AIMS: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE. MATERIALS & METHODS: Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations. RESULTS: Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation. CONCLUSION: Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.
AIMS: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE. MATERIALS & METHODS: Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations. RESULTS: Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation. CONCLUSION: Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.
Authors: Stefan Hägele; Christian Nusshag; Alexander Müller; Alexandra Baumann; Martin Zeier; Ellen Krautkrämer Journal: Virol J Date: 2021-08-17 Impact factor: 4.099
Authors: Ellen Krautkrämer; Christian Nusshag; Alexandra Baumann; Julia Schäfer; Jörg Hofmann; Paul Schnitzler; Boris Klempa; Peter T Witkowski; Detlev H Krüger; Martin Zeier Journal: BMC Infect Dis Date: 2016-11-14 Impact factor: 3.090
Authors: J Klingström; A Smed-Sörensen; K T Maleki; C Solà-Riera; C Ahlm; N K Björkström; H G Ljunggren Journal: J Intern Med Date: 2019-02-17 Impact factor: 8.989