Chiara Baglioni1, Kai Spiegelhalder2, Wolfram Regen1, Bernd Feige1, Christoph Nissen1, Caterina Lombardo3, Cristiano Violani3, Jürgen Hennig4, Dieter Riemann1. 1. Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Germany. 2. Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Germany: Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Germany. 3. Department of Psychology, Sapienza University of Rome, Italy. 4. Department of Radiology, University of Freiburg Medical Center, Germany.
Abstract
STUDY OBJECTIVES: Alterations in emotional reactivity may play a key role in the pathophysiology of insomnia disorder (ID). However, only few supporting experimental data are currently available. We evaluated in a hypothesis-driven design whether patients with ID present altered amygdale responses to emotional stimuli related and unrelated to the experience of insomnia and, because of chronic hyperarousal, less habituation of amygdala responses. DESIGN: Case-control study. SETTING: Departments of Psychiatry and Psychotherapy and of Radiology of the University of Freiburg Medical Center. PARTICIPANTS: There were 22 patients with ID (15 females; 7 males; age 40.7 ± 12.6 y) and 38 healthy good sleepers (HGS, 21 females; 17 males; age 39.6 ± 8.9 y). INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: In a functional magnetic resonance imaging session, five different blocks of pictures with varying emotional arousal, valence, and content (insomnia-relatedness) were presented. Pictures were presented twice to test for habituation processes. Results showed that patients with ID, compared to HGS, presented heightened amygdala responses to insomnia-related stimuli. Moreover, habituation of amygdale responses was observed only in HGS, but not in patients with ID who showed a mixed pattern of amygdala responses to the second presentation of the stimuli. CONCLUSIONS: The results provide evidence for an insomnia-related emotional bias in patients with ID. Cognitive behavior treatment for ID could benefit from strategies dealing with the emotional charge associated with the disorder. Further studies should clarify the role of ID with respect to habituation of amygdala responses.
STUDY OBJECTIVES: Alterations in emotional reactivity may play a key role in the pathophysiology of insomnia disorder (ID). However, only few supporting experimental data are currently available. We evaluated in a hypothesis-driven design whether patients with ID present altered amygdale responses to emotional stimuli related and unrelated to the experience of insomnia and, because of chronic hyperarousal, less habituation of amygdala responses. DESIGN: Case-control study. SETTING: Departments of Psychiatry and Psychotherapy and of Radiology of the University of Freiburg Medical Center. PARTICIPANTS: There were 22 patients with ID (15 females; 7 males; age 40.7 ± 12.6 y) and 38 healthy good sleepers (HGS, 21 females; 17 males; age 39.6 ± 8.9 y). INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: In a functional magnetic resonance imaging session, five different blocks of pictures with varying emotional arousal, valence, and content (insomnia-relatedness) were presented. Pictures were presented twice to test for habituation processes. Results showed that patients with ID, compared to HGS, presented heightened amygdala responses to insomnia-related stimuli. Moreover, habituation of amygdale responses was observed only in HGS, but not in patients with ID who showed a mixed pattern of amygdala responses to the second presentation of the stimuli. CONCLUSIONS: The results provide evidence for an insomnia-related emotional bias in patients with ID. Cognitive behavior treatment for ID could benefit from strategies dealing with the emotional charge associated with the disorder. Further studies should clarify the role of ID with respect to habituation of amygdala responses.