Literature DB >> 25313210

In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites.

Christian S Lentz1, Julia M Sattler2, Martina Fendler1, Simon Gottwalt2, Victoria S Halls3, Silke Strassel1, Sandra Arriens1, Jeffrey S Hannam3, Sabine Specht1, Michael Famulok3, Ann-Kristin Mueller2, Achim Hoerauf1, Kenneth M Pfarr4.   

Abstract

wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). One of these derivatives inhibited gliding motility of Plasmodium berghei ANKA infectious sporozoites with nanomolar affinity and blocked invasion into hepatocytes but did not affect intrahepatocytic replication. Hence, wALADin1 benzimidazoles are tools to study gliding motility and potential antiplasmodial drug candidates.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25313210      PMCID： PMC4291411          DOI： 10.1128/AAC.02383-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

Review 1.  Apicomplexan gliding motility and host cell invasion: overhauling the motor model.

Authors:  Stefan H I Kappe; Carlos A Buscaglia; Lawrence W Bergman; Isabelle Coppens; Victor Nussenzweig
Journal:  Trends Parasitol       Date:  2004-01

2.  de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite.

Authors:  N Surolia; G Padmanaban
Journal:  Biochem Biophys Res Commun       Date:  1992-09-16       Impact factor: 3.575

3.  Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites.

Authors:  Sylvia Münter; Benedikt Sabass; Christine Selhuber-Unkel; Mikhail Kudryashev; Stephan Hegge; Ulrike Engel; Joachim P Spatz; Kai Matuschewski; Ulrich S Schwarz; Friedrich Frischknecht
Journal:  Cell Host Microbe       Date:  2009-12-17       Impact factor: 21.023

4.  Malaria sporozoite penetration. A new approach by double staining.

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Journal:  J Immunol Methods       Date:  1988-09-13       Impact factor: 2.303

5.  The genome of Plasmodium falciparum encodes an active delta-aminolevulinic acid dehydratase.

Authors:  Shigeharu Sato; R J M Wilson
Journal:  Curr Genet       Date:  2002-02-06       Impact factor: 3.886

6.  Heme biosynthesis by the malarial parasite. Import of delta-aminolevulinate dehydrase from the host red cell.

Authors:  Z Q Bonday; S Taketani; P D Gupta; G Padmanaban
Journal:  J Biol Chem       Date:  1997-08-29       Impact factor: 5.157

7.  Malaria sporozoites release circumsporozoite protein from their apical end and translocate it along their surface.

Authors:  M J Stewart; J P Vanderberg
Journal:  J Protozool       Date:  1991 Jul-Aug

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Authors:  M Tsuji; D Mattei; R S Nussenzweig; D Eichinger; F Zavala
Journal:  Parasitol Res       Date:  1994       Impact factor: 2.289

9.  Delta-aminolevulinic acid dehydratase from Plasmodium falciparum: indigenous versus imported.

Authors:  Shanmugham Dhanasekaran; Nagasuma R Chandra; B K Chandrasekhar Sagar; Pundi N Rangarajan; Govindarajan Padmanaban
Journal:  J Biol Chem       Date:  2003-11-24       Impact factor: 5.157

10.  Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection.

Authors:  P Potocnjak; N Yoshida; R S Nussenzweig; V Nussenzweig
Journal:  J Exp Med       Date:  1980-06-01       Impact factor: 14.307
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  1 in total

Review 1.  Phthalimide analogs for antimalarial drug discovery.

Authors:  Meenakshi Bansal; Charu Upadhyay; Sumit Kumar; Brijesh Rathi
Journal:  RSC Med Chem       Date:  2021-08-13
  1 in total

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