Literature DB >> 25314072

Whipping NF-κB to Submission via GADD45 and MKK7.

Michael Karin1.   

Abstract

NF-κB protects malignant cells from death and therefore it was considered as a cancer treatment target. However, systemic NF-κB inhibition resulted in inflammation and other undesired outcomes. In this issue of Cancer Cell, Tornatore and colleagues solve this problem by targeting the GADD45:MKK7 module mediating NF-κB-induced survival of multiple myelomas.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25314072     DOI： 10.1016/j.ccell.2014.09.012

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  7 in total

1.  GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis.

Authors:  Arslon Humayun; Albert J Fornace
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

2.  L-carnosine induces apoptosis/cell cycle arrest via suppression of NF-κB/STAT1 pathway in HCT116 colorectal cancer cells.

Authors:  Jooyeon Lee; Jeong-Ran Park; Hanbyeol Lee; Soojin Jang; Se-Min Ryu; Hyejin Kim; Donguk Kim; Aera Jang; Se-Ran Yang
Journal:  In Vitro Cell Dev Biol Anim       Date:  2018-06-04       Impact factor: 2.416

Review 3.  Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.

Authors:  Federica Begalli; Jason Bennett; Daria Capece; Daniela Verzella; Daniel D'Andrea; Laura Tornatore; Guido Franzoso
Journal:  Biomedicines       Date:  2017-08-22

4.  GADD45β Loss Ablates Innate Immunosuppression in Cancer.

Authors:  Daniela Verzella; Jason Bennett; Mariafausta Fischietti; Anil K Thotakura; Camilla Recordati; Fabio Pasqualini; Daria Capece; Davide Vecchiotti; Daniel D'Andrea; Barbara Di Francesco; Marcella De Maglie; Federica Begalli; Laura Tornatore; Salvatore Papa; Toby Lawrence; Stuart J Forbes; Antonio Sica; Edoardo Alesse; Francesca Zazzeroni; Guido Franzoso
Journal:  Cancer Res       Date:  2017-12-26       Impact factor: 12.701

5.  The Screening of Combinatorial Peptide Libraries for Targeting Key Molecules or Protein-Protein Interactions in the NF-κB Pathway.

Authors:  Laura Tornatore; Daria Capece; Annamaria Sandomenico; Daniela Verzella; Davide Vecchiotti; Francesca Zazzeroni; Menotti Ruvo; Guido Franzoso
Journal:  Methods Mol Biol       Date:  2021

6.  TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-κB Signaling.

Authors:  Hidetaka Kawabata; Kotaro Azuma; Kazuhiro Ikeda; Ikuko Sugitani; Keiichi Kinowaki; Takeshi Fujii; Akihiko Osaki; Toshiaki Saeki; Kuniko Horie-Inoue; Satoshi Inoue
Journal:  Int J Mol Sci       Date:  2017-09-08       Impact factor: 5.923

Review 7.  NF-κB in the crosshairs: Rethinking an old riddle.

Authors:  Jason Bennett; Daria Capece; Federica Begalli; Daniela Verzella; Daniel D'Andrea; Laura Tornatore; Guido Franzoso
Journal:  Int J Biochem Cell Biol       Date:  2017-12-23       Impact factor: 5.085
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.