PURPOSE: Miscibility of the different compounds that make up a solid dispersion based formulation play a crucial role in the drug release profile and physical stability of the solid dispersion as it defines the phase behaviour of the dispersion. The standard technique to obtain information on phase behaviour of a sample is (modulated) differential scanning calorimetry ((M)DSC). However, for ternary mixtures (M)DSC alone is not sufficient to characterize their phase behaviour and to gain insight into the distribution of the active pharmaceutical ingredient (API) in a two-phased polymeric matrix. METHODS: MDSC was combined with complementary surface analysis techniques, specifically time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Three spray-dried model formulations with varying API/PLGA/PVP ratios were analyzed. RESULTS: MDSC, TOF-SIMS and AFM provided insights into differences in drug distribution via the observed surface coverage for 3 differently composed ternary solid dispersions. CONCLUSIONS: Combining MDSC and surface analysis rendered additional insights in the composition of mixed phases in complex systems, like ternary solid dispersions.
PURPOSE: Miscibility of the different compounds that make up a solid dispersion based formulation play a crucial role in the drug release profile and physical stability of the solid dispersion as it defines the phase behaviour of the dispersion. The standard technique to obtain information on phase behaviour of a sample is (modulated) differential scanning calorimetry ((M)DSC). However, for ternary mixtures (M)DSC alone is not sufficient to characterize their phase behaviour and to gain insight into the distribution of the active pharmaceutical ingredient (API) in a two-phased polymeric matrix. METHODS: MDSC was combined with complementary surface analysis techniques, specifically time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Three spray-dried model formulations with varying API/PLGA/PVP ratios were analyzed. RESULTS: MDSC, TOF-SIMS and AFM provided insights into differences in drug distribution via the observed surface coverage for 3 differently composed ternary solid dispersions. CONCLUSIONS: Combining MDSC and surface analysis rendered additional insights in the composition of mixed phases in complex systems, like ternary solid dispersions.
Authors: Ilse Weuts; Frederic Van Dycke; Jody Voorspoels; Steve De Cort; Sigrid Stokbroekx; Ruud Leemans; Marcus E Brewster; Dawei Xu; Brigitte Segmuller; Ya Tsz A Turner; Clive J Roberts; Martyn C Davies; Sheng Qi; Duncan Q M Craig; Mike Reading Journal: J Pharm Sci Date: 2010-06-22 Impact factor: 3.534
Authors: Sandrien Janssens; Ann De Zeure; Amrit Paudel; Jan Van Humbeeck; Patrick Rombaut; Guy Van den Mooter Journal: Pharm Res Date: 2010-03-02 Impact factor: 4.200
Authors: David Alsteens; Vincent Dupres; Sami Yunus; Jean-Paul Latgé; Jürgen J Heinisch; Yves F Dufrêne Journal: Langmuir Date: 2012-11-30 Impact factor: 3.882
Authors: Nikolaos Scoutaris; Andrew L Hook; Paul R Gellert; Clive J Roberts; Morgan R Alexander; David J Scurr Journal: J Mater Sci Mater Med Date: 2011-11-16 Impact factor: 3.896
Authors: Sandrien Janssens; Sophie Nagels; Hector Novoa de Armas; Ward D'Autry; Ann Van Schepdael; Guy Van den Mooter Journal: Eur J Pharm Biopharm Date: 2007-11-19 Impact factor: 5.571
Authors: A Rafati; A Boussahel; K M Shakesheff; A G Shard; C J Roberts; X Chen; D J Scurr; S Rigby-Singleton; P Whiteside; M R Alexander; M C Davies Journal: J Control Release Date: 2012-05-11 Impact factor: 9.776