| Literature DB >> 25319433 |
Diana Zamora-Olivares1, Tamer S Kaoud, Jiney Jose, Andrew Ellington, Kevin N Dalby, Eric V Anslyn.
Abstract
Five SOX peptides are used to classify the MAPK groups and isoforms thereof using chemometrics. The score plots show excellent classification and accuracy, while support vector machine analysis leads to the quantification of ERK and an ERK inhibitor concentration in kinase mixtures. Examination of the loading plots reveals cross-reactivity among the peptides, and some unexpected surprises.Entities:
Keywords: biosensors; chemometrics; differential sensing; fluorescent probes; mitogen-activated protein kinases
Mesh:
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Year: 2014 PMID: 25319433 DOI: 10.1002/anie.201408256
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN: 1433-7851 Impact factor: 15.336