INTRODUCTION: Up to 18% of people in industrialised societies are mildly affected by chronic tinnitus, and 0.5% report tinnitus having a severe effect on their daily life. Tinnitus can be associated with hearing loss, acoustic neuromas, drug toxicity, ear diseases, and depression. Tinnitus can last for many years, and can interfere with sleep and concentration. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for chronic tinnitus? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 33 studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review, we present information relating to the effectiveness and safety of the following interventions: acamprosate, acupuncture, antidepressant drugs, benzodiazepines, carbamazepine, electromagnetic stimulation, ginkgo biloba, hearing aids, hypnosis, psychotherapy, tinnitus-masking devices, and cognitive behavioural therapy plus tinnitus-masking device (tinnitus retraining therapy).
INTRODUCTION: Up to 18% of people in industrialised societies are mildly affected by chronic tinnitus, and 0.5% report tinnitus having a severe effect on their daily life. Tinnitus can be associated with hearing loss, acoustic neuromas, drug toxicity, ear diseases, and depression. Tinnitus can last for many years, and can interfere with sleep and concentration. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for chronic tinnitus? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 33 studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review, we present information relating to the effectiveness and safety of the following interventions: acamprosate, acupuncture, antidepressant drugs, benzodiazepines, carbamazepine, electromagnetic stimulation, ginkgo biloba, hearing aids, hypnosis, psychotherapy, tinnitus-masking devices, and cognitive behavioural therapy plus tinnitus-masking device (tinnitus retraining therapy).
Authors: Rilana F F Cima; Iris H Maes; Manuela A Joore; Dyon J W M Scheyen; Amr El Refaie; David M Baguley; Lucien J C Anteunis; Gerard J P van Breukelen; Johan W S Vlaeyen Journal: Lancet Date: 2012-05-26 Impact factor: 79.321
Authors: Minke J C van den Berge; Rolien H Free; Rosemarie Arnold; Emile de Kleine; Rutger Hofman; J Marc C van Dijk; Pim van Dijk Journal: Front Neurol Date: 2017-04-03 Impact factor: 4.003
Authors: Massimo Ralli; Vittorio D'Aguanno; Arianna Di Stadio; Armando De Virgilio; Adelchi Croce; Lucia Longo; Antonio Greco; Marco de Vincentiis Journal: J Immunol Res Date: 2018-08-19 Impact factor: 4.818
Authors: Minke J C van den Berge; J M C van Dijk; Jan D M Metzemaekers; Bert Maat; Rolien H Free; Pim van Dijk Journal: BMJ Open Date: 2019-06-14 Impact factor: 2.692
Authors: Maria Fernanda Capoani Garcia Mondelli; Aline Faure Cabreira; Izabella Lima de Matos; Maria Carolina Ferreira; Andressa Vital Rocha Journal: Int Arch Otorhinolaryngol Date: 2020-06-23
Authors: Stefan Schoisswohl; Berthold Langguth; Martin Schecklmann; Alberto Bernal-Robledano; Benjamin Boecking; Christopher R Cederroth; Dimitra Chalanouli; Rilana Cima; Sam Denys; Juliane Dettling-Papargyris; Alba Escalera-Balsera; Juan Manuel Espinosa-Sanchez; Alvaro Gallego-Martinez; Efi Giannopoulou; Leyre Hidalgo-Lopez; Michael Hummel; Dimitris Kikidis; Michael Koller; Jose A Lopez-Escamez; Steven C Marcrum; Nikolaos Markatos; Juan Martin-Lagos; Maria Martinez-Martinez; Marta Martinez-Martinez; Maria Mata Ferron; Birgit Mazurek; Nicolas Mueller-Locatelli; Patrick Neff; Kevin Oppel; Patricia Perez-Carpena; Paula Robles-Bolivar; Matthias Rose; Tabea Schiele; Axel Schiller; Jorge Simoes; Sabine Stark; Susanne Staudinger; Alexandra Stege; Nicolas Verhaert; Winfried Schlee Journal: Trials Date: 2021-12-04 Impact factor: 2.279