Bu-Qing Ma1, Mao Zhang2, Li Ba3. 1. Department of Emergency, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310000, PR China; Department of Emergency, The Third People's Hospital of Hangzhou, 38 West Lake Avenue, Hangzhou 310000, PR China. 2. Department of Emergency, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310000, PR China. 3. Department of Emergency, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310000, PR China. Electronic address: hijiang123@163.com.
Abstract
BACKGROUND: Plasma pituitary adenylate cyclase activating polypeptide (PACAP) concentrations are elevated after traumatic brain injury. We assessed the prognostic value of PACAP for short-term and long-term mortality of acute intracerebral hemorrhage (ICH) patients. METHODS: A total of 150 patients and 150 age- and gender- matched healthy controls were recruited. The plasma PACAP concentrations were measured using sandwich immunoassays. ICH severity was assessed using hematoma volume and National Institutes of Health Stroke Scale (NIHSS) score. The end points included 1-week mortality and 6-month mortality. The relationships between plasma PACAP concentrations and ICH severity and the end points were analyzed statistically. RESULTS: Plasma PACAP concentrations were statistically significantly higher in the ICH patients than in the healthy controls and were correlated positively with hematoma volumes and NIHSS scores using a multivariate linear regression. Multivariate analysis results indicated that plasma PACAP concentration was an independent predictor of 1-week mortality, 6-month mortality and 6-month overall survival. It also had high predictive value based on receiver operating characteristic curve. CONCLUSIONS: Plasma PACAP concentrations are increased and are highly associated with the severity of ICH; PACAP may be a good predictor of short-term and long-term mortality of ICH.
BACKGROUND: Plasma pituitary adenylate cyclase activating polypeptide (PACAP) concentrations are elevated after traumatic brain injury. We assessed the prognostic value of PACAP for short-term and long-term mortality of acute intracerebral hemorrhage (ICH) patients. METHODS: A total of 150 patients and 150 age- and gender- matched healthy controls were recruited. The plasma PACAP concentrations were measured using sandwich immunoassays. ICH severity was assessed using hematoma volume and National Institutes of Health Stroke Scale (NIHSS) score. The end points included 1-week mortality and 6-month mortality. The relationships between plasma PACAP concentrations and ICH severity and the end points were analyzed statistically. RESULTS: Plasma PACAP concentrations were statistically significantly higher in the ICHpatients than in the healthy controls and were correlated positively with hematoma volumes and NIHSS scores using a multivariate linear regression. Multivariate analysis results indicated that plasma PACAP concentration was an independent predictor of 1-week mortality, 6-month mortality and 6-month overall survival. It also had high predictive value based on receiver operating characteristic curve. CONCLUSIONS: Plasma PACAP concentrations are increased and are highly associated with the severity of ICH; PACAP may be a good predictor of short-term and long-term mortality of ICH.
Authors: Daniel Pham; Beata Polgar; Tunde Toth; Adel Jungling; Norbert Kovacs; Istvan Balas; Endre Pal; Dora Szabo; Balazs Daniel Fulop; Dora Reglodi; Zalan Szanto; Robert Herczeg; Attila Gyenesei; Andrea Tamas Journal: Geroscience Date: 2022-02-26 Impact factor: 7.581
Authors: Dora Szabo; Zsolt Sarszegi; Beata Polgar; Eva Saghy; Adam Nemeth; Dora Reglodi; Andras Makkos; Aniko Gorbe; Zsuzsanna Helyes; Peter Ferdinandy; Robert Herczeg; Attila Gyenesei; Attila Cziraki; Andrea Tamas Journal: Int J Mol Sci Date: 2021-03-12 Impact factor: 5.923