Literature DB >> 25318658

A pillararene-based ternary drug-delivery system with photocontrolled anticancer drug release.

Guocan Yu1, Wei Yu, Zhengwei Mao, Changyou Gao, Feihe Huang.   

Abstract

A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug (Py-Cbl), a water-soluble pillararene supramolecular container (WP6), and the diblock copolymer methoxy-poly(ethylene glycol)114 -block-poly(L -lysine hydrochloride)200. This DDS successfully addresses three important issues: enhancement of the water solubility of the anticancer prodrug; controlled release of the anticancer drug; accurate and quantitative measurement of the drug release.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  controlled release; drug delivery; host-guest systems; pillararenes; supramolecular chemistry

Mesh：

Substances：

Year:  2014        PMID： 25318658     DOI： 10.1002/smll.201402236

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  17 in total

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Journal:  Chem Sci       Date:  2016-03-02       Impact factor: 9.825

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Journal:  Chem Sci       Date:  2017-04-19       Impact factor: 9.825
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