Literature DB >> 25327953

Insulin regulation of myocardial autophagy.

Christian Riehle1, E Dale Abel.   

Abstract

Autophagy is a conserved cellular process that plays an important role in cardiovascular homeostasis. Basal levels of autophagy are required for the maintenance of organellar quality control. Autophagy is dynamically regulated in the heart in the fasting to re-feeding transition. Insulin signaling plays an important role in the regulation of myocardial fuel metabolism, mitochondrial function and cellular growth. Recent studies have suggested an important role for insulin signaling in the regulation of myocardial autophagy. This dynamic regulation of autophagy induction during fasting may contribute to organellar homeostasis and if perturbed under conditions of hyperinsulinemia could contribute to accelerated cardiac aging.

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Year:  2014        PMID： 25327953      PMCID： PMC5609463          DOI： 10.1253/circj.cj-14-1080

Source DB:  PubMed          Journal:  Circ J        ISSN： 1346-9843            Impact factor:   2.993


  73 in total

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Journal:  Circ Res       Date:  2013-08-30       Impact factor: 17.367

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Journal:  J Mol Cell Cardiol       Date:  2012-02-09       Impact factor: 5.000

3.  Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density.

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Journal:  J Mol Cell Cardiol       Date:  2005-10-10       Impact factor: 5.000

4.  Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

Authors:  Sihem Boudina; Heiko Bugger; Sandra Sena; Brian T O'Neill; Vlad G Zaha; Olesya Ilkun; Jordan J Wright; Pradip K Mazumder; Eric Palfreyman; Timothy J Tidwell; Heather Theobald; Oleh Khalimonchuk; Benjamin Wayment; Xiaoming Sheng; Kenneth J Rodnick; Ryan Centini; Dong Chen; Sheldon E Litwin; Bart E Weimer; E Dale Abel
Journal:  Circulation       Date:  2009-02-23       Impact factor: 29.690

5.  Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction.

Authors:  Stuart A Cook; Anabel Varela-Carver; Marco Mongillo; Christina Kleinert; Muhammad T Khan; Lucia Leccisotti; Nicola Strickland; Takashi Matsui; Saumya Das; Anthony Rosenzweig; Prakash Punjabi; Paolo G Camici
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Review 6.  Cardiovascular actions of insulin.

Authors:  Ranganath Muniyappa; Monica Montagnani; Kwang Kon Koh; Michael J Quon
Journal:  Endocr Rev       Date:  2007-05-24       Impact factor: 19.871

7.  Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.

Authors:  Hiroyuki Ikeda; Ichiro Shiojima; Yukako Ozasa; Masashi Yoshida; Martin Holzenberger; C Ronald Kahn; Kenneth Walsh; Takashi Igarashi; E Dale Abel; Issei Komuro
Journal:  J Mol Cell Cardiol       Date:  2009-09-08       Impact factor: 5.000

8.  Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction.

Authors:  Sandra Sena; Ping Hu; Dongfang Zhang; Xiaohui Wang; Benjamin Wayment; Curtis Olsen; Erick Avelar; E Dale Abel; Sheldon E Litwin
Journal:  J Mol Cell Cardiol       Date:  2009-02-26       Impact factor: 5.000

9.  Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice.

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Review 10.  Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.

Authors:  S Sarkar; B Ravikumar; R A Floto; D C Rubinsztein
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Review 2.  Myocardial autophagic energy stress responses--macroautophagy, mitophagy, and glycophagy.

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Authors:  Lea M D Delbridge; Kimberley M Mellor; David J Taylor; Roberta A Gottlieb
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Review 4.  This old heart: Cardiac aging and autophagy.

Authors:  Phyllis-Jean Linton; Michael Gurney; David Sengstock; Robert M Mentzer; Roberta A Gottlieb
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Review 5.  Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases.

Authors:  Huayu Shang; Trisha A VanDusseldorp; Ranggui Ma; Yan Zhao; Jason Cholewa; Nelo Eidy Zanchi; Zhi Xia
Journal:  J Physiol Biochem       Date:  2022-06-21       Impact factor: 4.158

Review 6.  Heart Failure in Type 2 Diabetes Mellitus.

Authors:  Helena C Kenny; E Dale Abel
Journal:  Circ Res       Date:  2019-01-04       Impact factor: 17.367

Review 7.  Insulin Signaling and Heart Failure.

Authors:  Christian Riehle; E Dale Abel
Journal:  Circ Res       Date:  2016-04-01       Impact factor: 17.367

8.  Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice.

Authors:  Karla Maria Pires; Marcio Buffolo; Christin Schaaf; J David Symons; James Cox; E Dale Abel; Craig H Selzman; Sihem Boudina
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Review 9.  Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series.

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Review 10.  Insulin signaling in the heart.

Authors:  E Dale Abel
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