BACKGROUND: Inactivated poliovirus vaccine (IPV) is rarely used in tropical developing countries. To generate additional scientific information, especially on the possible emergence of vaccine-derived polioviruses (VDPVs) in an IPV-only environment, we initiated an IPV introduction project in Yogyakarta, an Indonesian province. In this report, we present the coverage, immunity, and VDPV surveillance results. METHODS: In Yogyakarta, we established environmental surveillance starting in 2004; and conducted routine immunization coverage and seroprevalence surveys before and after a September 2007 switch from oral poliovirus vaccine (OPV) to IPV, using standard coverage and serosurvey methods. Rates and types of polioviruses found in sewage samples were analyzed, and all poliovirus isolates after the switch were sequenced. RESULTS: Vaccination coverage (>95%) and immunity (approximately 100%) did not change substantially before and after the IPV switch. No VDPVs were detected. Before the switch, 58% of environmental samples contained Sabin poliovirus; starting 6 weeks after the switch, Sabin polioviruses were rarely isolated, and if they were, genetic sequencing suggested recent introductions. CONCLUSIONS: This project demonstrated that under almost ideal conditions (good hygiene, maintenance of universally high IPV coverage, and corresponding high immunity against polioviruses), no emergence and circulation of VDPV could be detected in a tropical developing country setting.
BACKGROUND: Inactivated poliovirus vaccine (IPV) is rarely used in tropical developing countries. To generate additional scientific information, especially on the possible emergence of vaccine-derived polioviruses (VDPVs) in an IPV-only environment, we initiated an IPV introduction project in Yogyakarta, an Indonesian province. In this report, we present the coverage, immunity, and VDPV surveillance results. METHODS: In Yogyakarta, we established environmental surveillance starting in 2004; and conducted routine immunization coverage and seroprevalence surveys before and after a September 2007 switch from oral poliovirus vaccine (OPV) to IPV, using standard coverage and serosurvey methods. Rates and types of polioviruses found in sewage samples were analyzed, and all poliovirus isolates after the switch were sequenced. RESULTS: Vaccination coverage (>95%) and immunity (approximately 100%) did not change substantially before and after the IPV switch. No VDPVs were detected. Before the switch, 58% of environmental samples contained Sabin poliovirus; starting 6 weeks after the switch, Sabin polioviruses were rarely isolated, and if they were, genetic sequencing suggested recent introductions. CONCLUSIONS: This project demonstrated that under almost ideal conditions (good hygiene, maintenance of universally high IPV coverage, and corresponding high immunity against polioviruses), no emergence and circulation of VDPV could be detected in a tropical developing country setting.
Authors: Andrés Lizasoain; Fernanda M Burlandy; Matías Victoria; Luis F López Tort; Edson E da Silva; Rodney Colina Journal: Food Environ Virol Date: 2018-06-16 Impact factor: 2.778
Authors: Margaret Farrell; Lee M Hampton; Stephanie Shendale; Lisa Menning; Alejandro Ramirez Gonzalez; Julie Garon; Samantha B Dolan; Gaël Maufras du Châtellier; Sarah Wanyoike; Diana Chang Blanc; Manish M Patel Journal: J Infect Dis Date: 2017-07-01 Impact factor: 5.226
Authors: Radboud J Duintjer Tebbens; Mark A Pallansch; Stephen L Cochi; Steven G F Wassilak; Kimberly M Thompson Journal: BMC Infect Dis Date: 2015-09-24 Impact factor: 3.090
Authors: Nicolette A Zhou; Christine S Fagnant-Sperati; Evans Komen; Benlick Mwangi; Johnstone Mukubi; James Nyangao; Joanne Hassan; Agnes Chepkurui; Caroline Maina; Walda B van Zyl; Peter N Matsapola; Marianne Wolfaardt; Fhatuwani B Ngwana; Stacey Jeffries-Miles; Angela Coulliette-Salmond; Silvia Peñaranda; Jeffry H Shirai; Alexandra L Kossik; Nicola K Beck; Robyn Wilmouth; David S Boyle; Cara C Burns; Maureen B Taylor; Peter Borus; John Scott Meschke Journal: Food Environ Virol Date: 2019-11-02 Impact factor: 2.778