Literature DB >> 2531786

People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.

B Sacks1, S Smith.   

Abstract

The mydriatic response to eyedrops of the anticholinergic agent tropicamide at very low concentration (0.01%) has been studied in people with Down's syndrome. By comparison with healthy subjects people with Down's syndrome had responses approximately three times greater, suggesting a peripheral imbalance between cholinergic and adrenergic autonomic influences.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2531786      PMCID： PMC1031641          DOI： 10.1136/jnnp.52.11.1294

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  12 in total

1.  Atropine response of the eyes in mongolism.

Authors:  J H PRIEST
Journal:  Am J Dis Child       Date:  1960-12

2.  Atropine in mongolism.

Authors:  J M BERG; M W BRANDON; B H KIRMAN
Journal:  Lancet       Date:  1959-09-26       Impact factor: 79.321

3.  Neurochemical studies of early-onset Alzheimer's disease. Possible influence on treatment.

Authors:  P T Francis; A M Palmer; N R Sims; D M Bowen; A N Davison; M M Esiri; D Neary; J S Snowden; G K Wilcock
Journal:  N Engl J Med       Date:  1985-07-04       Impact factor: 91.245

4.  Cholinergic-rich brain transplants reverse alcohol-induced memory deficits.

Authors:  T Arendt; Y Allen; J Sinden; M M Schugens; R M Marchbanks; P L Lantos; J A Gray
Journal:  Nature       Date:  1988-03-31       Impact factor: 49.962

5.  A simple diagnostic test for pupillary abnormality in diabetic autonomic neuropathy.

Authors:  S A Smith; R R Dewhirst
Journal:  Diabet Med       Date:  1986-01       Impact factor: 4.359

6.  Hyper-reactivity to atropine in Down's syndrome.

Authors:  W S Harris; R M Goodman
Journal:  N Engl J Med       Date:  1968-08-22       Impact factor: 91.245

7.  Presynaptic cholinergic dysfunction in patients with dementia.

Authors:  N R Sims; D M Bowen; S J Allen; C C Smith; D Neary; D J Thomas; A N Davison
Journal:  J Neurochem       Date:  1983-02       Impact factor: 5.372

8.  Down syndrome and short-term memory impairment: a storage or retrieval deficit?

Authors:  M L McDade; S Adler
Journal:  Am J Ment Defic       Date:  1980-05

9.  Neurochemical characteristics of early and late onset types of Alzheimer's disease.

Authors:  M N Rossor; L L Iversen; G P Reynolds; C Q Mountjoy; M Roth
Journal:  Br Med J (Clin Res Ed)       Date:  1984-03-31

10.  Anticholinergic sensitivity in patients with dementia of the Alzheimer type and age-matched controls. A dose-response study.

Authors:  T Sunderland; P N Tariot; R M Cohen; H Weingartner; E A Mueller; D L Murphy
Journal:  Arch Gen Psychiatry       Date:  1987-05
View more
  9 in total

1.  Probing peripheral and central cholinergic system responses.

Authors:  C A Naranjo; J Fourie; N Herrmann; K L Lanctôt; C Birt; K K Yau
Journal:  J Psychiatry Neurosci       Date:  2000-09       Impact factor: 6.186

Review 2.  Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders.

Authors:  H Potter
Journal:  Am J Hum Genet       Date:  1991-06       Impact factor: 11.025

3.  The use of pupillometry in the assessment of cardiac autonomic function in elite different type trained athletes.

Authors:  Antonia Kaltsatou; Evangelia Kouidi; Dimitrios Fotiou; Pantazis Deligiannis
Journal:  Eur J Appl Physiol       Date:  2011-01-23       Impact factor: 3.078

4.  Down's syndrome fibroblasts exhibit enhanced inositol uptake.

Authors:  B R Fruen; B R Lester
Journal:  Biochem J       Date:  1990-08-15       Impact factor: 3.857

5.  Homocysteine metabolism in children with Down syndrome: in vitro modulation.

Authors:  M Pogribna; S Melnyk; I Pogribny; A Chango; P Yi; S J James
Journal:  Am J Hum Genet       Date:  2001-06-05       Impact factor: 11.025

6.  Sensitive pupil response of early-onset alzheimer's patients to a dilute mixture of cholinergic antagonist and α-Adrenergic stimulant.

Authors:  A Takagi; M Miyao; S Ishihara; H Sakakibara; T Kondo; H Toyoshima; K Kono; A Iguchi
Journal:  Environ Health Prev Med       Date:  1999-04       Impact factor: 3.674

7.  Pupillary Dilation in Research: More than Meets the Eye.

Authors:  Jacob Szpernal; Jane A Bachman Groth; Niamh Wynne; Vesper Williams; Ryan Spellecy; Catherine Thuruthumaly; Joseph Carroll
Journal:  Curr Eye Res       Date:  2022-05-02       Impact factor: 2.555

8.  Cardiac autonomic modulation of children with Down syndrome.

Authors:  Tatiana Dias de Carvalho; Luiz Carlos de Abreu; Zan Mustacchi; Luiz Carlos Marques Vanderlei; Moacir Fernandes Godoy; Rodrigo Daminello Raimundo; Celso Ferreira Filho; Talita Dias da Silva; Laura Guilhoto; Viviane Perico; Vivian Ribeiro Finotti; Celso Ferreira
Journal:  Pediatr Cardiol       Date:  2014-08-28       Impact factor: 1.655

9.  Trying to see, failing to focus: near visual impairment in Down syndrome.

Authors:  Lesley Doyle; Kathryn J Saunders; Julie-Anne Little
Journal:  Sci Rep       Date:  2016-02-05       Impact factor: 4.379
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.