Literature DB >> 25316784

Too much success for recent groundbreaking epigenetic experiments.

Gregory Francis1.   

Abstract

An article reporting statistical evidence for epigenetic transfer of learned behavior has important implications, if true. With random sampling, real effects do not always result in rejection of the null hypothesis, but the reported experiments were uniformly successful. Such an outcome is expected to occur with a probability of 0.004.
Copyright © 2014 by the Genetics Society of America.

Keywords:  behavior; epigenetics; methods; power; statistics

Mesh：

Year:  2014        PMID： 25316784      PMCID： PMC4196602          DOI： 10.1534/genetics.114.163998

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  12 in total

1.  Too good to be true: publication bias in two prominent studies from experimental psychology.

Authors:  Gregory Francis
Journal:  Psychon Bull Rev       Date:  2012-04

2.  An exploratory test for an excess of significant findings.

Authors:  John P A Ioannidis; Thomas A Trikalinos
Journal:  Clin Trials       Date:  2007       Impact factor: 2.486

3.  Epigenetics: a lingering smell?

Authors:  Leonie Welberg
Journal:  Nat Rev Neurosci       Date:  2014-01       Impact factor: 34.870

4.  Believe it or not: how much can we rely on published data on potential drug targets?

Authors:  Florian Prinz; Thomas Schlange; Khusru Asadullah
Journal:  Nat Rev Drug Discov       Date:  2011-08-31       Impact factor: 84.694

5.  Reply to Gregory Francis.

Authors:  Brian G Dias; Kerry J Ressler
Journal:  Genetics       Date:  2014-10       Impact factor: 4.562

6.  When are results too good to be true?

Authors:  Gary A Churchill
Journal:  Genetics       Date:  2014-10       Impact factor: 4.562

7.  Epigenetics: The sins of the father.

Authors:  Virginia Hughes
Journal:  Nature       Date:  2014-03-06       Impact factor: 49.962

8.  Reproducibility.

Authors:  Marcia McNutt
Journal:  Science       Date:  2014-01-17       Impact factor: 47.728

9.  Policy: NIH plans to enhance reproducibility.

Authors:  Francis S Collins; Lawrence A Tabak
Journal:  Nature       Date:  2014-01-30       Impact factor: 49.962

10.  The frequency of excess success for articles in Psychological Science.

Authors:  Gregory Francis
Journal:  Psychon Bull Rev       Date:  2014-10
View more
  10 in total

1.  When are results too good to be true?

Authors:  Gary A Churchill
Journal:  Genetics       Date:  2014-10       Impact factor: 4.562

Review 2.  The sources of adaptive variation.

Authors:  Deborah Charlesworth; Nicholas H Barton; Brian Charlesworth
Journal:  Proc Biol Sci       Date:  2017-05-31       Impact factor: 5.349

3.  Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background.

Authors:  Gregory R Rompala; Andrey Finegersh; Michelle Slater; Gregg E Homanics
Journal:  Alcohol       Date:  2016-11-05       Impact factor: 2.405

Review 4.  Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations.

Authors:  Andrey Finegersh; Gregory R Rompala; David I K Martin; Gregg E Homanics
Journal:  Alcohol       Date:  2015-03-30       Impact factor: 2.405

5.  Epigenetic inheritance and evolution: a historian's perspective.

Authors:  Laurent Loison
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2021-04-19       Impact factor: 6.671

Review 6.  Cardinal role of the environment in stress induced changes across life stages and generations.

Authors:  Terence Y Pang; Jazmine D W Yaeger; Cliff H Summers; Rupshi Mitra
Journal:  Neurosci Biobehav Rev       Date:  2021-02-04       Impact factor: 9.052

7.  Excess success for three related papers on racial bias.

Authors:  Gregory Francis
Journal:  Front Psychol       Date:  2015-05-01

8.  Excess success for psychology articles in the journal science.

Authors:  Gregory Francis; Jay Tanzman; William J Matthews
Journal:  PLoS One       Date:  2014-12-04       Impact factor: 3.240

9.  A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans.

Authors:  Luis R Saraiva; Fernando Riveros-McKay; Massimo Mezzavilla; Eman H Abou-Moussa; Charles J Arayata; Melanie Makhlouf; Casey Trimmer; Ximena Ibarra-Soria; Mona Khan; Laura Van Gerven; Mark Jorissen; Matthew Gibbs; Ciaran O'Flynn; Scott McGrane; Peter Mombaerts; John C Marioni; Joel D Mainland; Darren W Logan
Journal:  Sci Adv       Date:  2019-07-31       Impact factor: 14.136

Review 10.  Implications of "Too Good to Be True" for Replication, Theoretical Claims, and Experimental Design: An Example Using Prominent Studies of Racial Bias.

Authors:  Gregory Francis
Journal:  Front Psychol       Date:  2016-09-22
  10 in total

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