BACKGROUND: According to the 2002 Surgical Infection Society Guidelines on Antimicrobial Therapy for Intra-abdominal Infections, antimicrobial therapy is not recommended beyond 24 hours for the treatment of postoperative acute or gangrenous appendicitis without perforation. However, clinicians commonly consider gangrenous appendicitis to pose a greater risk of post-operative infectious complications, such as surgical site infections and intra-abdominal abscesses. This study examines the relative risk of post-operative infection between patients with simple and gangrenous appendicitis. METHODS: A retrospective review of patients with either non-perforated gangrenous or simple appendicitis from 2010 to 2012 was performed at a large urban teaching hospital. RESULTS: The rate of post-operative intra-abdominal abscess formation, which was diagnosed on patient readmission to the hospital, was significantly greater in patients with non-perforated gangrenous appendicitis in comparison to those with simple non-perforated appendicitis. Also, patients with non-perforated gangrenous appendicitis received extended courses of post-operative antibiotics, despite SIS recommendations. CONCLUSIONS: The role of peri-operative antibiotics for non-perforated gangrenous appendicitis merits further study.
BACKGROUND: According to the 2002 Surgical Infection Society Guidelines on Antimicrobial Therapy for Intra-abdominal Infections, antimicrobial therapy is not recommended beyond 24 hours for the treatment of postoperative acute or gangrenous appendicitis without perforation. However, clinicians commonly consider gangrenous appendicitis to pose a greater risk of post-operative infectious complications, such as surgical site infections and intra-abdominal abscesses. This study examines the relative risk of post-operative infection between patients with simple and gangrenous appendicitis. METHODS: A retrospective review of patients with either non-perforated gangrenous or simple appendicitis from 2010 to 2012 was performed at a large urban teaching hospital. RESULTS: The rate of post-operative intra-abdominal abscess formation, which was diagnosed on patient readmission to the hospital, was significantly greater in patients with non-perforated gangrenous appendicitis in comparison to those with simple non-perforated appendicitis. Also, patients with non-perforated gangrenous appendicitis received extended courses of post-operative antibiotics, despite SIS recommendations. CONCLUSIONS: The role of peri-operative antibiotics for non-perforated gangrenous appendicitis merits further study.
Authors: Josephine Reismann; Alessandro Romualdi; Natalie Kiss; Maximiliane I Minderjahn; Jim Kallarackal; Martina Schad; Marc Reismann Journal: PLoS One Date: 2019-09-25 Impact factor: 3.240
Authors: Nikolaos G Symeonidis; Efstathios T Pavlidis; Kyriakos K Psarras; Kalliopi Stavrati; Christina Nikolaidou; Alexandra Marneri; Georgios Geropoulos; Maria Meitanidou; Emili Andreou; Theodoros E Pavlidis Journal: Surg Res Pract Date: 2022-03-31