Is hypoalbuminemia a prognostic risk factor for contrast-induced nephropathy in peritoneal dialysis patients?

OBJECTIVE: Residual renal function (RRF) is an important predictor of outcome in peritoneal dialysis (PD) patients. Hypoalbuminemia was found to be an independent risk factor for the development of acute kidney injury. We investigated the possibility of an association between serum albumin levels and the development of iodine contrast media-induced nephropathy (CIN) in PD patients.
METHODS: A total of 103 PD patients who underwent invasive angiographies with exposure to iodine contrast media (ICM) were reviewed retrospectively. All patients received 0.9% saline intravenously at a rate of 75 mL per hour for 12 hours prior, during, and 12 hours after exposure to ICM. Acetylcysteine was given orally at a dose of 600 mg twice daily, on the day before and on the day of exposure to ICM. The nonionic, low-osmolar contrast agent iopromide was used at a mean dose of 75.0±15.2 mL. The changes in RRF from baseline to 1 week and 4 weeks after exposure to ICM were recorded. Outcomes of patients with serum albumin levels <3.8 g/dL and those with serum albumin levels ≥3.8 g/dL were compared. A reduction >30% in RRF at 7 days after exposure to ICM was considered CIN.
RESULTS: CIN developed in 27.2% (28/103) of patients. Of the 103 patients, 59.2% (61) had serum albumin levels <3.8 g/dL. Of those, 37.7% (23/61) developed CIN, compared with 11.9% (5/42) of those with serum albumin levels ≥3.8 g/dL (P=0.004). After adjustment for all tested variables in a logistic regression with a stepwise selection model, serum albumin level at exposure to ICM was found to be the most powerful predictor of the development of CIN (odds ratio =4.5; confidence interval =1.5-13.0; P=0.006).
CONCLUSION: PD patients with serum albumin levels <3.8 g/dL should be monitored carefully when exposed to ICM. Serum albumin level may be considered a potential therapeutic target in the prevention of CIN and preservation of RRF in PD patients.

Introduction

Residual renal function (RRF) is conserved and persists longer in peritoneal dialysis (PD) than in hemodialysis (HD) patients.1 The preservation of RRF contributes to decreased morbidity and mortality in PD patients and may be particularly important for the effectiveness of long-term PD.2,3

Diabetes, congestive heart failure, peritonitis, and proteinuria are among the factors associated with an accelerated decline in RRF in PD patients.4,5 Associations between RRF and patient sex, age, and PD modality, are inconclusive.6 Loop diuretics have been shown not to affect the evolution of RRF.7 Angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), and calcium-channel blockers (CCB) have been associated with a decreased risk of RRF decline.8,9

For the general population receiving iodine contrast media (ICM), acute kidney injury has been reported in 3%–14%.10–12 The main risk factors that have been identified for contrast media-induced nephropathy (CIN) in this population are older age, the presence of diabetic nephropathy, volume depletion, cardiac failure, liver failure, and preexisting chronic kidney disease (CKD).10 In such cases of iodine CIN, an increase in serum creatinine concentration begins on day 2, reaches a maximum between days 4 and 7, and then decreases between days 7 and 21.10 CIN is a multifactorial disorder with a pathogenesis that remains unclear. Reduction in renal perfusion caused by a direct effect of contrast-agent administration on the kidneys and its toxic effect on the tubular cells are usually considered the major pathophysiological factors that contribute to the development of CIN.13–16

The data are sparse regarding the potentially adverse effects of ICM administration on RRF in PD patients.6,10 Although the authors of one study were unable to identify any changes in RRF following ICM administration in PD patients, other investigators concluded that the use of ICM in this population should be counterbalanced against a critical evaluation of the risk–benefit ratio.3,4 Assessment of risk for CIN in PD patients is usually based on the findings of a few studies and on extrapolation of results from CKD patients.6 Hypoalbuminemia has been found to be an independent risk factor for the development of acute kidney injury in elderly patients, those with rhabdomyolysis, after surgery for gastric cancer, and after coronary artery bypass surgery.17–20 We are unaware of any studies that have investigated the impact of serum albumin levels on the development of CIN in PD patients. Since changes in serum creatinine levels are less sensitive in detecting small changes in RRF in dialysis patients when exposed to ICM, we set out to determine the changes in RRF from baseline to 1 week and 4 weeks after exposure to ICM in 103 stable PD patients, by using 24-hour urine collection, and to compare the outcomes between patients with serum albumin levels <3.8 g/dL and those with levels ≥3.8 g/dL.

Patients and methods

A total of 114 PD patients who underwent invasive angiographies with exposure to ICM between January 2000 and December 2013 were reviewed retrospectively. All patients received 0.9% saline intravenously at a rate of 75 mL per hour for 12 hours prior, during, and 12 hours after exposure to ICM in order to ensure adequate clinical hydration. Acetylcysteine was given orally at a dose of 600 mg twice on the day before and twice on the day of exposure to ICM. PD was continued during exposure to ICM. The nonionic, low-osmolar contrast agent iopromide (Schering, Berlin, Germany) was used with a mean dose of 75.0±15.2 mL. RRF was assessed as the average of 24-hour urinary urea and creatinine clearance and expressed as mL/min/1.73 m2.

In accordance with our aim to preserve RRF as much as possible, it is the policy in our PD unit to routinely assess RRF at 3-month intervals. For the majority of patients receiving planned administration of ICM, RRF is routinely assessed before exposure to ICM and at 1 week and 4 weeks thereafter, in order to detect any changes in the RRF that may necessitate modifications to the PD regimen and adjustment of the diuretic dosage. A reduction of >30% in RRF at 7 days after exposure to ICM is considered CIN.

For some patients during the study period who needed urgent ICM administration, assessment of RRF was not performed before exposure to ICM, and patients did not receive acetylcysteine on the day before exposure to ICM; however, RRF was routinely assessed at 1 week and 4 weeks after exposure to ICM in order to detect changes in the RRF, as well as to adjust the PD regimen and diuretic dosage. These patients are not included in the present study.

The 24-hour urine collection is not a routine test during acute kidney injury. However, since all patients in this study were on maintenance PD due to end-stage renal disease, their serum creatinine levels were relatively high; changes in serum creatinine may be less sensitive, as might be the estimated glomerular filtration rate. Moreover, due to the retrospective design of the study, we were able to use the data that were available in the medical records. Therefore, we set out to determine the changes in RRF from baseline to 1 week and 4 weeks after the exposure to ICM. In previous studies, 24-hour urine collection was used to assess RRF during acute kidney injury. For example, Moranne et al prospectively evaluated the effect of iodinated contrast agents on RRF in PD patients, 24 hours before and 2 weeks after exposure to ICM.21 In that study, as in the current one, RRF was quantified as the average of 24-hour urinary creatinine and urea clearance.

Eligibility criteria were: age above 18 years, follow-up period of ≥3 months before exposure to ICM, a 24-hour urine volume of >300 mL/day, and RRF >3 mL/min/1.73 m2. Exclusion criteria were: episodes of peritonitis in the 3-month period prior to the administration of ICM, and/or modifications in hypertensive medications or PD dialysis regimens or methods during the month preceding the exposure to ICM or between RRF assessments. Patients who needed urgent ICM administration were also excluded, because they did not receive acetylcysteine the day before the exposure to ICM, and the assessment of RRF was not performed before the exposure to ICM.

The following data were collected from patient medical records: age, sex, background illnesses, blood pressure, PD method (continuous ambulatory peritoneal dialysis [CAPD] or automated peritoneal dialysis [APD]), PD vintage, hemoglobin, plasma C-reactive protein, serum albumin and 24-hour proteinuria levels, 24-hour urine volume, RRF, medications (ACEIs, ARBs, CCB, and diuretics).

Serum albumin levels below 3.5 g/dL are generally considered low. However, according to the NKF K/DOQI guidelines 2,000, serum albumin levels equal to or greater than the lower limit of the normal range (approximately 4.0 g/dL for the bromocresol green method) is considered the outcome goal in patients on maintenance dialysis. In two previous studies, conducted by Kim et al and Lee et al serum albumin levels lower than 4.0 g/dL were used.19,20 In an observational cohort study of 130,052 dialysis patients (12,171 PD and 117,851 HD) undertaken to determine the survival predictability of serum albumin levels in PD patients and to compare them with those in HD patients, a serum albumin level of 4.0 g/dL was used for HD patients and a level of 3.8 g/dL for PD patients.22 In a study of 58,058 HD patients, a baseline serum albumin level <3.8 g/dL was used to estimate the risk of death in this population.23 Moreover, the criteria for diagnosis of protein–energy wasting in patients with end-stage renal disease proposed by a panel of experts from the International Society of Renal Nutrition and Metabolism include a serum albumin level (measured using the bromocresol green method) of <3.8 g/dL.24,25

In the planning of this study and before analyzing the data, we set the criteria for comparing the outcomes between patients with serum albumin <3.8 g/dL and those with levels ≥3.8 g/dL (measured using the bromocresol green method).

Statistical analysis

Statistical analysis was carried out using SPSS (v 19, IBM Corporation, Armonk, NY, USA) software. P<0.05 were considered to be significant. Continuous variables were reported as means and standard deviations, and categorical variables as frequencies and percentages. The chi-square test was used to evaluate and compare the frequencies between the study groups including PD modality, sex, medications, primary renal disease, and the presence of diabetes mellitus, hypertension, and plasma high-sensitivity C-reactive protein (hsCRP) levels >5 mg/dL. The independent t-test was used to evaluate and compare the differences between the study groups, including age, mean arterial pressure (MAP), PD vintage, Kt/v, hemoglobin and HbA1c levels, plasma hsCRP levels, 24-hour urine volume and proteinuria, and RRF. Paired t-tests were used to evaluate and compare changes in RRF between baseline and 1 week and 4 weeks after exposure to ICM in each of the study groups. Logistic regression was applied to identify variables that predict the development of CIN. A final model was constructed using clinical judgment and a stepwise selection method with predetermined significance.

Results

Of a total of 114 PD patients who underwent invasive angiographies with exposure to ICM, eleven patients were excluded. Of these, six received ICM for urgent reasons, two had modifications in their hypertensive medications, two had modifications in their dialysis regimen within the 4 weeks of the exposure to ICM, and one had peritonitis 1 month prior to exposure to ICM. Thus, 103 stable PD patients were included in the study.

Patients on CAPD received four exchanges of 2 L/day of glucose-based dialysis solutions (GBSs). Patients on APD received a 10–15 L/day GBS nightly regimen.

The serum range of patients with serum albumin levels <3.8 g/dL was 2.7–3.7 g/dL and the serum range of patients with serum albumin levels ≥3.8 g/dL was 3.8–4.5 g/dL. Serum albumin <3.8 g/dL was detected in 59.2% (61/103) of the patients (Figure 1). Of them, 37 (60.7%) were female, 27 (44.3%) had diabetes mellitus, 44 (72.1%) had hypertension, 35 (57.4%) were on CAPD, and 26 (42.6%) were on APD (Table 1). No statistically significant differences were found between patients with serum albumin <3.8 g/dL and those with levels ≥3.8 g/dL in terms of the primary kidney disease and baseline characteristics (Table 1).

Figure 1

The patient cohort according to serum albumin levels, the development of iodine contrast media-induced nephropathy (CIN), and the residual renal function (RRF) in peritoneal dialysis (PD) patients exposed to iodine contrast media (ICM).

Table 1

Baseline characteristics of peritoneal dialysis patients with serum albumin <3.8 g/dL and those with serum albumin ≥3.8 g/dL before the exposure to iodine contrast media

Variable	P-value	Serum albumin
		≥3.8 g/dL	<3.8 g/dL
Patients (n)		42	61
Age (years)	0.557**	58.4±10.2	57.1±11.1
CAPD, % (n)	0.828*	59.5 (25)	57.4 (35)
APD, % (n)	0.828*	40.5 (17)	42.6 (26)
Females, % (n)	0.551*	54.8 (23)	60.7 (37)
Diabetes mellitus, % (n)	0.888*	42.9 (18)	44.3 (27)
Hypertension, % (n)	0.735*	69.0 (29)	72.1 (44)
Loop diuretics, % (n)	–	100 (42)	100 (61)
ACEI/ARB, % (n)	0.971*	64.3 (27)	63.9 (39)
CCB, % (n)	0.959*	40.5 (17)	41.0 (25)
MAP, mmHg	0.634**	98.2±7.1	97.4±7.9
Vintage, months	0.820**	38.3±14.2	37.7±11.6
Kt/v	0.569**	2.0±0.3	2.1±0.4
Hemoglobin, g/dL	0.518**	11.5±1.5	11.3±1.6
Serum albumin, g/dL	<0.001	4.2±0.2	3.3±0.3
HbA1c, %	0.404**	6.5±0.9	6.7±1.0
Plasma hsCRP, mg/dL	0.704**	7.4±5.3	7.9±7.1
24-hour urine volume, mL	0.258**	623.8±155.9	671.3±266.5
24-hour proteinuria, g/day	0.395**	0.66±0.25	0.71±0.32
Baseline RRF, mL/min/1.73	0.740**	8.10±2.16	8.30±2.35
Primary renal disease, % (n)
Diabetic nephropathy	0.888**	42.9 (18)	44.3 (27)
Hypertension	0.954**	33.3 (14)	32.8 (20)
Glomerulopathy	1.000**	9.5 (4)	9.8 (6)
Chronic interstitial disease	1.000**	4.8 (2)	4.9 (3)
Unknown etiology	1.000**	9.5 (4)	8.2 (5)

Notes:

Chi-square test,

independent t-test. For serum albumin, values are represented mean ± standard deviation unless unless otherwise specified.

Abbreviations: ACEI, angiotensin-converting enzyme inhibitor; APD, automated peritoneal dialysis; ARB, angiotensin-receptor antagonist; CAPD, continuous ambulatory peritoneal dialysis; CCB, calcium-channel blocker; hsCRP, high-sensitivity C-reactive protein; MAP, mean arterial pressure; RRF, residual renal function; HbA1c, glycosylated haemoglobin level.

All patients received loop diuretics; 64.1% (66/103) were treated with ACEIs/ARBs and 40.8% (42/103) treated with CCB (Table 1).

At baseline, both study groups (patients with serum albumin <3.8 g/dL and patients with serum albumin ≥3.8 g/dL) were similar in terms of their age; the PD method they were on; sex; the presence of diabetes mellitus and hypertension; the use of diuretics; ACEIs/ARBs and CCBs; MAP; PD vintage; Kt/v; hemoglobin, HbA1c, and plasma hsCRP levels; 24-hour urine volume; 24-hour proteinuria; and RRF (Table 1).

CIN developed in 27.2% (28/103) of the patients in the cohort (Figure 1). The mean serum albumin levels of patients who developed CIN was lower than that of patients who did not develop CIN (3.3±0.5 g/dL and 3.8±0.5 g/dL, respectively; P<0.001) (Table 2). Of patients with serum albumin <3.8 g/dL, 23 (37.7%) developed CIN compared with 11.9% (5/42) of those with serum albumin ≥3.8 g/dL (P=0.004) (Figure 1, Table 3).

Table 2

Characteristics of patients who developed contrast-induced nephropathy (CIN) compared with those who did not develop CIN after exposure to iodine contrast media

Variable	P-value	CIN- (n=75)	CIN+ (n=28)
Age, years	0.874**	57.7±11.1	57.4±9.6
CAPD, % (n)	0.757*	57.3 (43)	60.7 (17)
APD, % (n)	0.757*	42.7 (32)	39.3 (11)
Female, % (n)	0.448*	56.0 (42)	64.3 (18)
Diabetes mellitus, % (n)	0.093*	38.7 (29)	57.1 (16)
Hypertension, % (n)	0.940*	70.7 (53)	71.4 (20)
Loop diuretics, % (n)	–	100 (75)	100 (28)
ACEI/ARB, % (n)	0.979*	64.0 (48)	64.3 (18)
CCB, % (n)	0.851*	41.3 (31)	39.3 (11)
MAP, mmHg	0.256**	97.2±7.5	99.1±7.5
Vintage, months	0.004**	35.8±12.1	43.7±12.6
Kt/v	0.545**	2.1±0.4	2.0±0.3
Hemoglobin, g/dL	0.968**	11.4±1.6	11.4±1.5
HbA1c, %	0.407**	6.6±0.9	6.8±1.0
Plasma hsCRP, mg/dL	0.668**	7.5±6.4	8.1±6.6
Plasma hsCRP >5 mg/dL, % (n)	0.078*	56 (42)	75 (21)
Dose of contrast agent, mL	0.878**	75.8±17.2	74.3±16.7
24-hour urine volume, mL	0.851**	649.3±232.6	658.9±220.3
24-hour proteinuria, g/day	0.712**	0.7±0.3	0.67±0.2
Serum albumin, g/dL	<0.001**	3.8±0.5	3.3±0.5
Baseline RRF, mL/min/1.73	0.530**	8.15±2.26	8.46±2.30

Notes:

Chi-square test,

independent t-test. Values are represented mean ± standard deviation unless unless otherwise specified.

Abbreviations: ACEI, angiotensin-converting enzyme inhibitor; APD, automated peritoneal dialysis; ARB, angiotensin-receptor antagonist; CAPD, continuous ambulatory peritoneal dialysis; CCB, calcium-channel blocker; hsCRP, high-sensitivity C-reactive protein; MAP, mean arterial pressure; RRF, residual renal function; HbA1c, glycosylated haemoglobin level.

Table 3

Contrast-induced nephropathy (CIN) within 7 days of exposure to iodine contrast media in peritoneal dialysis patients with serum albumin <3.8 g/dL and those with serum albumin ≥3.8 g/dL

Serum albumin	CIN+, n (%)	CIN-, n (%)	P-value
<3.8 g/dL	23/61 (37.7%)	38/61 (62.3%)	0.004*
≥3.8 g/dL	5/42 (11.9%)	37/42 (88.1%)	0.004*

Note:

Chi-square test.

In patients who developed CIN, PD vintage was higher than in patients who did not develop CIN (P=0.004) (Table 2). Patients who developed CIN had a higher proportion of diabetes mellitus and higher plasma hsCRP levels than those who did not develop CIN, but these differences were not statistically significant (Table 2). No statistically significant differences were found between patients who developed CIN and those who did not develop CIN in terms of age; PD method; sex; use of diuretics, ACEIs, ARBs, or CCBs; Kt/v; blood pressure; hemoglobin, HbA1c, and plasma hsCRP levels; 24-hour urine volume; levels of 24-hour proteinuria; and baseline RRF (Table 2). In comparing the subgroups of patients with serum albumin <3.8 g/dL who developed CIN with patients with serum albumin <3.8 g/dL who did not develop CIN, serum albumin levels were lower in those who developed CIN (P=0.002) and PD vintage was higher (P=0.047) (Table 4).

Table 4

Characteristics of patients with serum albumin <3.8 g/dL who developed contrast-induced nephropathy (CIN) compared with those with serum albumin <3.8 g/dL who did not develop CIN after exposure to iodine contrast media

Variable	P-value	CIN- (n=38)	CIN+ (n=23)
Age, years	0.894**	57.3±11.7	56.9±10.2
CAPD, % (n)	0.668*	55.3 (21)	60.9 (14)
APD, % (n)	0.668*	44.7 (17)	39.1 (9)
Female, % (n)	0.570*	57.9 (22)	65.2 (15)
Diabetes mellitus, % (n)	0.134*	36.8 (14)	56.5 (13)
Hypertension, % (n)	0.809*	71.1 (27)	73.9 (17)
Loop diuretics, % (n)	–	100 (38)	100.0 (23)
ACEI/ARB, % (n)	0.871*	63.2 (24)	65.2 (15)
CCB, % (n)	0.819*	42.1 (16)	39.1 (9)
MAP, mmHg	0.166**	96.3±7.7	99.2±8.0
Vintage, months	0.047**	35.4±11.8	41.5±10.3
Kt/v	0.552**	2.1±0.4	2.0±0.3
Hemoglobin, g/dL	0.731**	11.2±1.7	11.4±1.5
HbA1c, %	0.677**	6.6±1.0	6.8±1.0
Plasma hsCRP, mg/dL	0.750**	7.7±7.1	8.3±7.2
Plasma hsCRP >5 mg/dL, % (n)	0.134*	50.0 (19)	69.6 (16)
24-hour urine volume, mL	0.992**	671.0±292.6	671.7±223.0
24-hour proteinuria, g/day	0.391**	0.74±0.35	0.67±0.26
Serum albumin, g/dL	0.002**	3.4±0.3	3.1±0.3
Baseline RRF, mL/min/1.73	0.490**	8.13±2.38	8.57±2.33

Notes:

Chi-square test,

independent t-test. Values are represented mean ± standard deviation unless unless otherwise specified.

Abbreviations: ACEI, angiotensin-converting enzyme inhibitor; APD, automated peritoneal dialysis; ARB, angiotensin-receptor antagonist; CAPD, continuous ambulatory peritoneal dialysis; CCB, calcium-channel blocker; hsCRP, high-sensitivity C-reactive protein; MAP, mean arterial pressure; RRF, residual renal function; HbA1c, glycosylated haemoglobin level.

Of the patients who developed CIN, RRF was recovered in 80% (4/5) of those with serum albumin ≥3.8 g/dL and in 34.8% (8/23) of those with serum albumin <3.8 g/dL (Figure 1). Baseline RRF was similar in patients with serum albumin <3.8 g/dL and those with serum albumin ≥3.8 g/dL (Figures 2 and 3). In comparing RRF before the exposure to ICM, and at 1 week and 4 weeks thereafter, among patients with serum albumin ≥3.8 g/dL, no significant variation in RRF was observed (Figure 2). In contrast, in patients with serum albumin <3.8 g/dL, a significant reduction was observed in RRF at 1 week after exposure to ICM; at 4 weeks, a significant but only partial improvement was observed in RRF (Figure 2).

Figure 2

Evolution of residual renal function (RRF) from baseline levels to 1 week and 4 weeks after exposure to iodine contrast media (ICM) in peritoneal dialysis patients with serum albumin <3.8 g/dL and those with serum albumin ≥3.8 g/dL (paired t-test).

After adjustment for all tested variables in a logistic regression with a stepwise selection model, serum albumin level at exposure to ICM was found to be the most powerful predictor of the development of CIN (odds ratio =4.5; confidence interval =1.5–13.0, P=0.006).

Discussion

The main finding of this study is the significantly lower mean level of serum albumin among patients undergoing PD who developed CIN than among those who did not develop CIN. Hypoalbuminemia in PD patients can be multifactorial and might reflect increased systemic inflammation, volume overload, ongoing peritoneal and urinary losses of protein, and impaired compensatory hepatic synthesis of albumin. The retrospective study design did not enable evaluation of the reasons for hypoalbuminemia.

The incidence of CIN has been increasing in recent years, as a result of the widespread use of contrast media in diagnostic and treatment practices, and developments in angiographic techniques. Risk assessment for CIN in PD patients is currently based on sparse data from a few studies, and on extrapolation of findings from CKD patients.6 To the best of our knowledge, the impact of serum albumin levels on the development of CIN in PD patients has not been studied. The results of the present study reveal that a substantial proportion of PD patients had serum albumin <3.8 g/dL. Similarly, in an observational cohort study of 130,052 dialysis patients (12,171 PD and 117,851 HD), 63% of PD patients had serum albumin <3.8 g/dL.22 In the current study, CIN developed in 27.2% of all studied PD patients compared with in 3%–14% of the general population.10–12 Furthermore, three times as many patients with serum albumin <3.8 g/dL developed CIN as did patients with serum albumin ≥3.8 g/dL (Figure 1, Table 3).

Two mechanisms have been proposed to explain the occurrence of CIN. Renal blood flow decreases by 30% to 45% within 2 to 4 hours of ICM injection, leading to the development of renal hypoxia.13–16 In patients with advanced CKD, RRF remarkably depends on the single nephron glomerular filtration rate, which, in itself, is particularly dependent on renal blood flow. If the renal blood flow decreases, as happens when ICM is administered, the RRF may subsequently decrease. A second possible mechanism for the occurrence of CIN is that free radicals resulting from contrast-agent injection induce cytotoxic effects, which cause renal tubule damage.13–16

Moreover, serum albumin is the most abundant serum protein and responsible for 70% of the total osmotic pressure.26 Among its various vital functions in the body, serum albumin maintains the oncotic pressure in the vascular system and has antioxidant properties.27 Some studies have reported a preventive role of serum albumin for CIN through vascular expansion and its antioxidant properties.28 The mechanism involved in the association between nephropathy and low albumin is not fully understood; however, low albumin is likely to be responsible for the development of CIN by causing renal tubular cytotoxic damage with free radicals.

One study reported that N-acetylcysteine may improve RRF in patients treated with PD.29 On the other hand, low serum albumin has been identified as a risk factor for developing CIN in patients without CKD who underwent bronchial arteriography or embolization.30 One prospective study showed no accelerated decline in RRF over the 2-week period following ICM exposure in 36 stable PD patients with adequate prehydration.21 Another prospective study reported that administration of ICM did not lead to a persistent decline of RRF in ten CAPD patients who received elective diagnostic intravenous or intra-arterial administration of ICM.31 A retrospective analysis did not show that administration of ICM has a long-term effect on RRF in dialysis patients.32 These studies were small and did not consider in their analyses the effect of serum albumin levels on the development of CIN. All patients exposed to ICM in the present study received adequate hydration and N-acetylcysteine. Nonetheless, most of the CIN cases occurred among hypoalbuminemic patients with serum albumin levels <3.8 g/dL. The low levels of serum albumin thus seem to contribute to the development of CIN, but the mechanisms of its involvement need elucidation.

PD vintage was greater in patients who developed CIN compared with those who did not. The possibility that PD vintage may be a risk factor for CIN is an area for future investigation. Rates of diabetes mellitus and plasma hsCRP levels >5 mg/dL were higher, though without statistical significance, among patients who developed CIN, suggesting that associations between these factors and the development of CIN should be investigated further.

Although baseline RRF was similar in patients with serum albumin <3.8 g/dL and those with serum albumin ≥3.8 g/dL, the rate of recovery from CIN after 4 weeks was considerably higher among those with higher albumin levels (80% vs 34.8%) (Figure 2). Further, among patients with serum albumin <3.8 g/dL, mean RRF decreased significantly at 1 week after the exposure to ICM and was notably, but incompletely, improved at 4 weeks, contrasting with the absence of a significant variation in RRF among those with higher albumin levels (Figure 2).

Serum albumin level at exposure to ICM was the most powerful predictor of the development of CIN (odds ratio =4.5; confidence interval =1.5–13.0; P=0.006). The contribution of low serum albumin levels (<3.8 g/dL) to the development of CIN shown herein raises the possibility that the simple measure of serum albumin may represent a potential therapeutic target in the prevention of CIN and preservation of RRF when PD patients are exposed to intravenous or intra-arterial ICM.

Limitations

The present study is retrospective. From the presented data, no conclusions can be drawn about possible long-term effects (beyond 4 weeks) of intravenous injection of ICM. However, it seems that patients who recover their RRF within 4 weeks may maintain their RRF more than those whose RRF does not recover. Furthermore, we cannot draw conclusions about the long-term effects (beyond 4 weeks) in patients who did not recover. However, the findings may provide useful information for future multicenter prospective studies aimed at investigating the prevalence rate, risk factors, and long-term effects of CIN in PD patients.

In addition, the retrospective design of this study did not enable the evaluation of the reasons for hypoalbuminemia.

Conclusion

PD patients with serum albumin levels <3.8 g/dL should be monitored carefully when exposed to ICM. Serum albumin levels may be considered a potential therapeutic target in the prevention of CIN and preservation of RRF in PD patients.