V Camozzi1, G Bonanni2, A Frigo3, M Piccolo4, S Ferasin5, M Zaninotto6, M Boscaro7, G Luisetto8. 1. Department of Medicine, Unit of Endocrinology, University of Padova, via Ospedale 105, 35128, Padua, Italy. valentina.camozzi@unipd.it. 2. Department of Medicine, Unit of Endocrinology, University of Padova, via Ospedale 105, 35128, Padua, Italy. guglielmo.bonanni@unipd.it. 3. Department of Cardiac, Thoracic and Vascular Sciences, Unit of Biostatistics, Epidemiology and Public Health, University of Padova, via Loredan 18, 35131, Padua, Italy. annachiara.frigo@unipd.it. 4. Department of Medicine, Unit of Endocrinology, University of Padova, via Ospedale 105, 35128, Padua, Italy. michele.piccolo@unipd.it. 5. Department of Medicine, Unit of Endocrinology, University of Padova, via Ospedale 105, 35128, Padua, Italy. sergio.ferasin@unipd.it. 6. Department of Medical Laboratory, University of Padova, via Giustiniani 2, 35128, Padua, Italy. martina.zaninotto@sanita.padova.it. 7. Department of Medicine, Unit of Endocrinology, University of Padova, via Ospedale 105, 35128, Padua, Italy. marco.boscaro@unipd.it. 8. Department of Medicine, Unit of Endocrinology, University of Padova, via Ospedale 105, 35128, Padua, Italy. giovanni.luisetto@unipd.it.
Abstract
PURPOSE: Several clinical studies testify the critical role played by estrogens in male bone metabolism. The aim of our study is to assess the effect of a single injection of testosterone enanthate in a group of hypogonadal men on 17β estradiol serum levels and some bone metabolic parameters. METHOD: Twenty-one hypogonadal males were given one testosterone enanthate injection (250 mg). Blood samples were drawn before the injection and after 1, 2 and 3 weeks. The following variables were measured: Total testosterone (TT), 17β estradiol (17β E2), Sex hormone binding globulin, total alkaline phosphatase, osteocalcin, and C-telopeptide of type I collagen (CTx). RESULTS: After testosterone injection, both TT and 17β E2 increased, peaking 1 week after the injection. Individual observation of the response of 17β E2 to testosterone showed that a subgroup (n = 9) failed to respond with any increase in 17β E2 at any of the weekly tests (group E2-), while the remainder (n = 12) showed a significant increase in 17β E2, which reached a mean value three times higher than at baseline (group E2+). The E2- patients reached a TT peak lower than that observed in the E+ group. CTx serum levels declined progressively in the E2+ group, reaching the significance (p = 0.03) at the end of the study, while it did not change in E- group. CONCLUSION: This study suggests that a single injection of testosterone might have different effects on the production of endogenous estrogens, and a significant reduction of bone resorption parameters takes place only in the patients who show a significant increase of 17ß estradiol in response to testosterone administration.
PURPOSE: Several clinical studies testify the critical role played by estrogens in male bone metabolism. The aim of our study is to assess the effect of a single injection of testosterone enanthate in a group of hypogonadal men on 17β estradiol serum levels and some bone metabolic parameters. METHOD: Twenty-one hypogonadal males were given one testosterone enanthate injection (250 mg). Blood samples were drawn before the injection and after 1, 2 and 3 weeks. The following variables were measured: Total testosterone (TT), 17β estradiol (17β E2), Sex hormone binding globulin, total alkaline phosphatase, osteocalcin, and C-telopeptide of type I collagen (CTx). RESULTS: After testosterone injection, both TT and 17β E2 increased, peaking 1 week after the injection. Individual observation of the response of 17β E2 to testosterone showed that a subgroup (n = 9) failed to respond with any increase in 17β E2 at any of the weekly tests (group E2-), while the remainder (n = 12) showed a significant increase in 17β E2, which reached a mean value three times higher than at baseline (group E2+). The E2- patients reached a TT peak lower than that observed in the E+ group. CTx serum levels declined progressively in the E2+ group, reaching the significance (p = 0.03) at the end of the study, while it did not change in E- group. CONCLUSION: This study suggests that a single injection of testosterone might have different effects on the production of endogenous estrogens, and a significant reduction of bone resorption parameters takes place only in the patients who show a significant increase of 17ß estradiol in response to testosterone administration.
Entities:
Keywords:
Bone metabolism; Bone turnover markers; Estrogens; Hypogonadism; Testosterone
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