| Literature DB >> 25323443 |
Emilie Secret1, Marie Maynadier, Audrey Gallud, Arnaud Chaix, Elise Bouffard, Magali Gary-Bobo, Nathalie Marcotte, Olivier Mongin, Khaled El Cheikh, Vincent Hugues, Mélanie Auffan, Céline Frochot, Alain Morère, Philippe Maillard, Mireille Blanchard-Desce, Michael J Sailor, Marcel Garcia, Jean-Olivier Durand, Frédérique Cunin.
Abstract
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.Entities:
Keywords: mannose; nanoparticle; photodynamic therapy; porous silicon; two-photon excitation
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Year: 2014 PMID: 25323443 DOI: 10.1002/adma.201403415
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849