Literature DB >> 25326810

The SNAI1 3'UTR functions as a sponge for multiple migration-/invasion-related microRNAs.

Jun Li1, Hailin Yu, Meili Xi, Duan Ma, Xin Lu.   

Abstract

Accumulating evidence has indicated a large-scale regulatory network generated by 3'untranslated regions (3'UTRs) in cancer. The 3'UTRs act not only in cis but, most likely even more importantly, as trans regulators of gene expression, consequently leading to phenotypic alterations. Here, we found that ectopic expression of SNAI1 3'UTR induced migration and invasion of ovarian cancer cell line RMUG-L without significantly affecting cell viability. Additionally, SNAI1 3'UTR overexpression regulated key epithelial-to-mesenchymal transition (EMT) markers, including SNAI1, Vimentin, and E-cadherin, and functioned as a sponge for multiple migration-/invasion-related microRNAs (miRNAs) in RMUG-L cells. These findings revealed the noncoding function of SNAI1 for the first time.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25326810     DOI： 10.1007/s13277-014-2733-z

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  46 in total

1.  Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites.

Authors:  Rickard Sandberg; Joel R Neilson; Arup Sarma; Phillip A Sharp; Christopher B Burge
Journal:  Science       Date:  2008-06-20       Impact factor: 47.728

Review 2.  Regulatory networks defining EMT during cancer initiation and progression.

Authors:  Bram De Craene; Geert Berx
Journal:  Nat Rev Cancer       Date:  2013-02       Impact factor: 60.716

3.  Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal.

Authors:  Yue Wang; Zhenyu Xu; Junfeng Jiang; Chen Xu; Jiuhong Kang; Lei Xiao; Minjuan Wu; Jun Xiong; Xiaocan Guo; Houqi Liu
Journal:  Dev Cell       Date:  2013-03-28       Impact factor: 12.270

4.  Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22.

Authors:  J B Patel; H N Appaiah; R M Burnett; P Bhat-Nakshatri; G Wang; R Mehta; S Badve; M J Thomson; S Hammond; P Steeg; Y Liu; H Nakshatri
Journal:  Oncogene       Date:  2010-11-08       Impact factor: 9.867

5.  A functional polymorphism at microRNA-629-binding site in the 3'-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population.

Authors:  Lei Yang; Yinyan Li; Mei Cheng; Dongsheng Huang; Jian Zheng; Bin Liu; Xiaoxuan Ling; Qingchu Li; Xin Zhang; Weidong Ji; Yifeng Zhou; Jiachun Lu
Journal:  Carcinogenesis       Date:  2011-11-22       Impact factor: 4.944

6.  Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation.

Authors:  Christine Mayr; Michael T Hemann; David P Bartel
Journal:  Science       Date:  2007-02-22       Impact factor: 47.728

7.  CPEB1 coordinates alternative 3'-UTR formation with translational regulation.

Authors:  Felice-Alessio Bava; Carolina Eliscovich; Pedro G Ferreira; Belen Miñana; Claudia Ben-Dov; Roderic Guigó; Juan Valcárcel; Raúl Méndez
Journal:  Nature       Date:  2013-02-24       Impact factor: 49.962

8.  Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck.

Authors:  Marta Persson; Ywonne Andrén; Joachim Mark; Hugo M Horlings; Fredrik Persson; Göran Stenman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-19       Impact factor: 11.205

9.  Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer.

Authors:  Qin Xu; Qiang Sun; Jianjun Zhang; Jingshuang Yu; Wantao Chen; Zhiyuan Zhang
Journal:  Carcinogenesis       Date:  2012-11-27       Impact factor: 4.944

10.  A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells.

Authors:  Ulrike Burk; Jörg Schubert; Ulrich Wellner; Otto Schmalhofer; Elizabeth Vincan; Simone Spaderna; Thomas Brabletz
Journal:  EMBO Rep       Date:  2008-05-16       Impact factor: 8.807
View more
  7 in total

1.  miR-204 regulates the EMT by targeting snai1 to suppress the invasion and migration of gastric cancer.

Authors:  Zhe Liu; Jin Long; Ruixia Du; Chunlin Ge; Kejian Guo; Yuanhong Xu
Journal:  Tumour Biol       Date:  2016-01-05

2.  Epstein-Barr Virus MicroRNA miR-BART20-5p Suppresses Lytic Induction by Inhibiting BAD-Mediated caspase-3-Dependent Apoptosis.

Authors:  Hyoji Kim; Hoyun Choi; Suk Kyeong Lee
Journal:  J Virol       Date:  2015-11-18       Impact factor: 5.103

3.  SNAI1 promotes the development of HCC through the enhancement of proliferation and inhibition of apoptosis.

Authors:  Jianni Qi; Tao Li; Hongjun Bian; Feifei Li; Ying Ju; Shanshan Gao; Jingran Su; Wanhua Ren; Chengyong Qin
Journal:  FEBS Open Bio       Date:  2016-03-10       Impact factor: 2.693

4.  Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling.

Authors:  Hongwei Guo; Hua Luo; Hebao Yuan; Yudui Xia; Pan Shu; Xin Huang; Yi Lu; Xia Liu; Evan T Keller; Duxin Sun; Jiagang Deng; Jian Zhang
Journal:  Sci Rep       Date:  2017-01-30       Impact factor: 4.379

5.  Knockdown of BRCC3 exerts an anti‑tumor effect on cervical cancer in vitro.

Authors:  Feifang Zhang; Qun Zhou
Journal:  Mol Med Rep       Date:  2018-09-26       Impact factor: 2.952

6.  Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53.

Authors:  Mahsa Alaee; Ghazal Danesh; Manijeh Pasdar
Journal:  PLoS One       Date:  2016-05-04       Impact factor: 3.240

7.  LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer.

Authors:  Yongfu Shao; Meng Ye; Qier Li; Weiliang Sun; Guoliang Ye; Xinjun Zhang; Yunben Yang; Bingxiu Xiao; Junming Guo
Journal:  Oncotarget       Date:  2016-06-21
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.