INTRODUCTION: Urachal carcinoma is a rare malignancy of urogenital tract. The objective of this study was to assess the clinical presentation, histopathological findings, treatment and outcome of patients of urachal carcinoma at a tertiary care centre. MATERIALS AND METHODS: A retrospective analysis of six cases of urachal carcinoma diagnosed over a period of 7 years from 2005 to 2011 was carried out. All pathologic specimens were reviewed by a single pathologist. Clinical and histological features along with treatment were reviewed and patient follow-up and survival outcome was obtained. RESULTS: The mean age at diagnosis was 36 years. Of the six patients, five were male. The tumor was located in dome in five and dome and anterior wall in one patient. All patients underwent partial cystectomy with bilateral pelvic lymph node dissection. The Sheldon pathologic stage was stage II in 1, IIIA in 2, IVA in 3 cases. Five out of six patients received adjuvant radiotherapy. The mean follow-up period was 37 months. Three out of six were disease free at last follow-up. CONCLUSIONS: Urachal carcinomas are rare and usually locally advanced at presentation with a high risk of distant metastases. Surgery is the primary treatment of choice. Adjuvant therapy may decrease the chances of recurrence but it needs to be elucidated by prospective trials.
INTRODUCTION:Urachal carcinoma is a rare malignancy of urogenital tract. The objective of this study was to assess the clinical presentation, histopathological findings, treatment and outcome of patients of urachal carcinoma at a tertiary care centre. MATERIALS AND METHODS: A retrospective analysis of six cases of urachal carcinoma diagnosed over a period of 7 years from 2005 to 2011 was carried out. All pathologic specimens were reviewed by a single pathologist. Clinical and histological features along with treatment were reviewed and patient follow-up and survival outcome was obtained. RESULTS: The mean age at diagnosis was 36 years. Of the six patients, five were male. The tumor was located in dome in five and dome and anterior wall in one patient. All patients underwent partial cystectomy with bilateral pelvic lymph node dissection. The Sheldon pathologic stage was stage II in 1, IIIA in 2, IVA in 3 cases. Five out of six patients received adjuvant radiotherapy. The mean follow-up period was 37 months. Three out of six were disease free at last follow-up. CONCLUSIONS:Urachal carcinomas are rare and usually locally advanced at presentation with a high risk of distant metastases. Surgery is the primary treatment of choice. Adjuvant therapy may decrease the chances of recurrence but it needs to be elucidated by prospective trials.
Authors: Davide Loizzo; Savio D Pandolfo; Fabio Crocerossa; Georgi Guruli; Matteo Ferro; Asit K Paul; Ciro Imbimbo; Giuseppe Lucarelli; Pasquale Ditonno; Riccardo Autorino Journal: Eur Urol Open Sci Date: 2022-03-14
Authors: Henning Reis; Ulrich Krafft; Christian Niedworok; Orsolya Módos; Thomas Herold; Mark Behrendt; Hikmat Al-Ahmadie; Boris Hadaschik; Peter Nyirady; Tibor Szarvas Journal: Dis Markers Date: 2018-03-12 Impact factor: 3.434
Authors: Nikolett Nagy; Henning Reis; Boris Hadaschik; Christian Niedworok; Orsolya Módos; Attila Szendrői; Krisztina Bíró; Thomas Hager; Thomas Herold; Jason Ablat; Peter C Black; Krzysztof Okon; Yuri Tolkach; Anita Csizmarik; Csilla Oláh; David Keresztes; Felix Bremmer; Nadine T Gaisa; Joerg Kriegsmann; Ilona Kovalszky; András Kiss; József Tímár; Marcell A Szász; Michael Rink; Margit Fisch; Péter Nyirády; Tibor Szarvas Journal: Pathol Oncol Res Date: 2020-08-04 Impact factor: 3.201