Literature DB >> 25313935

Multicomponent cascade cycloaddition involving tropone, allenoate, and isocyanide: a rapid access to a 7,6,5-fused tricyclic skeleton.

Shuanglong Jia1, Shikuan Su, Chunju Li, Xueshun Jia, Jian Li.   

Abstract

Multicomponent cascade cycloaddition of tropone, allenoate, and isocyanide has been disclosed. This method allows for the rapid construction of a highly unusual tricyclic skeleton in an efficient manner. The proposed transformation proceeds through [8 + 2 + 1] cycloaddition, [1,5]-H shift, and cyclization followed by an alkoxy group migration process.

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Year:  2014        PMID： 25313935     DOI： 10.1021/ol502656g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Unexpected isocyanide-based three-component bicyclization for the stereoselective synthesis of densely functionalized pyrano[3,4-c]pyrroles.

Authors:  Qian Gao; Wen-Juan Hao; Feng Liu; Shu-Jiang Tu; Shu-Liang Wang; Guigen Li; Bo Jiang
Journal:  Chem Commun (Camb)       Date:  2016-01-18       Impact factor: 6.222

2.  New Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines.

Authors:  Wen-Juan Hao; Peng Zhou; Fei-Yue Wu; Bo Jiang; Shu-Jiang Tu; Guigen Li
Journal:  European J Org Chem       Date:  2016-03-29

3.  Bran-New Four-Molecule and Five-Molecule Cascade Reactions for One-Pot Synthesis of Pyrano[3,2-c]chromen-5-ones and Spiro[benzo[b][1,4]diazepine-2,2'-pyrano[3,2-c]chromen]-5'-ones under Catalyst- and Solvent-Free Conditions.

Authors:  Guoxun Zhu; Zhou Yi; Jie Zhou; Zhiyong Chen; Pengran Guo; Yanying Huang; Jianghan Chen; Huacan Song; Wei Yi
Journal:  ACS Omega       Date:  2018-10-18
  3 in total

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