| Literature DB >> 25314075 |
Keli Xu1, Darius J Bägli2, Sean E Egan3.
Abstract
Human bladder cancers harbor deletions and point mutations in genes coding for Notch receptors and proteins involved in Notch signaling. This leads to elevated MAPK pathway activation, as direct Notch-mediated transcription of MAPK phosphatase DUSP is lost. These bladder tumors, with impaired Notch signaling, also show basal differentiation.Entities:
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Year: 2014 PMID： 25314075 DOI： 10.1016/j.ccell.2014.09.018
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743