Literature DB >> 25316381

Mechanism and Regulation of Autophagy and Its Role in Neuronal Diseases.

Zhiping Hu1, Binbin Yang2, Xiaoye Mo3, Han Xiao1.   

Abstract

Autophagy is a constitutive lysosomal catabolic pathway that degrades damaged organelles and protein aggregates. Neuronal survival is highly dependent on autophagy due to its post-mitotic nature, polarized morphology, and active protein trafficking. Autophagic dysfunction has been linked to several neuronal diseases. Our understanding is still incomplete but may highlight up-to-date findings on how autophagy is executed and regulated at the molecular level and its role in neurodegenerative diseases (including Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS)), brain ischemia, and myelin diseases, hence providing attractive new avenues for the development of treatment strategies to combat neuronal diseases.

Entities:  

Keywords:  Autophagy; Autophagy flux; Brain ischemia; Myelin disease; Neurodegenerative diseases; Neurons

Mesh：

Substances：

Year:  2014        PMID： 25316381     DOI： 10.1007/s12035-014-8921-4

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  253 in total

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Journal:  Eur J Biochem       Date:  2002-04

Review 2.  Methods for monitoring autophagy.

Authors:  Noboru Mizushima
Journal:  Int J Biochem Cell Biol       Date:  2004-12       Impact factor: 5.085

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Journal:  J Biosci       Date:  2006-03       Impact factor: 1.826

Review 4.  Huntington's Disease.

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Journal:  Cold Spring Harb Perspect Biol       Date:  2011-06-01       Impact factor: 10.005

5.  The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.

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Journal:  J Biol Chem       Date:  2001-09-27       Impact factor: 5.157

6.  HMGB1: a novel Beclin 1-binding protein active in autophagy.

Authors:  Rui Kang; Kristen M Livesey; Herbert J Zeh; Michael T Loze; Daolin Tang
Journal:  Autophagy       Date:  2010-11-16       Impact factor: 16.016

7.  Hierarchy of Atg proteins in pre-autophagosomal structure organization.

Authors:  Kuninori Suzuki; Yuka Kubota; Takayuki Sekito; Yoshinori Ohsumi
Journal:  Genes Cells       Date:  2007-02       Impact factor: 1.891

8.  Regulation of autophagy by cytoplasmic p53.

Authors:  Ezgi Tasdemir; M Chiara Maiuri; Lorenzo Galluzzi; Ilio Vitale; Mojgan Djavaheri-Mergny; Marcello D'Amelio; Alfredo Criollo; Eugenia Morselli; Changlian Zhu; Francis Harper; Ulf Nannmark; Chrysanthi Samara; Paolo Pinton; José Miguel Vicencio; Rosa Carnuccio; Ute M Moll; Frank Madeo; Patrizia Paterlini-Brechot; Rosario Rizzuto; Gyorgy Szabadkai; Gérard Pierron; Klas Blomgren; Nektarios Tavernarakis; Patrice Codogno; Francesco Cecconi; Guido Kroemer
Journal:  Nat Cell Biol       Date:  2008-05-04       Impact factor: 28.824

Review 9.  Regulation mechanisms and signaling pathways of autophagy.

Authors:  Congcong He; Daniel J Klionsky
Journal:  Annu Rev Genet       Date:  2009       Impact factor: 16.830

10.  Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.

Authors:  Sandra Maday; Karen E Wallace; Erika L F Holzbaur
Journal:  J Cell Biol       Date:  2012-02-13       Impact factor: 10.539
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  24 in total

1.  Activation of Autophagy Contributes to the Angiotensin II-Triggered Apoptosis in a Dopaminergic Neuronal Cell Line.

Authors:  Qing Gao; Teng Jiang; Hong-Rui Zhao; Liang Wu; You-Yong Tian; Zhou Ou; Li Zhang; Yang Pan; Jie Lu; Ying-Dong Zhang
Journal:  Mol Neurobiol       Date:  2015-04-23       Impact factor: 5.590

2.  6-OHDA Induces Oxidation of F-box Protein Fbw7β by Chaperone-Mediated Autophagy in Parkinson's Model.

Authors:  Xiufeng Wang; Heng Zhai; Fang Wang
Journal:  Mol Neurobiol       Date:  2017-07-22       Impact factor: 5.590

3.  Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury.

Authors:  Min Wang; Yu-Jiao Li; Yi Ding; Hui-Nan Zhang; Ting Sun; Kun Zhang; Le Yang; Yan-Yan Guo; Shui-Bing Liu; Ming-Gao Zhao; Yu-Mei Wu
Journal:  Mol Neurobiol       Date:  2015-01-07       Impact factor: 5.590

Review 4.  Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects.

Authors:  Hongyi Li; Yang Yang; Weiqi Hong; Mengyuan Huang; Min Wu; Xia Zhao
Journal:  Signal Transduct Target Ther       Date:  2020-01-03

5.  Poloxamer 188 Attenuates Cerebral Hypoxia/Ischemia Injury in Parallel with Preventing Mitochondrial Membrane Permeabilization and Autophagic Activation.

Authors:  Chengliang Luo; Qianqian Li; Yuan Gao; Xi Shen; Lu Ma; Qiong Wu; Zufeng Wang; Mingyang Zhang; Ziqin Zhao; Xiping Chen; Luyang Tao
Journal:  J Mol Neurosci       Date:  2015-05-13       Impact factor: 3.444

Review 6.  Autophagy core machinery: overcoming spatial barriers in neurons.

Authors:  Aileen R Ariosa; Daniel J Klionsky
Journal:  J Mol Med (Berl)       Date:  2016-08-20       Impact factor: 4.599

Review 7.  Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric.

Authors:  Zuné Jansen van Rensburg; Shameemah Abrahams; Soraya Bardien; Colin Kenyon
Journal:  Mol Neurobiol       Date:  2021-08-23       Impact factor: 5.590

8.  Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.

Authors:  M Szatmári-Tóth; E Kristóf; Z Veréb; S Akhtar; A Facskó; L Fésüs; A Kauppinen; K Kaarniranta; G Petrovski
Journal:  Cell Death Dis       Date:  2016-09-08       Impact factor: 8.469

9.  Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7).

Authors:  Yuhai Zhao; Peter N Alexandrov; Vivian Jaber; Walter J Lukiw
Journal:  Genes (Basel)       Date:  2016-12-05       Impact factor: 4.096

10.  Autophagy biomarkers in CSF correlates with infarct size, clinical severity and neurological outcome in AIS patients.

Authors:  Honghong Li; Shuwei Qiu; Xiangpen Li; Mei Li; Ying Peng
Journal:  J Transl Med       Date:  2015-11-14       Impact factor: 5.531
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