Yeonsu Song1, Terri Blackwell2, Kristine Yaffe3, Sonia Ancoli-Israel4, Susan Redline5, Katie L Stone2. 1. VA Greater Los Angeles Healthcare System, Geriatric Research, Education, and Clinical Center, Los Angeles, CA. 2. San Francisco Coordinating Centers and California Pacific Medical Center Research Institute, San Francisco, CA. 3. Department of Psychiatry, Neurology, and Epidemiology, School of Medicine, University of California, San Francisco, CA. 4. Department of Psychiatry, School of Medicine, University of California, San Diego, CA. 5. Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Abstract
STUDY OBJECTIVE: To investigate the associations between sleep stage distributions and subsequent decline in cognitive function in older men over time. DESIGN: A population-based prospective substudy of the Osteoporotic Fractures in Men Study. SETTINGS: Six sites in the United States. PARTICIPANTS: Community-dwelling men aged 67 y or older (n = 2,601), who were free of probable dementia at sleep visit. Follow-up averaged 3.4 y. MEASUREMENT AND RESULTS: Sleep stages were identified by in-home polysomnography at the initial sleep visit (2003-2005). Cognitive outcomes were assessed with the Trail Making Test Part B and Modified Mini-Mental State Examination (3MS) at sleep visit and two follow-up visits. After adjusting for multiple confounders compared with men in the lowest quartile of percent of sleep time spent in Stage N1, those in the highest quartile had a twofold increase in cognitive decline for both cognitive tests (adjusted annualized percent change/y: Trail Making Test Part B Q1 = 1.06, Q4 = 2.45, P = 0.01; 3MS Q1 = -0.27, Q4 = -0.48, P = 0.03). In addition, compared with men in the highest quartile, men in the lowest quartile of percent of sleep time in Stage R revealed more cognitive decline on the 3MS (adjusted annualized percent change/y: Q1 = -0.49, Q4 = -0.22, P = 0.003). These findings were consistent even after further adjustment of total sleep time and sleep disordered breathing. No significant relationships between other sleep stages (N2, N3) and cognitive change were found. CONCLUSION: Increased time in Stage N1 and less time in Stage R are associated with worsening cognitive performance in older men over time.
STUDY OBJECTIVE: To investigate the associations between sleep stage distributions and subsequent decline in cognitive function in older men over time. DESIGN: A population-based prospective substudy of the Osteoporotic Fractures in Men Study. SETTINGS: Six sites in the United States. PARTICIPANTS: Community-dwelling men aged 67 y or older (n = 2,601), who were free of probable dementia at sleep visit. Follow-up averaged 3.4 y. MEASUREMENT AND RESULTS: Sleep stages were identified by in-home polysomnography at the initial sleep visit (2003-2005). Cognitive outcomes were assessed with the Trail Making Test Part B and Modified Mini-Mental State Examination (3MS) at sleep visit and two follow-up visits. After adjusting for multiple confounders compared with men in the lowest quartile of percent of sleep time spent in Stage N1, those in the highest quartile had a twofold increase in cognitive decline for both cognitive tests (adjusted annualized percent change/y: Trail Making Test Part B Q1 = 1.06, Q4 = 2.45, P = 0.01; 3MS Q1 = -0.27, Q4 = -0.48, P = 0.03). In addition, compared with men in the highest quartile, men in the lowest quartile of percent of sleep time in Stage R revealed more cognitive decline on the 3MS (adjusted annualized percent change/y: Q1 = -0.49, Q4 = -0.22, P = 0.003). These findings were consistent even after further adjustment of total sleep time and sleep disordered breathing. No significant relationships between other sleep stages (N2, N3) and cognitive change were found. CONCLUSION: Increased time in Stage N1 and less time in Stage R are associated with worsening cognitive performance in older men over time.
Authors: Eric Orwoll; Janet Babich Blank; Elizabeth Barrett-Connor; Jane Cauley; Steven Cummings; Kristine Ensrud; Cora Lewis; Peggy M Cawthon; Robert Marcus; Lynn M Marshall; Joan McGowan; Kathy Phipps; Sherry Sherman; Marcia L Stefanick; Katie Stone Journal: Contemp Clin Trials Date: 2005-10 Impact factor: 2.226
Authors: Robert D Nebes; Daniel J Buysse; Edythe M Halligan; Patricia R Houck; Timothy H Monk Journal: J Gerontol B Psychol Sci Soc Sci Date: 2009-02-09 Impact factor: 4.077
Authors: David M Claman; Susan Redline; Terri Blackwell; Sonia Ancoli-Israel; Susan Surovec; Nancy Scott; Jane A Cauley; Kristine E Ensrud; Katie L Stone Journal: J Clin Sleep Med Date: 2006-10-15 Impact factor: 4.062
Authors: Michael K Scullin; Chenlu Gao; Paul Fillmore; R Lynae Roberts; Natalya Pruett; Donald L Bliwise Journal: Sleep Date: 2019-06-11 Impact factor: 5.849
Authors: Alberto R Ramos; Wassim Tarraf; Benson Wu; Susan Redline; Jianwen Cai; Martha L Daviglus; Linda Gallo; Yasmin Mossavar-Rahmani; Krista M Perreira; Phyllis Zee; Donglin Zeng; Hector M Gonzalez Journal: Alzheimers Dement Date: 2020-01-06 Impact factor: 21.566
Authors: Carmela Alcántara; Mary L Biggs; Karina W Davidson; Joseph A Delaney; Chandra L Jackson; Phyllis C Zee; Steven J C Shea; Susan Redline Journal: Sleep Date: 2016-04-01 Impact factor: 5.849
Authors: Matthew P Pase; Jayandra J Himali; Natalie A Grima; Alexa S Beiser; Claudia L Satizabal; Hugo J Aparicio; Robert J Thomas; Daniel J Gottlieb; Sandford H Auerbach; Sudha Seshadri Journal: Neurology Date: 2017-08-23 Impact factor: 9.910