Literature DB >> 25327138

A disulfide polymerized protein crystal.

Esben M Quistgaard1.   

Abstract

The vDED coiled coil domain from human BAP29 was crystallized in dimeric and tetrameric forms. For the dimer, a disulfide bond was unexpectedly found to bridge a crystal contact, resulting in complete cross-linking along the c-axis. This indicates that it is in principle possible to design spontaneously polymerizing protein crystals.

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Year:  2014        PMID: 25327138     DOI: 10.1039/c4cc07326f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

Review 1.  Protein stability: a crystallographer's perspective.

Authors:  Marc C Deller; Leopold Kong; Bernhard Rupp
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2016-01-26       Impact factor: 1.056

  1 in total

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