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Literature DB >> 25318123

Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections.

Jinhong Chang¹, Timothy M Block, Ju-Tao Guo.

Abstract

Sadat et al. reported in the 24 April 2014 issue of the New England Journal of Medicine that patients genetically deficient in the gene encoding mannosyl-oligosaccharide glucosidase (MOGS), also known as endoplasmic reticulum (ER) glucosidase I, manifested a severe hypogammaglobulinaemia without clinical evidence of an infectious diathesis. This paradox phenomenon is, at least in part, because the impaired N-linked glycan processing of the patients compromises their ability to support efficient replication and cellular entry of viruses. This finding unambiguously validates ER glucosidases as valuable targets for antiviral agents against a broad-spectrum of enveloped viruses.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
alpha-Glucosidases

Year: 2014 PMID： 25318123 PMCID： PMC4446249 DOI： 10.3851/IMP2907

Source DB: PubMed Journal: Antivir Ther ISSN： 1359-6535

20 in total

1. Sequencing of N-linked oligosaccharides directly from protein gels: in-gel deglycosylation followed by matrix-assisted laser desorption/ionization mass spectrometry and normal-phase high-performance liquid chromatography.

Authors: B Küster; S F Wheeler; A P Hunter; R A Dwek; D J Harvey
Journal: Anal Biochem Date: 1997-07-15 Impact factor: 3.365

2. Glycosylation, hypogammaglobulinemia, and resistance to viral infections.

Authors: Mohammed A Sadat; Susan Moir; Tae-Wook Chun; Paolo Lusso; Gerardo Kaplan; Lynne Wolfe; Matthew J Memoli; Miao He; Hugo Vega; Leo J Y Kim; Yan Huang; Nadia Hussein; Elma Nievas; Raquel Mitchell; Mary Garofalo; Aaron Louie; Derek C Ireland; Claire Grunes; Raffaello Cimbro; Vyomesh Patel; Genevieve Holzapfel; Daniel Salahuddin; Tyler Bristol; David Adams; Beatriz E Marciano; Madhuri Hegde; Yuxing Li; Katherine R Calvo; Jennifer Stoddard; J Shawn Justement; Jerome Jacques; Debra A Long Priel; Danielle Murray; Peter Sun; Douglas B Kuhns; Cornelius F Boerkoel; John A Chiorini; Giovanni Di Pasquale; Daniela Verthelyi; Sergio D Rosenzweig
Journal: N Engl J Med Date: 2014-04-09 Impact factor: 91.245

3. A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency.

Authors: G J Gerwig; E Bause; L K Nuytinck; J F Vliegenthart; W Breuer; J P Kamerling; M F Espeel; J J Martin; N W Chan; G A Dacremont
Journal: Am J Hum Genet Date: 2000-04-28 Impact factor: 11.025

Review 4. The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo.

Authors: Robert M Anthony; Falk Nimmerjahn
Journal: Curr Opin Organ Transplant Date: 2011-02 Impact factor: 2.640

5. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.

Authors: D W Vaughn; S Green; S Kalayanarooj; B L Innis; S Nimmannitya; S Suntayakorn; T P Endy; B Raengsakulrach; A L Rothman; F A Ennis; A Nisalak
Journal: J Infect Dis Date: 2000-01 Impact factor: 5.226

6. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.

Authors: Ming-Fang Wu; Szu-Ting Chen; An-Hang Yang; Wan-Wan Lin; Yi-Ling Lin; Nien-Jung Chen; I-Shuen Tsai; Lei Li; Shie-Liang Hsieh
Journal: Blood Date: 2012-11-14 Impact factor: 22.113

7. The safety and efficacy of combination N-butyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and 200-500 CD4 cells/mm3.

Authors: M A Fischl; L Resnick; R Coombs; A B Kremer; J C Pottage; R J Fass; K H Fife; W G Powderly; A C Collier; R L Aspinall
Journal: J Acquir Immune Defic Syndr (1988) Date: 1994-02

8. CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality.

Authors: Szu-Ting Chen; Ren-Shyan Liu; Ming-Fang Wu; Yi-Ling Lin; Se-Yi Chen; David Tat-Wei Tan; Teh-Ying Chou; I-Shuen Tsai; Lei Li; Shie-Liang Hsieh
Journal: PLoS Pathog Date: 2012-04-19 Impact factor: 6.823

Review 9. Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions.

Authors: Jinhong Chang; Timothy M Block; Ju-Tao Guo
Journal: Antiviral Res Date: 2013-06-29 Impact factor: 5.970

10. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Authors: Travis K Warren; Jay Wells; Rekha G Panchal; Kelly S Stuthman; Nicole L Garza; Sean A Van Tongeren; Lian Dong; Cary J Retterer; Brett P Eaton; Gianluca Pegoraro; Shelley Honnold; Shanta Bantia; Pravin Kotian; Xilin Chen; Brian R Taubenheim; Lisa S Welch; Dena M Minning; Yarlagadda S Babu; William P Sheridan; Sina Bavari
Journal: Nature Date: 2014-03-02 Impact factor: 49.962

8 in total

1. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.

Authors: Julia Ma; Shuo Wu; Xuexiang Zhang; Fang Guo; Katherine Yang; Jia Guo; Qing Su; Huagang Lu; Patrick Lam; Yuhuan Li; Zhengyin Yan; William Kinney; Ju-Tao Guo; Timothy M Block; Jinhong Chang; Yanming Du
Journal: ACS Med Chem Lett Date: 2017-01-17 Impact factor: 4.345

2. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.

Authors: Julia Ma; Xuexiang Zhang; Veronica Soloveva; Travis Warren; Fang Guo; Shuo Wu; Huagang Lu; Jia Guo; Qing Su; Helen Shen; Eric Solon; Mary Ann Comunale; Anand Mehta; Ju-Tao Guo; Sina Bavari; Yanming Du; Timothy M Block; Jinhong Chang
Journal: Antiviral Res Date: 2017-12-15 Impact factor: 5.970

Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections.

1. Sequencing of N-linked oligosaccharides directly from protein gels: in-gel deglycosylation followed by matrix-assisted laser desorption/ionization mass spectrometry and normal-phase high-performance liquid chromatography.

2. Glycosylation, hypogammaglobulinemia, and resistance to viral infections.

3. A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency.

Review 4. The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo.

5. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.

6. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.

7. The safety and efficacy of combination N-butyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and 200-500 CD4 cells/mm3.

8. CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality.

Review 9. Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions.

10. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

1. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.

2. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.

3. Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly.

4. A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein.

Review 5. Immunological aspects of congenital disorders of glycosylation (CDG): a review.

6. Whole genome sequence analysis of the TALLYHO/Jng mouse.

7. Updated clinical and glycomic features of mannosyl-oligosaccharide glucosidase deficiency: Two case reports.

8. Editorial: Host Genetics in Viral Pathogenesis and Control.