Harindra Jayasekara1, Robert J MacInnis2, Allison M Hodge3, John L Hopper2, Graham G Giles2, Robin Room4, Dallas R English2. 1. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia. 2. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia. 3. Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia. 4. Centre for Alcohol Policy Research, Turning Point Alcohol and Drug Centre, Melbourne, Victoria 3065, Australia Centre for Health and Society, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia Centre for Social Research on Alcohol and Drugs, Stockholm University, Stockholm SE-106 91, Sweden.
Abstract
BACKGROUND: Conventionally, cohort studies have assessed the association between alcohol and all-cause mortality by using alcohol intake at enrolment. METHODS: In the Melbourne Collaborative Cohort Study, participants were asked about usual frequency and quantity of beverage-specific alcohol intake for 10-year periods starting at age 20 from which current, past and lifetime intakes were calculated. We used Cox regression to estimate hazard ratios for mortality for 39 577 participants of the Melbourne Collaborative Cohort Study aged 40-69 at baseline. RESULTS: After a mean follow-up of 15 years/person, we identified 4639 deaths. Associations between all-cause mortality and lifetime, current (baseline) and past intake were J shaped, with lower mortality at low intake (e.g. <40 g/day for men and 10 g/day for women using lifetime intake) and elevated mortality at higher intake. For men, consistent light-to-moderate drinking (>0-39/>0-39 g/day) from age 20 to baseline age was associated with a 16% lower mortality, while heavy drinking at both ages (≥80/≥40 and ≥40/0 g/day) was associated with higher mortality compared with stable abstinence. CONCLUSIONS: Our findings support a reduced mortality risk associated with low-dose drinking but also highlight a higher mortality risk for consistent heavy drinking from a young age.
BACKGROUND: Conventionally, cohort studies have assessed the association between alcohol and all-cause mortality by using alcohol intake at enrolment. METHODS: In the Melbourne Collaborative Cohort Study, participants were asked about usual frequency and quantity of beverage-specific alcohol intake for 10-year periods starting at age 20 from which current, past and lifetime intakes were calculated. We used Cox regression to estimate hazard ratios for mortality for 39 577 participants of the Melbourne Collaborative Cohort Study aged 40-69 at baseline. RESULTS: After a mean follow-up of 15 years/person, we identified 4639 deaths. Associations between all-cause mortality and lifetime, current (baseline) and past intake were J shaped, with lower mortality at low intake (e.g. <40 g/day for men and 10 g/day for women using lifetime intake) and elevated mortality at higher intake. For men, consistent light-to-moderate drinking (>0-39/>0-39 g/day) from age 20 to baseline age was associated with a 16% lower mortality, while heavy drinking at both ages (≥80/≥40 and ≥40/0 g/day) was associated with higher mortality compared with stable abstinence. CONCLUSIONS: Our findings support a reduced mortality risk associated with low-dose drinking but also highlight a higher mortality risk for consistent heavy drinking from a young age.
Authors: Erin L Richard; Donna Kritz-Silverstein; Gail A Laughlin; Teresa T Fung; Elizabeth Barrett-Connor; Linda K McEvoy Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Christopher T V Swain; Julie K Bassett; Allison M Hodge; David W Dunstan; Neville Owen; Yi Yang; Harindra Jayasekara; James R Hébert; Nitin Shivappa; Robert J MacInnis; Roger L Milne; Dallas R English; Brigid M Lynch Journal: Int J Behav Nutr Phys Act Date: 2022-03-19 Impact factor: 6.457