BACKGROUND: Multi-resistantmicroorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida tropicalis e Candida krusei are the main causes of microbial infections. Padina sanctae-crucis is a seaweed often used to check the contamination of ecosystems by materials such as heavy metals, but studies of the antimicrobial activity of the same seaweed were not found. METHODS: The tests for the minimum inhibitory concentration and modulation of microbial resistance, with the use of ethanolic and methanolic extracts of Padina Sanctae-cruces combined with drugs of the class of aminoglycosides and antifungal were used to evaluate the activity against the cited microorganisms. RESULTS: Was observed a modulation of antibiotic activity between the natural products and the E. coli and S. aureus strains, indicating a synergism and antagonism respectively. CONCLUSIONS: The results showed a moderate modulatory effect against some microorganisms studied.
BACKGROUND: Multi-resistantmicroorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida tropicalis e Candida krusei are the main causes of microbial infections. Padina sanctae-crucis is a seaweed often used to check the contamination of ecosystems by materials such as heavy metals, but studies of the antimicrobial activity of the same seaweed were not found. METHODS: The tests for the minimum inhibitory concentration and modulation of microbial resistance, with the use of ethanolic and methanolic extracts of Padina Sanctae-cruces combined with drugs of the class of aminoglycosides and antifungal were used to evaluate the activity against the cited microorganisms. RESULTS: Was observed a modulation of antibiotic activity between the natural products and the E. coli and S. aureus strains, indicating a synergism and antagonism respectively. CONCLUSIONS: The results showed a moderate modulatory effect against some microorganisms studied.
Authors: Henrique D M Coutinho; José G M Costa; Vivyanne S Falcão-Silva; José P Siqueira-Júnior; Edeltrudes O Lima Journal: Comp Immunol Microbiol Infect Dis Date: 2009-09-03 Impact factor: 2.268
Authors: M M Javadpour; M M Juban; W C Lo; S M Bishop; J B Alberty; S M Cowell; C L Becker; M L McLaughlin Journal: J Med Chem Date: 1996-08-02 Impact factor: 7.446
Authors: Henrique D M Coutinho; José G M Costa; Edeltrudes O Lima; Vivyanne S Falcão-Silva; José P Siqueira-Júnior Journal: Chemotherapy Date: 2008-08-12 Impact factor: 2.544
Authors: Henrique D M Coutinho; José G M Costa; Edeltrudes O Lima; Vivyanne S Falcão-Silva; José P Siqueira Journal: BMC Complement Altern Med Date: 2009-05-08 Impact factor: 3.659