A Onat 1 , N Çoban 2 , G Can 3 , M Yüksel 4 , A Karagöz 5 , H Yüksel 1 , E Ademoğlu 6 , N Erginel-Ünaltuna 2 Show Affiliations »
Abstract
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OBJECTIVE: We determined whether U-shaped relationships exist between serum lipoprotein[Lp](a) and cardiometabolic risk. METHODS: In population-based nondiabetic and diabetic middle-aged adults (n=1 428 and 241, respectively) who had been genotyped for the LPA rs10455872 A>G polymorphism, we adjusted the Lp(a) concentration for the effects of genotype and other covariates . Via sex-specific equations we estimated expected Lp(a ) concentration in each participant, and the quotient between observed to expected Lp(a ) values was determined. Lp(a ) and Lp(a ) quotient tertiles served to identify non-linear associations with outcomes. RESULTS: Incident 81 cases of diabetes and 128 of coronary heart disease (CHD) developed at 5.1 years' follow-up . Lp(a ) concentration was linearly associated with the LPA genotype, gender, total cholesterol, (inversely) fasting insulin , which together with age formed the variables to derive the equations. In logistic regression for incident diabetes, the low Lp(a ) quotient tertile was a predictor (RR 1.95 [95%CI 1.10; 3.47]) alike the low Lp(a ) tertile, additively to major confounders. Cox regression models comprising sex, age, LPA genotype, smoking status, systolic pressure and serum HDL-cholesterol disclosed that, compared with the mid-tertile, both low (HR 1.77) and high Lp(a ) quotient tertiles significantly predicted incident CHD, especially in women. CONCLUSION: Elevated cardiometabolic risk is conferred by apparently reduced circulating Lp(a ) assays supporting the notion that "low" serum Lp(a ), mediating autoimmune activation, is a major determinant of cardiometabolic risk. © Georg Thieme Verlag KG Stuttgart · New York.
RCT Entities: Population
Interventions
Outcomes
OBJECTIVE: We determined whether U-shaped relationships exist between serum lipoprotein[Lp](a) and cardiometabolic risk. METHODS: In population-based nondiabetic and diabetic middle-aged adults (n=1 428 and 241, respectively) who had been genotyped for the LPA rs10455872 A>G polymorphism, we adjusted the Lp(a) concentration for the effects of genotype and other covariates. Via sex-specific equations we estimated expected Lp(a) concentration in each participant , and the quotient between observed to expected Lp(a) values was determined. Lp(a) and Lp(a) quotient tertiles served to identify non-linear associations with outcomes. RESULTS: Incident 81 cases of diabetes and 128 of coronary heart disease (CHD) developed at 5.1 years' follow-up. Lp(a) concentration was linearly associated with the LPA genotype, gender, total cholesterol , (inversely) fasting insulin , which together with age formed the variables to derive the equations. In logistic regression for incident diabetes , the low Lp(a) quotient tertile was a predictor (RR 1.95 [95%CI 1.10; 3.47]) alike the low Lp(a) tertile, additively to major confounders. Cox regression models comprising sex, age, LPA genotype, smoking status, systolic pressure and serum HDL-cholesterol disclosed that, compared with the mid-tertile, both low (HR 1.77) and high Lp(a) quotient tertiles significantly predicted incident CHD, especially in women . CONCLUSION: Elevated cardiometabolic risk is conferred by apparently reduced circulating Lp(a) assays supporting the notion that "low" serum Lp(a) , mediating autoimmune activation, is a major determinant of cardiometabolic risk. © Georg Thieme Verlag KG Stuttgart · New York.
Entities: Chemical
Disease
Gene
Mutation
Species
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Year: 2014
PMID： 25314652 DOI： 10.1055/s-0034-1385922
Source DB: PubMed Journal: Exp Clin Endocrinol Diabetes ISSN： 0947-7349 Impact factor: 2.949