding clinical pharmacists. Given differences in cultures, laws, politics, clinical settings, and health care systems, the implementation of pharmacy services in ICU possibly varies between the People’s Republic of China and other countries. This study aimed to describe the development and implementation of full-time clinical pharmacy services in an ICU in People’s Republic of China. This study also aimed to evaluate MEs encountered in the ICU of a tertiary hospital in the People’s Republic of China. We also determined the parameters used to assess ME-related issues, such as prevalence rate, type, severity, and relevant medications.

Methods

Setting

The study was conducted in a general ICU of a university-affiliated tertiary hospital with 33 beds. The medical staff in the ICU comprised state-certified intensivists, ICU fellows and residents, registered nurses, respiratory therapists, a full-time critical care pharmacist, and two resident pharmacists.

Study design

A prospective, noncomparative, 6-month observational study was performed from January 1, 2013 to June 30, 2013. This study aimed to evaluate the interventions of clinical pharmacists and analyze the MEs encountered in the ICU of a tertiary hospital in the People’s Republic of China. All of the patients admitted to the ICU during the study period were included. If a patient was admitted and subsequently discharged without pharmacists’ participation, related medication orders were excluded in the calculation of results; no other exclusion criteria were applied. Ethical approval was acquired from the Research Review Committee of the hospital.

Pharmacist interventions

Pharmacy services were provided 8 hours a day, 5 days a week. Patient medication orders were reviewed by an experienced pharmacist and two pharmacist residents during daily clinical rounds and during pharmaceutical ward rounds. The monitored items included indications, contraindications, drug selection, drug-therapy duplication, drug dosage, drug administration, drug-treatment duration, potential drug–drug reactions, and adverse drug reaction (ADR)-related problems. Local evidence-based pharmacotherapy protocols and national and international pharmacotherapy guidelines were adopted for pharmacy reviewing.

With pharmacy services in the ICU, the interventions administered by the pharmacists were recorded in detail. For this purpose, the pharmacists completed a registration form for each intervention after they reviewed their medication orders, consulted with physicians, or administered other pharmacy services. The registration form completed by the pharmacists consists of the following items: specific date; patients’ baseline characteristics (sex, age, Acute Physiology and Chronic Health Evaluation II [APACHE II] score and diagnosis); length of ICU stay; number of drugs used in ICU; specific recommendations; medication details; to whom pharmaceutical activities were initiated; and whether the recommendations were accepted by the ICU physicians. All of the interventions were then evaluated in terms of intervention type, acceptance rate, and to whom pharmaceutical activities were initiated.

Assessment of MEs

Any error found in medication prescription, transcription, preparation, dispensation, and administration is defined as a ME.5 In this study, MEs referred to prescription errors; errors related to other processes were not evaluated. Each medication order detected with a potential ME was discussed by the ICU pharmacists with the attending ICU physicians. If the attending ICU physicians agreed with the pharmacists’ recommendations, then this medication order was changed and scored as an ME. If the attending ICU physicians did not accept the pharmacists’ recommendations, the detected potential ME was regarded as appropriate.14 The rate of >80% was considered well-accepted by the physicians in this study.

The prevalence rate, type, severity, and medications related to MEs were analyzed. The prevalence rate of MEs was expressed as the incidence rate of MEs per 1,000 monitored patient-days and calculated from the total number of MEs in ICU divided by the patients’ total length of ICU stay and multiplied by 1,000. The severity of MEs was evaluated according to the National Coordinating Council for Medication Error Reporting and Prevention (NCC-MERP) classification;14,16 this classification was divided into four categories according to the severity of the outcome: 1) MEs occurred without posing harm to patients (subcategories B and C); 2) MEs caused potential harm to patients (subcategory D); 3) MEs caused harm to patients (subcategories E, F, G, and H); and 4) MEs resulted in a patient’s death (subcategory I).

Data collection and analysis

Data collected were encoded by a pharmacist resident into Microsoft Excel 2007 (Microsoft Corporation, Redmond, WA, USA). Variables, including patients’ characteristics, type of recommendations, consensus rate, source of interventions, and ME-related concerns, such as prevalence rate, type and severity, and relevant medications, were analyzed.

Results

Patient characteristics

Patient characteristics are shown in Table 1. Among these patients, 403 (69.1%) were male; furthermore, 153 (26.2%) suffered from renal insufficiency with an estimated creatinine clearance of ≤50 mL/min upon admission or during ICU stay. A total of 99 (17.0%) were treated with renal replacement therapy (RRT) because of renal failure or acute kidney injury. The most frequently diagnosed illnesses in ICU admission were pneumonia and/or adult respiratory distress syndrome (n=137, 23.5%) followed by congestive heart failure/pulmonary edema (n=83, 14.2%).

Table 1

Patient characteristic during observational period in an ICU of a Chinese tertiary hospital

Characteristics	n (%)
n	583 (100)
Male	403 (69.1)
Female	180 (30.9)
Age (years)	60.7±21.9
Weight (kg)	62.4±25.8
APACHE II score	14.8±8.9
Patients with renal insufficiency*	153 (26.2)
Patients receiving renal replacement therapy	99 (17.0)
Admission diagnosis n (%)
Pneumonia and/or ARDS	137 (23.5)
CHF/pulmonary edema	83 (14.2)
Cerebrovascular accident	73 (12.5)
Cardiac/aortic surgery	65 (11.1)
Septic shock	51 (8.7)
Gastrointestinal surgery	43 (7.4)
MODS	28 (4.8)
Others	103 (17.7)
Length of ICU stay (d)	5.6±4.5
Drugs used per admission	6.5±4.6

Notes: Data are expressed as n (%) or mean ± standard deviation.

Patients with renal insufficiency were defined as patients older than 18 years and who had an estimated creatinine clearance less than or equal to 50 mL/min upon admission or during the ICU stay. “Others” includes trauma, severe pancreatitis, hyperkalemia, and hypercalcemia.

Abbreviations: APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, adult respiratory distress syndrome; CHF, congestive heart failure; ICU, intensive care unit; MODS, multiple organ dysfunction syndrome.

Implementation of pharmacist interventions

The pharmacists presented 489 recommendations to patients in the ICU during the observation period. Changes in drug frequency or dosage were the most frequent type of recommendations (n=178, 36.4%); among these changes, the majority (133 of 178, 74.7%) included dosage adjustment for patients with renal insufficiency or those subjected to RRT (Table 2).

Table 2

Type and number of pharmacist’s recommendations in an intensive care unit of a Chinese tertiary hospital

Category of pharmacist recommendations	n (%) recommendations	n (%) recommendations accepted
Change in drug frequency or dosing: improper drug frequency or dosing	178 (36.4)	149 (83.7)
Start new drugs: lack of use of needed drugs	81 (16.6)	72 (88.9)
Change or stop drugs: potential ADR or occurrence of ADR	69 (14.1)	54 (78.3)
Provision of drug information: lack of drug-related information	49 (10.0)	49 (100)
Change or stop drugs: improper drug selection or indication	41 (8.4)	21 (51.2)
Change or stop drugs: improper duration of drug treatment	27 (5.5)	22 (81.5)
Change or stop drugs: drug–drug interactions	18 (3.7)	16 (88.9)
Stop drugs: contraindication	11 (2.3)	11 (100)
Others: wrong solvent, duplication, etc.	15 (3.1)	13 (86.7)
Total	489 (100)	407 (83.2)

Abbreviation: ADR, adverse drug reaction.

Among 489 pharmacists’ recommendations, 338 (69.1%) were proactive; that is, these recommendations were initiated by the pharmacists, and 151 (30.9%) were initiated by medical/nursing staff when the pharmacists were in the ward or contacted via email/phone. Approximately 407 (83.2%) of the pharmacists’ recommendations could be accepted by the physicians (Table 2). Thus, 407 MEs were possibly prevented because of pharmacist intervention. The acceptance rate among the types of recommendations was ≥70%. The acceptance rate of the recommendations of wrong drug selection or indication was lower (51.2%) than that of other types of recommendations. The recommendations related to the provision of drug information or the discontinued use of drugs because of contraindication could be 100% accepted by the physicians.

Accordingly, 407 MEs were prevented by pharmacist interventions during the observation period. As a result, the incidence rate of MEs was approximately 124.7 per 1,000 monitored patient-days. Improper drug frequency or dosing (n=152, 37.3%), drug omission (n=83, 20.4%), and potential or actual occurrence of ADR (n=54, 13.3%) were the three most common MEs (Figure 1). Patients with renal insufficiency experienced MEs at a rate 2.3-times greater than those with normal renal function. The severity of MEs was further evaluated by NCC-MERP classification. As a result, 339 (83.4%) MEs posed no harm (subcategories B and C) to the patients, 48 (12.0%) were potentially harmful (subcategory D) to the patients, and 14 (3.4%) could actually harm the patients (preventable adverse drug event, subcategories E and F).

Figure 1

Type of medication errors encountered in an intensive care unit of a Chinese tertiary hospital.

Note: “Others” refer to medication errors, including wrong solvent, duplicated drug use, and so on.

Abbreviation: ADR, adverse drug reaction.

More than eight types of medications could cause MEs (Figure 2). Antimicrobials were the most frequent type of MEs (n=171, 35.0%) followed by cardiovascular drugs (n=76, 15.5%) and enteral/parenteral nutrition drugs (n=62, 12.7%). Considering specific drugs, we noted piperacillin/sulbactam (n=48, 9.8%), enteral nutrition drugs (n=76, 15.5%), and meropenem or imipenem (n=36, 7.4%) as drugs most commonly associated with MEs.

Figure 2

Type of medication with medication errors in an intensive care unit of a Chinese tertiary hospital.

Note: “Others” refer to corticosteroids, antidiabetics, electrolytes, hepatinica, and central nervous system drugs.

Abbreviation: GI, gastrointestinal.

Discussion

Cultures, laws, politics, clinical settings, and health care systems differ between the People’s Republic of China and other countries, such as the US or the UK. Moreover, the participation of pharmacists in ICU teams in the People’s Republic of China has been recently established. However, reports on the analysis of pharmacist interventions and the measurement of MEs in ICUs in the People’s Republic of China remain limited. To our knowledge, this study is the first to investigate pharmacist interventions and assess MEs in an ICU of a hospital in the People’s Republic of China. This study provided insights into the value of pharmacy services in the People’s Republic of China’s health care system.

A high number of recommendations accepted by the physicians indicated that pharmacists in ICUs were well accepted by physicians. However, acceptance rate was greatly dependent on the type of recommendations. Extremely important recommendations (drug contraindication) or urgent need for physicians (consulting regarding drug information) could reach a high acceptance rate (100%); by contrast, recommendations requiring specific clinical skills from pharmacists (drug selection) presented a low acceptance rate (51.2%). Despite remarkable improvements in pharmacy services in hospitals in the People’s Republic of China, clinical skills of clinical pharmacists are essential for pharmaceutical care in a patient-centered pharmacy setting. Therefore, this area should be further improved.

In this study, the incidence rate of MEs was approximately 124.7 per 1,000 monitored patient-days. This finding is close to that described by Camiré et al in which 29 countries with 205 ICUs are included.9 However, the prevalence rate of MEs in ICUs reported from different countries considerably varies. The following prevalence rates have been recorded: 276 per 1,000 patient-days in two ICUs in Northeastern USA;17 62.5–190.5 per 1,000 monitored patient-days in a Dutch ICU;14 and 65.1 per 1,000 patient-days in two pediatric ICUs in two tertiary-care teaching hospitals in Japan.18 These results could possibly be attributed to the differences in the ICUs of hospitals in different countries, as well as the type of ICUs, definitions of MEs, methods used to detect MEs, and other human factors (including stress, high workload, and knowledge deficits).19,20

The three most common MEs were improper drug frequency or dosage, drug omission, and potential or actual occurrence of ADR. Agalu19 reported that incorrect drug combination, drug omission, and wrong frequency are the three most common MEs in ICUs. By contrast, our findings are slightly similar to those of Klopotowska,14 in which the majority of MEs are related to drug- or dose-omission errors. Approximately 26.2% of patients in our department suffered from renal insufficiency and 16.7% of these patients received RRT. Dosage adjustment was frequently required for these patients when prescribed drugs were cleared in the renal system. The pharmacological knowledge of health care providers is an independent predictor of MEs.21 Although physicians are skilled in diagnosing diseases, they may be unfamiliar with the pharmacokinetics of prescribed medications. This condition is particularly true for younger physicians, such as physician residents and fellows, who are possibly at a high risk of committing dosage errors. The involvement of a pharmacist at the bedside with a medical team may help physicians understand the prescribed medications.

Antimicrobials, cardiovascular drugs, and enteral/parenteral nutrition, which are frequently prescribed or changed by ICU physicians, are at a higher risk of MEs than other medications. These findings are similar to those of Agalu et al, and Klopotowska et al, in which antibiotics are the most common drugs subjected to prescription errors.14,19 This result is possibly because antibiotics are the most-frequently prescribed and/or changed drugs in ICUs. However, the results from an ICU in Pennsylvania, USA were quite different; in particular, opioid analgesics, beta-lactam antimicrobials, and blood coagulation modifiers were the three most common drugs associated with MEs in the Pennsylvania study.22 This difference may be due to different types of patients in various ICUs.

Many strategies have been proposed to prevent MEs. These include optimizing medication processes, eliminating situational risk factors, adequate staffing, and promoting pharmacist participation in ICU care.5 The influence of clinical pharmacists in ICUs has reduced the number of adverse effects, decreased mortality rates during ICU stay, improved medication dosage and cost savings, and shortened the duration of ICU stay.13–15 Whether a pharmacist providing critical care based on the Chinese health care system reduces adverse drug events, enhances cost savings, or provides other values will be investigated in our future studies.

Therefore, this study demonstrated that the presence of pharmacists in the ICU was well-accepted by medical teams in the People’s Republic of China. A total of 407 MEs were possibly prevented by pharmacist interventions. The incidence rate of MEs was approximately 124.7 per 1,000 patient-days. The assessment of MEs revealed that improper drug frequency or dosage, drug omission, and potential or actual occurrence of ADR were the three most common types of MEs, and 83.4% of MEs did not pose any risk to patients. Antimicrobials were most commonly associated with MEs. These results will help understand MEs commonly encountered in an ICU in the People’s Republic of China and enhance our pharmacy services in the future.