Literature DB >> 25327631

CpG-loaded multifunctional cationic nanohydrogel particles as self-adjuvanting glycopeptide antitumor vaccines.

Sebastian Hartmann1, Lutz Nuhn, Björn Palitzsch, Markus Glaffig, Natascha Stergiou, Bastian Gerlitzki, Edgar Schmitt, Horst Kunz, Rudolf Zentel.   

Abstract

Self-adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin T-cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast tumor cells without external adjuvant.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  CpG codelivery; MUC1 glycopeptide; anti-tumor vaccines; cationic nanohydrogels; self-adjuvanting vaccines

Mesh：

Substances：

Year:  2014        PMID： 25327631     DOI： 10.1002/adhm.201400460

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  13 in total

Review 1.  Tumor-associated O-glycans of MUC1: Carriers of the glyco-code and targets for cancer vaccine design.

Authors:  Donella M Beckwith; Maré Cudic
Journal:  Semin Immunol       Date:  2020-01-09       Impact factor: 11.130

2.  pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation.

Authors:  Lutz Nuhn; Nane Vanparijs; Ans De Beuckelaer; Lien Lybaert; Glenn Verstraete; Kim Deswarte; Stefan Lienenklaus; Nikunj M Shukla; Alex C D Salyer; Bart N Lambrecht; Johan Grooten; Sunil A David; Stefaan De Koker; Bruno G De Geest
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-05       Impact factor: 11.205

Review 3.  Cell membrane-derived nanomaterials for biomedical applications.

Authors:  Ronnie H Fang; Yao Jiang; Jean C Fang; Liangfang Zhang
Journal:  Biomaterials       Date:  2017-03-01       Impact factor: 12.479

4.  Core/shell protein-reactive nanogels via a combination of RAFT polymerization and vinyl sulfone postmodification.

Authors:  Nane Vanparijs; Lutz Nuhn; Samantha J Paluck; Maria Kokkinopoulou; Ingo Lieberwirth; Heather D Maynard; Bruno G De Geest
Journal:  Nanomedicine (Lond)       Date:  2016-09-15       Impact factor: 5.307

Review 5.  Immunological Evaluation of Recent MUC1 Glycopeptide Cancer Vaccines.

Authors:  Md Kamal Hossain; Katherine A Wall
Journal:  Vaccines (Basel)       Date:  2016-07-26

6.  Comparative Study of 5'- and 3'-Linked CpG-Antigen Conjugates for the Induction of Cellular Immune Responses.

Authors:  Katrin Kramer; Sarah L Young; Greg F Walker
Journal:  ACS Omega       Date:  2017-01-25

Review 7.  Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy.

Authors:  Dapeng Zhou; Lan Xu; Wei Huang; Torsten Tonn
Journal:  Molecules       Date:  2018-05-31       Impact factor: 4.411

8.  Time-resolved structural evolution during the collapse of responsive hydrogels: The microgel-to-particle transition.

Authors:  Rico Keidel; Ali Ghavami; Dersy M Lugo; Gudrun Lotze; Otto Virtanen; Peter Beumers; Jan Skov Pedersen; Andre Bardow; Roland G Winkler; Walter Richtering
Journal:  Sci Adv       Date:  2018-04-06       Impact factor: 14.136

Review 9.  Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines.

Authors:  Qingjiang Li; Zhongwu Guo
Journal:  Molecules       Date:  2018-06-29       Impact factor: 4.411

10.  Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels.

Authors:  Maximilian Scherger; Evangelia Bolli; Ana Rita Pombo Antunes; Sana Arnouk; Judith Stickdorn; Alexandra Van Driessche; Hansjörg Schild; Stephan Grabbe; Bruno G De Geest; Jo A Van Ginderachter; Lutz Nuhn
Journal:  Cells       Date:  2020-10-01       Impact factor: 6.600
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