AIM: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world today. A previous study has suggested an association of apolipoprotein C3 (APOC3) gene variants with the risk of NAFLD in Asian Indian men living in the Western regions. The present study was carried out with an aim to evaluate the association of demographic features, serum lipid profile and APOC3 gene variants (C-482T and T-455C) NAFLD. METHODS: One hundred and fifty NAFLD patients and 150 age and gender-matched controls were included in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the genotypes of APOC3. Serum lipid profile was analyzed. RESULTS: In the present study, body mass index was not a predictive demographic marker for NAFLD. Serum triglycerides were higher in patients (mean 155.95 ± 59.0) with NAFLD compared to the control group (mean 133.75 ± 44.71) (p = 0.016). APOC3 gene polymorphism T-455C (rs2854116) was significantly associated with NAFLD (p = 0.001). However, we did not find a significant association of C-482T polymorphism (rs2854117) of APOC3 gene with NAFLD. Genotype -455C/C of the SNP, rs2854116 associated significantly with the elevated serum triglycerides in patients. CONCLUSIONS: The polymorphism T-455C in APOC3 gene and elevated serum triglycerides were associated with NAFLD.
AIM: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world today. A previous study has suggested an association of apolipoprotein C3 (APOC3) gene variants with the risk of NAFLD in Asian Indian men living in the Western regions. The present study was carried out with an aim to evaluate the association of demographic features, serum lipid profile and APOC3 gene variants (C-482T and T-455C) NAFLD. METHODS: One hundred and fifty NAFLD patients and 150 age and gender-matched controls were included in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the genotypes of APOC3. Serum lipid profile was analyzed. RESULTS: In the present study, body mass index was not a predictive demographic marker for NAFLD. Serum triglycerides were higher in patients (mean 155.95 ± 59.0) with NAFLD compared to the control group (mean 133.75 ± 44.71) (p = 0.016). APOC3 gene polymorphism T-455C (rs2854116) was significantly associated with NAFLD (p = 0.001). However, we did not find a significant association of C-482T polymorphism (rs2854117) of APOC3 gene with NAFLD. Genotype -455C/C of the SNP, rs2854116 associated significantly with the elevated serum triglycerides in patients. CONCLUSIONS: The polymorphism T-455C in APOC3 gene and elevated serum triglycerides were associated with NAFLD.
Authors: Luca Valenti; Valerio Nobili; Ahmad Al-Serri; Raffaela Rametta; Julian B S Leathart; Marco A Zappa; Paola Dongiovanni; Anna L Fracanzani; Arianna Alterio; Giancarlo Roviaro; Ann K Daly; Silvia Fargion; Christopher P Day Journal: J Hepatol Date: 2011-07-21 Impact factor: 25.083
Authors: Sanjay Kalra; Manoj Vithalani; Gurjeet Gulati; C M Kulkarni; Yogesh Kadam; James Pallivathukkal; Brahmananda Das; Rakesh Sahay; K D Modi Journal: J Assoc Physicians India Date: 2013-07
Authors: C Padmapriyadarsini; K Ramesh; L Sekar; Geetha Ramachandran; Devaraj Reddy; G Narendran; S Sekar; C Chandrasekar; D Anbarasu; Christine Wanke; Soumya Swaminathan Journal: Indian J Med Res Date: 2017-05 Impact factor: 2.375